Degranulation and shrinkage of dark cells in eccrine glands and elevated serum carcinoembryonic antigen in patients with acquired idiopathic generalized anhidrosis

2017 ◽  
Vol 31 (12) ◽  
pp. 2097-2103 ◽  
Author(s):  
K. Sano ◽  
M. Asahina ◽  
T. Uehara ◽  
K. Matsumoto ◽  
N. Araki ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Elevated Serum ◽  
Dark Cells ◽  
Eccrine Glands ◽  
Serum Carcinoembryonic Antigen

Secretory meningioma with elevated serum carcinoembryonic antigen level

1992 ◽  
Vol 37 (5) ◽  
pp. 415-418 ◽  
Author(s):  
Shigeru Tsunoda ◽  
Toshikazu Takeshima ◽  
Toshisuke Sakaki ◽  
Tetsuya Morimoto ◽  
Toru Hoshida ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Elevated Serum ◽  
Antigen Level ◽  
Secretory Meningioma ◽  
Serum Carcinoembryonic Antigen

scholarly journals Serum carcinoembryonic antigen as a tumour marker in patients with endometrial cancer

2016 ◽  
Vol 23 (5) ◽  
pp. 439 ◽  
Author(s):  
Y. Hashiguchi ◽  
M. Kasai ◽  
T. Fukuda ◽  
T. Ichimura ◽  
T. Yasui ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Carcinoembryonic Antigen ◽  
Menopausal Status ◽  
Elevated Serum ◽  
Case Series ◽  
Myometrial Invasion ◽  
Tumour Markers ◽  
Serum Carcinoembryonic Antigen ◽  
Serum Cea

Background No potential tumour markers have been validated for prognosis in endometrial cancer. However, carcinoembryonic antigen (cea) is one of the most widely used tumour markers in various types of cancer. Although cea expression in endometrial cancer has been investigated, its prognostic value remains controversial, and no studies have investigated serum cea levels in large case series. In the present study, we investigated diagnostic and prognostic applications of serum cea for endometrial cancer.Methods This prospective study was approved by our Institutional Review Board. Between January 2006 and December 2012, serum cea was measured prospectively in 215 patients with endometrial cancer and was subsequently measured during treatment and at scheduled follow-up examinations in patients with elevated basely ne serum cea.Results During the study period, 215 patients (142 stage i, 19 stage ii, 32 stage iii, 22 stage iv) were treated for endometrial cancer. By the time of last follow-up, 52 had relapsed (24.2%), and the median follow-up duration was 45 months (range: 1–95 months). Elevated serum cea was identified in 25 patients (11.6%) and was associated with histologic type (p = 0.04), histologic grade (p = 0.03), and myometrial invasion depth (p = 0.01). Elevated serum cea was not related to clinical stage, lymph node metastasis, distant metastasis, age, menopausal status, or body mass index. Relapse of disease was related to elevated serum cea (p = 0.006).Conclusions Serum cea is a potential prognostic indicator for endometrial cancer.

Pseudopsammomatous meningioma with elevated serum carcinoembryonic antigen: a true secretory meningioma

1991 ◽  
Vol 74 (1) ◽  
pp. 129-132 ◽  
Author(s):  
David N. Louis ◽  
Allan J. Hamilton ◽  
Raymond A. Sobel ◽  
Robert G. Ojemann
Keyword(s):  
Carcinoembryonic Antigen ◽  
Elevated Serum ◽  
Immunohistochemical Analysis ◽  
Intracranial Tumor ◽  
Vascular Pattern ◽  
Rare Occurrence ◽  
Content Type ◽  
Secretory Meningioma ◽  
Serum Carcinoembryonic Antigen ◽  
Serum Cea

✓ A sphenoid-wing meningioma in a 60-year-old woman was accompanied by elevated serum carcinoembryonic antigen (CEA) levels, which returned to normal after removal of the tumor. Light microscopic examination revealed a secretory meningioma containing numerous pseudopsammoma bodies and a prominent vascular pattern. Immunohistochemical analysis showed the tumor cells and pseudopsammoma bodies to be CEA-positive. This case illustrates the possibility that secretory meningioma may be associated with clinically detectable secretion of CEA. The report also documents the rare occurrence of elevated serum CEA in a primary benign intracranial tumor.

