Spiny hyperkeratosis (trichodysplasia spinulosa-like eruption): a cutaneous adverse effect of Hedgehog pathway inhibitors involving expression of p16

2016 ◽  
Vol 31 (4) ◽  
pp. e182-e184 ◽  
Author(s):  
I. López-Lerma ◽  
B. Ferrer ◽  
I. Zarzoso ◽  
J. Hernández-Losa ◽  
V. García-Patos
Author(s):  
Nandakishore Thokchom ◽  
Nandita Bhattacharjee ◽  
Linda Kongbam

<p class="abstract">Bleomycin is an antitumour antibiotic commonly used in the management of Hodgkin’s lymphoma and germ cell tumours. Flagellate pigmentation is a very specific and rare cutaneous adverse effect of bleomycin. It is characterised by linear, painless, pruritic, hyperpigmented lesions simulating marks of whiplashes over trunk and extremities. With the advent of targeted therapies resulting in the infrequent use of bleomycin, this unique side effect is also uncommonly encountered nowadays. Here, we report a case of bleomycin-induced flagellate pigmentation in a 35-year-old Indian female with ovarian teratoma. The characteristic patterned hyperpigmented patches developed following 2nd cycle of chemotherapy with bleomycin, etoposide and cisplatin.</p><p class="abstract"> </p>


Author(s):  
Fatma P. Cengiz ◽  
Ozlem Su ◽  
Nazan Emiroglu ◽  
Dilek Biyik Ozkaya ◽  
Anil G. Bahali ◽  
...  

2015 ◽  
Vol 145 (8) ◽  
pp. 372-373
Author(s):  
María Castellanos-González ◽  
Javier Ballesteros Bargues

2018 ◽  
Vol 6 ◽  
pp. 2050313X1880926 ◽  
Author(s):  
Maria Monica Haydock ◽  
Saroj Sigdel ◽  
Toni Pacioles

Since its emergence as a chemotherapy agent, gemcitabine has been associated with cutaneous adverse reactions. Rash is reported to be the most common cutaneous adverse effect. Other reported cutaneous reactions in the literature include bullous dermatosis, pseudocellulitis, subacute cutaneous lupus alopecia, and palmar–plantar erythrodysesthesia. Skin necrosis is a very rare adverse effect of this otherwise well-tolerated chemotherapeutic agent. In searching the literature, only one other case has been reported. In our report, we present a 74-year-old male with adenocarcinoma of the pancreas, status-post pancreaticoduodenectomy (Whipple procedure), who developed a rare case of skin necrosis of the lower leg 2 weeks after completing six cycles of monotherapy gemcitabine treatment.


Author(s):  
Pooja Arora ◽  
Kabir Sardana ◽  
Sinu Rose Mathachan ◽  
Purnima Malhotra

2014 ◽  
Vol 371 (13) ◽  
pp. 1265-1267 ◽  
Author(s):  
Stephen John Sammut ◽  
Nevianna Tomson ◽  
Pippa Corrie

2018 ◽  
Vol 2018 (12) ◽  
Author(s):  
Siona Growcott ◽  
Alexandra Banner ◽  
Adam Bray ◽  
Serena Hilman

2011 ◽  
Vol 56 (6) ◽  
pp. 752 ◽  
Author(s):  
SibaP Raychaudhuri ◽  
Mondhipa Ratnarathorn ◽  
Stanley Naguwa

2010 ◽  
Vol 28 (31) ◽  
pp. e640-e642 ◽  
Author(s):  
Nathalie Franck ◽  
Stéphane Barete ◽  
Philippe Moguelet ◽  
Benoît Blanchet ◽  
Agnès Carlotti ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document