Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study

J.T. Lear; M.R. Migden; K.D. Lewis; A.L.S. Chang; A. Guminski; R. Gutzmer; L. Dirix; P. Combemale; A. Stratigos; R. Plummer; H. Castro; T. Yi; M. Mone; J. Zhou; U. Trefzer; M. Kaatz; C. Loquai; R. Kudchadkar; D. Sellami; R. Dummer

doi:10.1111/jdv.14542

Long-term efficacy and safety of sonidegib in patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/jdv.14542 ◽

2017 ◽

Vol 32 (3) ◽

pp. 372-381 ◽

Cited By ~ 54

Author(s):

J.T. Lear ◽

M.R. Migden ◽

K.D. Lewis ◽

A.L.S. Chang ◽

A. Guminski ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Locally Advanced ◽

Phase 2 ◽

Efficacy And Safety ◽

Term Efficacy ◽

Metastatic Basal Cell Carcinoma ◽

Randomized Phase 2

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A 12-month update of BOLT, a phase 2, randomized, double-blind study of sonidegib (LDE225) in patients with locally advanced or metastatic basal cell carcinoma

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2015.02.729 ◽

2015 ◽

Vol 72 (5) ◽

pp. AB178

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Locally Advanced ◽

Blind Study ◽

Double Blind Study ◽

Phase 2 ◽

Double Blind ◽

Metastatic Basal Cell Carcinoma

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Efficacy and safety of sonidegib in patients with aggressive and nonaggressive subtypes of locally advanced basal cell carcinoma: Long-term 42-month results from the BOLT study

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2019.06.736 ◽

2019 ◽

Vol 81 (4) ◽

pp. AB199

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Locally Advanced ◽

Efficacy And Safety ◽

Advanced Basal Cell Carcinoma

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Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial

The Lancet Oncology ◽

10.1016/s1470-2045(15)70100-2 ◽

2015 ◽

Vol 16 (6) ◽

pp. 716-728 ◽

Cited By ~ 175

Author(s):

Michael R Migden ◽

Alexander Guminski ◽

Ralf Gutzmer ◽

Luc Dirix ◽

Karl D Lewis ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Locally Advanced ◽

Phase 2 ◽

Double Blind ◽

Phase 2 Trial ◽

Metastatic Basal Cell Carcinoma ◽

Different Doses

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Faculty Opinions recommendation of Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725503664.793539334 ◽

2017 ◽

Author(s):

David Leffell

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Locally Advanced ◽

Phase 2 ◽

Double Blind ◽

Phase 2 Trial ◽

Metastatic Basal Cell Carcinoma ◽

Different Doses

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Long‐term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42‐month analysis of the phase II randomized, double‐blind BOLT study

British Journal of Dermatology ◽

10.1111/bjd.18552 ◽

2019 ◽

Vol 182 (6) ◽

pp. 1369-1378 ◽

Cited By ~ 12

Author(s):

R. Dummer ◽

A. Guminksi ◽

R. Gutzmer ◽

J.T. Lear ◽

K.D. Lewis ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Phase Ii ◽

Basal Cell ◽

Efficacy And Safety ◽

Double Blind ◽

Term Efficacy ◽

Advanced Basal Cell Carcinoma

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Efficacy of sonidegib in histologic subtypes of advanced basal cell carcinoma: Results from the final analysis of the randomized phase 2 Basal Cell Carcinoma Outcomes With LDE225 Treatment (BOLT) trial at 42 months

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2020.08.042 ◽

2020 ◽

Author(s):

Reinhard Dummer ◽

John T. Lear ◽

Alex Guminski ◽

Liang Joo Leow ◽

Nicholas Squittieri ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Final Analysis ◽

Phase 2 ◽

Histologic Subtypes ◽

Randomized Phase 2 ◽

Advanced Basal Cell Carcinoma

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Efficacy and tolerability of vismodegib treatment in locally advanced and metastatic basal cell carcinoma: retrospective real‐life data

Dermatologic Therapy ◽

10.1111/dth.15122 ◽

2021 ◽

Author(s):

Mustafa Gürbüz ◽

İzzet DoĞan ◽

Erman AkkuŞ ◽

Hande ErmiŞ ◽

Güngör Utkan ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Locally Advanced ◽

Real Life ◽

Life Data ◽

Real Life Data ◽

Metastatic Basal Cell Carcinoma

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26200 Tumor burden in patients with locally advanced basal cell carcinoma and metastatic basal cell carcinoma following treatment with sonidegib: Results of the 42-month BOLT study

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2021.06.377 ◽

2021 ◽

Vol 85 (3) ◽

pp. AB89

Author(s):

Michael Migden ◽

Aaron S. Farberg ◽

James Spencer ◽

Felix Kiecker ◽

Alexander Guminski ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Locally Advanced ◽

Tumor Burden ◽

Metastatic Basal Cell Carcinoma ◽

Advanced Basal Cell Carcinoma

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Abstract LB-138: Efficacy data of GDC-0449, a systemic Hedgehog pathway antagonist, in a first-in-human, first-in-class Phase I study with locally advanced, multifocal or metastatic basal cell carcinoma patients

10.1158/1538-7445.am2008-lb-138 ◽

2008 ◽

Cited By ~ 5

Author(s):

Daniel D Von Hoff ◽

Charles M Rudin ◽

Patricia M LoRusso ◽

Mitesh J Borad ◽

Ronald L Korn ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Phase I ◽

Cell Carcinoma ◽

Basal Cell ◽

Phase I Study ◽

Locally Advanced ◽

Hedgehog Pathway ◽

Efficacy Data ◽

Metastatic Basal Cell Carcinoma

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Efficacy and Safety of Sonidegib in Adult Patients with Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome): Results from a Phase 2, Double-Blind, Randomized Trial

Clinical Cosmetic and Investigational Dermatology ◽

10.2147/ccid.s233097 ◽

2020 ◽

Vol Volume 13 ◽

pp. 117-121 ◽

Cited By ~ 3

Author(s):

John T Lear ◽

Axel Hauschild ◽

Eggert Stockfleth ◽

Nicholas Squittieri ◽

Nicole Basset-Seguin ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Randomized Trial ◽

Cell Carcinoma ◽

Basal Cell ◽

Adult Patients ◽

Phase 2 ◽

Efficacy And Safety ◽

Gorlin Syndrome ◽

Double Blind

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