Comparative histological analysis of drug-induced maculopapular exanthema and DRESS

2016 ◽  
Vol 30 (12) ◽  
pp. 2085-2090 ◽  
Author(s):  
F. Skowron ◽  
B. Bensaid ◽  
B. Balme ◽  
L. Depaepe ◽  
J. Kanitakis ◽  
...  
Keyword(s):  
Histological Analysis ◽  
Drug Induced ◽  
Maculopapular Exanthema

Expression of the Tim3‐galectin‐9 axis is altered in drug‐induced maculopapular exanthema

Allergy ◽  
2019 ◽  
Vol 74 (9) ◽  
pp. 1769-1779 ◽  
Author(s):  
Ruben Fernandez‐Santamaría ◽  
Francisca Palomares ◽  
Maria Salas ◽  
Inmaculada Doña ◽  
Gador Bogas ◽  
...  
Keyword(s):  
Drug Induced ◽  
Maculopapular Exanthema

Up-regulation of CCL17, CCL22 and CCR4 in drug-induced maculopapular exanthema

2007 ◽  
Vol 37 (5) ◽  
pp. 704-713 ◽  
Author(s):  
B. Tapia ◽  
E. Morel ◽  
M.-Á. Martín-Díaz ◽  
R. Díaz ◽  
J. Alves-Ferreira ◽  
...  
Keyword(s):  
Drug Induced ◽  
Maculopapular Exanthema

scholarly journals Dress Syndrome - A Case Report

2016 ◽  
Vol 8 (2) ◽  
pp. 95-100 ◽  
Author(s):  
Zorana Kremić ◽  
Željko P. Mijušković ◽  
Lidija Kandolf-Sekulović
Keyword(s):  
Supportive Therapy ◽  
Dress Syndrome ◽  
Drug Induced ◽  
Systemic Manifestations ◽  
Inflammatory Drugs ◽  
Hematological Abnormalities ◽  
Systemic Symptoms ◽  
Generalized Epilepsy ◽  
Maculopapular Exanthema ◽  
Induced Reaction

Abstract The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an adverse drug-induced reaction that occurs most commonly after exposure to drugs, most frequently anticonvulsants, sulfa derivates, antidepressants, nonsteroidal anti-inflammatory drugs, and antimicrobials. We present a 61-year-old male, with a generalized maculopapular exanthema on the trunk, face, extremities, palms, soles, palate, and fever (38°C). His medical history was notable for generalized epilepsy, treated with carbamazepine during 1 month. The diagnosis of DRESS syndrome was confirmed by specific RegiSCAR criteria. In our case, skin eruptions were successfully treated with oral methylprednisolone, cephalexin, and topical corticosteroid ointment. In conclusion, although the mechanisms of this syndrome are not completely understood, numerous cases were reported in children and adults. This syndrome should be considered in every patient with skin eruption, fever, eosinophilia, liver and hematological abnormalities. Prompt recognition, supportive therapy and initiation of corticosteroids may prevent systemic manifestations.

scholarly journals Proliferation control of specific-effector T cells and T-Regulatory cells by Tim-3 and Galectin-9 in Drug-Induced Maculopapular Exanthema

2019 ◽  
Vol 143 (2) ◽  
pp. AB65
Author(s):  
Tahia D. Fernandez ◽  
Maria Francisca Palomares ◽  
Ruben Fernandez-Santamaria ◽  
Alba Rodriguez-Nogales ◽  
Maria Jose Rodriguez ◽  
...  
Keyword(s):  
T Cells ◽  
T Regulatory Cells ◽  
Effector T Cells ◽  
Regulatory Cells ◽  
Drug Induced ◽  
Proliferation Control ◽  
Specific Effector ◽  
Maculopapular Exanthema

scholarly journals HLA Risk Alleles in Aromatic Antiepileptic Drug-Induced Maculopapular Exanthema

2021 ◽  
Vol 12 ◽  
Author(s):  
Yi-Wu Shi ◽  
Jie Wang ◽  
Fu-Li Min ◽  
Wen-Jun Bian ◽  
Bi-Jun Mao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Antiepileptic Drug ◽  
In Silico ◽  
Risk Allele ◽  
Meta Analysis ◽  
Protein Drug ◽  
Drug Induced ◽  
Risk Alleles ◽  
Different Populations ◽  
Maculopapular Exanthema

To characterize human leukocyte antigen (HLA) loci as risk factors in aromatic antiepileptic drug-induced maculopapular exanthema (AED-MPE). A case-control study was performed to investigate HLA loci involved in AED-MPE in a southern Han Chinese population. Between January 2007 and June 2019, 267 patients with carbamazepine (CBZ), oxcarbazepine (OXC), or lamotrigine (LTG) associated MPE and 387 matched drug-tolerant controls from six centers were enrolled. HLA-A/B/C/DRB1 genotypes were determined using sequence-based typing. Potential risk alleles were validated by meta-analysis using data from different populations and in silico analysis of protein-drug interactions. HLA-DRB1*04:06 was significantly associated with OXC-MPE (p = 0.002, pc = 0.04). HLA-B*38:02 was associated with CBZ-MPE (p = 0.03). When pooled, HLA-A*24:02, HLA-A*30:01, and HLA-B*35:01 additionally revealed significant association with AED-MPE. Logistic regression analysis showed a multiplicative interaction between HLA-A*24:02 and HLA-B*38:02 in CBZ-MPE. Meta-analysis of data from different populations revealed that HLA-24*:02 and HLA-A*30:01 were associated with AED-MPE (p = 0.02 and p = 0.04, respectively). In silico analysis of protein-drug interaction demonstrated that HLA-A*24:02 and HLA-A*30:01 had higher affinities with the three aromatic AEDs than the risk-free HLA-A allele. HLA-DRB1*04:06 showed relatively specific high affinity with S-monohydroxy derivative of OXC. HLA-DRB1*04:06 is a specific risk allele for OXC-induced MPE in the Southern Han Chinese. HLA-A*24:02, possibly HLA-A*30:01, are common risk factors for AED-MPE. The multiplicative risk potential between HLA-A*24:02 and HLA-B*38:02 suggests that patients with two risk alleles are at greater risk than those with one risk allele. Inclusion of these HLA alleles in pre-treatment screening would help estimating the risk of AED-MPE.

Role of Effector Cells In Drug-induced Maculopapular Exanthema

2008 ◽  
Vol 121 (2) ◽  
pp. S68-S68
Author(s):  
T FERNANDEZ ◽  
M TORRES ◽  
C ANTUNEZ ◽  
J CORNEJOGARCIA ◽  
M DELPRADO ◽  
...  
Keyword(s):  
Drug Induced ◽  
Effector Cells ◽  
Maculopapular Exanthema
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