scholarly journals A CASE REPORT OF PRIMARY APPENDICEAL CARCINOMA WITH ELEVATED SERUM CARCINOEMBRYONIC ANTIGEN

1998 ◽  
Vol 59 (5) ◽  
pp. 1317-1322 ◽  
Author(s):  
Shingo NOURA ◽  
Junkou FURUKAWA ◽  
Kazunori NAKAGUCHI ◽  
Shirou OKAJIMA ◽  
Fumiaki SUE ◽  
...  
Keyword(s):  
Case Report ◽  
Carcinoembryonic Antigen ◽  
Elevated Serum ◽  
Serum Carcinoembryonic Antigen ◽  
Appendiceal Carcinoma

Elevated carcinoembryonic antigen predicts rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis

Rheumatology ◽  
2021 ◽  
Author(s):  
Dingxian Zhu ◽  
Jianjun Qiao ◽  
Shunli Tang ◽  
Yunlei Pan ◽  
Sheng Li ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Carcinoembryonic Antigen ◽  
Elevated Serum ◽  
Multivariate Logistic Regression Analysis ◽  
Laboratory Findings ◽  
Serum Carcinoembryonic Antigen ◽  
Lower Lung ◽  
Serum Cea ◽  
Lung Zone

Abstract Objectives The present study aimed to determine the correlation between serum carcinoembryonic antigen (CEA) level and the severity of interstitial lung disease (ILD) in clinically amyopathic DM (CADM) patients. Methods We performed a retrospective study including 41 Chinese CADM patients without malignancy. Serum CEA levels, clinical and laboratory findings were collected. Association tests between CEA levels and disease activity parameters were performed. Results Among the 41 patients, 16 (39.0%) developed rapidly progressive (RP)-ILD; of them, 14 (87.5%) had elevated serum CEA levels. Multivariate logistic regression analysis indicated that an elevated serum CEA level was an independent risk factor for RP-ILD. The incidence of elevated CEA level was significantly higher in patients with RP-ILD than in those without RP-ILD (87.5 vs 16.0%, P < 0.001). Furthermore, CEA levels were higher in patients with CADM with RP-ILD [26.87 (6.71) μg/l] than in those without RP-ILD [3.23 (0.64) μg/l] (P < 0.001). CEA levels in CADM patients were associated with the ferritin, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase levels, and CT scores of the lungs. Also, elevated CEA levels are related to the organizing pneumonia pattern and lower lung zone consolidation in high-resolution CT. Moreover, the cumulative survival rate was significantly lower (68.4 vs 31.6%, P < 0.001) in the group with a CEA level >8.75 μg/l than that in the group with a CEA level <8.75 μg/l. Conclusions An elevated serum CEA level is common in patients with CADM, and a higher serum CEA level is a powerful indicator of RP-ILD and poor prognosis in those patients.

Carbohydrate Antigen 19-9 and Carcinoembryonic Antigen Immunostaining in Benign Multicystic Mesothelioma of the Peritoneum

2001 ◽  
Vol 125 (7) ◽  
pp. 944-947
Author(s):  
Robert N. N. Holtzman ◽  
A. Douglas Heymann ◽  
Fausto Bordone ◽  
Gianfilippo Marinoni ◽  
Paolo Barillari ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Elevated Serum ◽  
Liver Cyst ◽  
Carbohydrate Antigen ◽  
Ca 125 ◽  
Imaging Studies ◽  
Cancer Antigen 125 ◽  
Mesothelial Cyst ◽  
Serum Carcinoembryonic Antigen ◽  
Benign Multicystic Mesothelioma

Abstract A 58-year-old Italian man was incidentally discovered to have an elevated carbohydrate antigen 19-9 (CA-19-9) level of 132 U/mL on routine blood testing. Multisystem imaging studies revealed multiple benign-appearing cysts of the liver and single cysts in the pancreas and kidney parenchyma. Throughout 14 months, fluctuations were observed in the elevated serum CA-19-9 levels from 99 to 450 U/mL. Serum carcinoembryonic antigen (CEA) and other tumor markers were normal. Laparoscopy disclosed multiple cystic lesions on the surface of the liver, on the serosal surface of the ileum, and in the mesentery. Electron microscopy characterized the cells as mesothelial. The pathologic diagnosis was benign multicystic mesothelioma of the peritoneum (BMMP). Aspirated fluid from the liver cyst revealed CA-19-9 levels at 28 500 U/mL, strongly linking the elevated serum CA-19-9 levels with mesothelial cyst secretion. Immunostaining was positive for CA-19-9, CEA, and cancer antigen 125 (CA-125). We believe this is the first documented instance of CA-19-9 and CEA secretion in BMMP.

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