scholarly journals The impact of biologic therapy in chronic plaque psoriasis from a societal perspective: an analysis based on Italian actual clinical practice

2015 ◽  
Vol 29 (12) ◽  
pp. 2411-2416 ◽  
Author(s):  
B. Polistena ◽  
P. Calzavara-Pinton ◽  
G. Altomare ◽  
E. Berardesca ◽  
G. Girolomoni ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Societal Perspective ◽  
Plaque Psoriasis ◽  
Biologic Therapy ◽  
Chronic Plaque Psoriasis ◽  
Actual Clinical Practice ◽  
The Impact

scholarly journals The impact of the Oncotype Dx breast cancer assay in clinical practice: Systematic review and meta-analysis.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 560-560
Author(s):  
Josh John Carlson ◽  
Joshua A. Roth
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Clinical Practice ◽  
Early Stage ◽  
Meta Analysis ◽  
Oncotype Dx ◽  
Limited Sample ◽  
Actual Clinical Practice ◽  
Practice Methods ◽  
The Impact

560 Background: Many studies have evaluated the Oncotype Dx Breast Cancer Assay (ODX) and its impact on adjuvant chemotherapy (ACT) treatment decisions. However, it can be difficult for clinicians and other stakeholders to interpret the collective findings of these studies, as they were conducted in diverse settings and have limited sample sizes. To address this issue, we conducted a systematic review and meta-analysis to synthesize ODX results and provide insights about the utility of ODX in actual clinical practice. Methods: We performed a systematic review of ODX studies using PubMed, Embase, ASCO, and SABCS. Studies were included if patients had ER +, node -, early stage breast cancer, reported use of ODX to inform actual ACT decisions, and reported outcomes of interest, including: 1) distribution of ODX recurrence scores (RS); 2) impact of ODX on ACT recommendations; 3) impact of ODX on ACT use; and 4) proportion of patients following the treatment suggested by the ODX RS. Results: A total of 28 studies met inclusion criteria. The distribution of RS categories was 48.8% low, 39.0% intermediate, and 12.2% high (21 studies, 4,156 patients). ODX changed the clinical-pathological ACT recommendation in 33.4% of patients (8 studies, 1,437 patients). In patients receiving ODX, receipt of ACT was: 28.2% overall, 5.8% low, 37.4% intermediate, and 83.4% high. High RS patients were significantly more likely to follow the treatment suggested by ODX vs. low RS patients RR: 1.07 (1.01–1.14). Conclusions: The pooled results for the impact of ODX on ACT recommendations are consistent with most individual studies to date. However, the proportion of intermediate RS results is nearly 2-fold higher than reported in the ODX development studies by Paik et al., which may have implications for the clinical utility and cost impacts of testing. Also, high RS vs. low RS patients were more likely to follow the ODX results, suggesting a tendency toward aggressive treatment despite a low ODX RS. Finally, there was a lack of studies on the impact of ODX on ACT use vs. standard approaches, suggesting additional studies are warranted. [Table: see text]

scholarly journals The Cost Effectiveness of Biologic Therapy for the Treatment of Chronic Plaque Psoriasis in Real Practice Settings in Italy

BioDrugs ◽  
2014 ◽  
Vol 28 (3) ◽  
pp. 285-295 ◽  
Author(s):  
Federico Spandonaro ◽  
Fabio Ayala ◽  
Enzo Berardesca ◽  
Sergio Chimenti ◽  
Giampiero Girolomoni ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Plaque Psoriasis ◽  
Biologic Therapy ◽  
Chronic Plaque Psoriasis ◽  
The Cost ◽  
Real Practice

Translating Principles of Speech Science to Clinical Practice: Current and Future Trends in Craniofacial Disorders

2008 ◽  
Vol 18 (1) ◽  
pp. 31-40 ◽  
Author(s):  
David J. Zajac
Keyword(s):  
Clinical Practice ◽  
Speech Intelligibility ◽  
Current Practice ◽  
Computer Assisted ◽  
Behavioral Management ◽  
Single Word ◽  
Future Directions ◽  
Speech Science ◽  
The Impact ◽  
Opinion Article

Abstract The purpose of this opinion article is to review the impact of the principles and technology of speech science on clinical practice in the area of craniofacial disorders. Current practice relative to (a) speech aerodynamic assessment, (b) computer-assisted single-word speech intelligibility testing, and (c) behavioral management of hypernasal resonance are reviewed. Future directions and/or refinement of each area are also identified. It is suggested that both challenging and rewarding times are in store for clinical researchers in craniofacial disorders.

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