Silencing of the cell cycle checkpoint gene 14-3-3σ in basal cell carcinomas correlates with reduced expression of IKK-α

2013 ◽  
Vol 28 (8) ◽  
pp. 1113-1116 ◽  
Author(s):  
S. C. Molin ◽  
M. Grgic ◽  
T. Ruzicka ◽  
T. Herzinger
Keyword(s):  
Cell Cycle ◽  
Basal Cell ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Gene ◽  
Basal Cell Carcinomas ◽  
Cycle Checkpoint

Identification and Characterization of a Paralog of Human Cell Cycle Checkpoint Gene HUS1

Genomics ◽  
2002 ◽  
Vol 79 (4) ◽  
pp. 487-492 ◽  
Author(s):  
Haiying Hang ◽  
Yuzhu Zhang ◽  
Roland L. Dunbrack ◽  
Cuidong Wang ◽  
Howard B. Lieberman
Keyword(s):  
Cell Cycle ◽  
Human Cell ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Gene ◽  
Cycle Checkpoint ◽  
Identification And Characterization

scholarly journals hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation

Oncogene ◽  
1999 ◽  
Vol 18 (9) ◽  
pp. 1689-1699 ◽  
Author(s):  
Lei Li ◽  
Carolyn A Peterson ◽  
Gunilla Kanter-Smoler ◽  
Ying-Fei Wei ◽  
Louis S Ramagli ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Schizosaccharomyces Pombe ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Gene ◽  
Cycle Checkpoint

Mouse Hus1, a Homolog of the Schizosaccharomyces pombe hus1+ Cell Cycle Checkpoint Gene

Genomics ◽  
1999 ◽  
Vol 59 (1) ◽  
pp. 32-39 ◽  
Author(s):  
Robert S. Weiss ◽  
Corwin F. Kostrub ◽  
Tamar Enoch ◽  
Philip Leder
Keyword(s):  
Cell Cycle ◽  
Schizosaccharomyces Pombe ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Gene ◽  
Cycle Checkpoint

scholarly journals IKKα Shields 14-3-3σ, a G2/M Cell Cycle Checkpoint Gene, from Hypermethylation, Preventing Its Silencing

2007 ◽  
Vol 27 (2) ◽  
pp. 214-227 ◽  
Author(s):  
Feng Zhu ◽  
Xiaojun Xia ◽  
Bigang Liu ◽  
Jianjun Shen ◽  
Yuhui Hu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Checkpoint ◽  
M Cell ◽  
Checkpoint Gene ◽  
Cycle Checkpoint

scholarly journals The Cell Cycle Checkpoint Gene Rad9 Is a Novel Oncogene Activated by 11q13 Amplification and DNA Methylation in Breast Cancer

2005 ◽  
Vol 65 (19) ◽  
pp. 8646-8654 ◽  
Author(s):  
Chi Keung Cheng ◽  
Louis W.C. Chow ◽  
Wings T.Y. Loo ◽  
Tai Kwong Chan ◽  
Vivian Chan
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Dna Methylation ◽  
Cell Cycle Checkpoint ◽  
Checkpoint Gene ◽  
Cycle Checkpoint ◽  
11Q13 Amplification

scholarly journals A novel mutant allele of Schizosaccharomyces pombe rad26 defective in monitoring S-phase progression to prevent premature mitosis.

1997 ◽  
Vol 17 (6) ◽  
pp. 3103-3115 ◽  
Author(s):  
M Uchiyama ◽  
I Galli ◽  
D J Griffiths ◽  
T S Wang
Keyword(s):  
Cell Cycle ◽  
Schizosaccharomyces Pombe ◽  
Dna Polymerase ◽  
S Phase ◽  
Cell Cycle Checkpoint ◽  
Gene Products ◽  
Dna Polymerase Delta ◽  
Checkpoint Gene ◽  
Cycle Checkpoint ◽  
Phase Progression

A semipermissive growth condition was defined for a Schizosaccharomyces pombe strain carrying a thermosensitive allele of DNA polymerase delta (pol delta ts03). Under this condition, DNA polymerase delta is semidisabled and causes a delay in S-phase progression. Using a genetic strategy, we have isolated a panel of mutants that enter premature mitosis when DNA replication is incomplete but which are not defective for arrest in G2/M following DNA damage. We characterized the aya14 mutant, which enters premature mitosis when S phase is arrested by genetic or chemical means. However, this mutant is sensitive to neither UV nor gamma irradiation. Two genomic clones, rad26+ and cds1+, were found to suppress the hydroxyurea sensitivity of the aya14 mutant. Genetic analysis indicates that aya14 is a novel allele of the cell cycle checkpoint gene rad26+, which we have named rad26.a14. cds1+ is a suppressor which suppresses the S-phase feedback control defect of rad26.a14 when S phase is inhibited by either hydroxyurea or cdc22, but it does not suppress the defect when S phase is arrested by a mutant DNA polymerase. Analyses of rad26.a14 in a variety of cdc mutant backgrounds indicate that strains containing rad26.a14 bypass S-phase arrest but not G1 or late S/G2 arrest. A model of how Rad26 monitors S-phase progression to maintain the dependency of cell cycle events and coordinates with other rad/hus checkpoint gene products in responding to radiation damage is proposed.

scholarly journals Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

2000 ◽  
Vol 10 (8) ◽  
pp. 479-482 ◽  
Author(s):  
A. de Klein ◽  
M. Muijtjens ◽  
R. van Os ◽  
Y. Verhoeven ◽  
B. Smit ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Checkpoint ◽  
Embryonic Lethality ◽  
Targeted Disruption ◽  
Checkpoint Gene ◽  
Early Embryonic Lethality ◽  
Cycle Checkpoint
Sign in / Sign up

Export Citation Format

Share Document