Primary cutaneous diffuse large B-cell lymphoma with cranial vault and dura mater involvement

2014 ◽  
Vol 30 (1) ◽  
pp. 186-187 ◽  
Author(s):  
M. Mascolo ◽  
V. Piccolo ◽  
G. Iannuzzo ◽  
P. Di Lorenzo ◽  
G. De Rosa ◽  
...  
2006 ◽  
Vol 21 (5) ◽  
pp. 1-4 ◽  
Author(s):  
Marcelo Galarza ◽  
Roberto Gazzeri ◽  
Hamed A. Elfeky ◽  
Robert R. Johnson

✓ Primary high-grade lymphoma of the dura mater and cranial vault has rarely been reported. The authors treated a 61-year-old man who presented with a slow-growing scalp mass that involved the cranial vertex. Magnetic resonance imaging revealed an oval mass of the dural type with peripheral edema in the bilateral parietal region, with attachment to the cranial vault and extension to the subgaleal space. After subtotal resection, pathological examination yielded a diagnosis of malignant large B-cell lymphoma. Twenty-three months postoperatively, after undergoing radiation therapy and chemotherapy, the patient is neurologically intact and without systemic dissemination of the malignancy. This is a case of primary malignant B-cell lymphoma of the dura mater with extensive involvement of the skull, which is a very rare event. Imaging-based diagnosis and combined therapy consisting of surgery, radiation therapy, and chemotherapy for the disease are discussed, and the literature on extraaxial malignant lymphomas is extensively reviewed.


Neurology ◽  
2009 ◽  
Vol 73 (17) ◽  
pp. e84-e85 ◽  
Author(s):  
D. Renard ◽  
C. Campello ◽  
O. Beraru ◽  
P. Bouillot ◽  
P. Labauge

2015 ◽  
Vol 32 (4) ◽  
pp. 275-280 ◽  
Author(s):  
Ryosuke Tashiro ◽  
Masayuki Kanamori ◽  
Hiroyoshi Suzuki ◽  
Akihiro Utsunomiya ◽  
Kuniaki Meguro ◽  
...  

2015 ◽  
Vol 25 (3) ◽  
pp. 324-330 ◽  
Author(s):  
Sarbjit S. Chhiber ◽  
Altaf R. Kirmani ◽  
Altaf U. Ramzan ◽  
Afzal Wani ◽  
Nayil K. Malik ◽  
...  

2017 ◽  
Vol 106 (2) ◽  
pp. 147-148 ◽  
Author(s):  
Minoru Kanaya ◽  
Tomoyuki Endo ◽  
Daigo Hashimoto ◽  
Shogo Endo ◽  
Ryo Takemura ◽  
...  

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Tatsuya Uchida ◽  
Kenichi Amagasaki ◽  
Atsushi Hosono ◽  
Hiroshi Nakaguchi

Abstract Background It is extremely rare for primary non-Hodgkin’s lymphomas to occur singly in the cranial vault. One case diagnosed as primary diffuse large B-cell lymphoma is reported, initially misdiagnosed as metastatic skull tumor, complicated with Trousseau syndrome. Case description The patient was a 60-year-old Japanese woman with no particular previous medical history. In a head computed tomography examination for vertigo, bone destructive skull tumor covering the right frontal, parietal, and temporal bones was incidentally discovered. As positron emission tomography indicated an abnormal accumulation in the large intestine and multiple cerebral infarctions suspicious of Trousseau syndrome were observed on magnetic resonance images, a metastatic skull tumor due to colorectal cancer was first considered. However, various tumor markers were negative, and colonoscopic biopsy indicated no colorectal abnormality. After pathological examination of the resected tumor, it was diagnosed as diffuse large B-cell lymphoma. The tumor affected muscles and skin but did not develop in the brain or the dura mater. As further general examination revealed no other abnormalities, we considered that it was primary diffuse large B-cell lymphoma in the cranial vault associated with Trousseau syndrome. Treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone and high-dose methotrexate reduced the residual lesion; coagulation abnormalities, which are frequently associated with Trousseau syndrome, also improved. Conclusions Skull tumors can result from a variety of malignancies, and their diagnosis may be complicated with Trousseau syndrome. However, even in cases of a single lesion in the cranial vault without invasion of the central nervous system, diffuse large B-cell lymphoma should be considered as a differential diagnosis.


2019 ◽  
Vol 1 (Supplement_2) ◽  
pp. ii34-ii34
Author(s):  
Naoki Nitta ◽  
Tadateru Fukami ◽  
Akifumi Sasao ◽  
Kazuhiko Nozaki

Abstract BACKGROUND Tumors other than meningiomas, cavernous malformations and metastatic tumors rarely originate in the cranial vault. We report a case of primary diffuse large B-cell lymphoma of the cranial vault. CASE DESCRIPTION A 58-year-old woman was referred to our hospital because of a right frontal subcutaneous mass that had rapidly increased in size. The patient had been well until approximately 2 months before this referral, when she had slight difficulty in opening the right eye. Thereafter she had headaches and a swelling of the forehead. She was seen in a neurosurgery clinic and referred to our hospital. She had no past history of serious illnesses, operations or hospitalizations. On examination, there was a fixed firm mass, 13 cm in size, in the right side of the forehead. The skin on the center of the mass was stretched and took on a reddish hue. Neurological examination was negative. Blood chemistry tests showed lactate dehydrogenase four times above normal and a slight increase in alkaline phosphatase, amylase and lipase. Beta-2-microglobulin was normal. Bone windows of computed tomography (CT) of the head showed hyperostosis and permeative lytic changes of the frontal bone. Postcontrast MRI showed a large enhanced subgaleal lesion extending through the bony calvarium with a large subdural component. Histological examination after a biopsy was characteristic for a diffuse large B-cell lymphoma. Postcontrast CT of the abdomen and FDG-PET showed metastatic lesions in the pancreas, kidneys and cervical lymph nodes. The patient has been treated by CHOP chemotherapy and has been well. CONCLUSIONS We present a case of primary diffuse large B-cell lymphoma of the cranial vault. We recommend including this tumor variant in the differential diagnosis of rapid growing cranial vault tumors.


2012 ◽  
Vol 9 (2) ◽  
pp. 88-92 ◽  
Author(s):  
Kiara Rezaei-Kalantari ◽  
Kaveh Samimi ◽  
Maryam Jafari ◽  
Mohammad Ali Karimi ◽  
Keyvan Ansari ◽  
...  

Author(s):  
Mohd Faheem ◽  
◽  
Manish Jaiswal ◽  
Bal Krishna Ojha ◽  
Anil Chandra ◽  
...  

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