scholarly journals Association between cortisol and left ventricular diastolic dysfunction in patients with diabetes mellitus

2021 ◽  
Author(s):  
Rikako Sagara ◽  
Tomoaki Inoue ◽  
Noriyuki Sonoda ◽  
Chieko Yano ◽  
Misato Motoya ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Ventricular Diastolic Dysfunction ◽  
Patients With Diabetes

scholarly journals Association Between Cortisol and Left Ventricular Diastolic Dysfunction in Patients With Diabetes Mellitus: A Case Control Study

2021 ◽  
Author(s):  
RIKAKO SAGARA ◽  
Tomoaki Inoue ◽  
Noriyuki Sonoda ◽  
Chieko Yano ◽  
Misato Motoya ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Linear Regression Analysis ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
University Hospital ◽  
Multivariate Linear Regression Analysis ◽  
Diastolic Velocity ◽  
Ventricular Diastolic Dysfunction ◽  
Patients With Diabetes

Abstract Introduction: Diabetes mellitus (DM) is a major risk factor for the development of cardiovascular diseases. Heart failure with preserved ejection fraction is characterized by left ventricular diastolic dysfunction (LVDD). It has been reported that excess cortisol found in patients with Cushing’s syndrome was associated with the development of LVDD. However, the relationship between cortisol concentration and LVDD in patients with DM has not been addressed. Research Design and Methods: We enrolled 109 patients with DM and 104 patients without DM who had undergone echocardiographic examination at Kyushu University Hospital, Japan, between November 2016 and March 2019. Left ventricular function was evaluated and the ratio of early diastolic velocity from transmitral inflow to early diastolic velocity (E/eʹ) was used as an index of diastolic function. Plasma cortisol concentrations, glycemic control, lipid profiles, treatment with anti-diabetic drugs, and other clinical characteristics were evaluated, and their associations with E/eʹ were determined using univariate and multivariate analyses. Results Multivariate linear regression analysis showed that log E/eʹ was positively correlated with age (p = 0.017), log systolic blood pressure (p = 0.004), and cortisol (p = 0.037) and negatively correlated with eGFR (p = 0.016) and the usage of SGLT2 inhibitors (p = 0.042) in patients with DM. Multivariate analysis showed that cortisol was positively correlated with age (p = 0.016) and HbA1c (p = 0.011). There was no association between E/eʹ and cortisol in patients without DM. Conclusions Increased cortisol levels may increase the risk of developing LVDD in DM patients.

scholarly journals Echocardiographic evaluation of left ventricular diastolic dysfunction in recently diagnosed type 2 diabetes mellitus

2018 ◽  
Vol 6 (5) ◽  
pp. 1691
Author(s):  
Swapnil Jain ◽  
C. L. Nawal ◽  
Amandeep Singh ◽  
Radhey Shyam Chejara ◽  
Sagar Barasara ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
P Value ◽  
Diabetic Patients ◽  
Ventricular Diastolic Dysfunction

Background: Diastolic dysfunction in patients suffering from diabetes mellitus represents an earlier stage in the natural history of cardiomyopathy. This study was done to assess the left ventricular diastolic dysfunction in recently diagnosed (<5yr) Type 2 Diabetes Mellitus by Echocardiography and also to determine association of glycemic status (by HBA1c levels) with left ventricular diastolic dysfunction (LVDD).Methods: An observational descriptive study involving 100 diabetic patients, taken on first come first serve basis after applying inclusion and exclusion criteria. In all the subjects, other than routine investigations, HbA1c was estimated and echocardiography was done to evaluate LVDD.Results: Mean value of HbA1c in the study was 8.31+ 1.408 %. 63 out of 100 subjects had LVDD. There was significant positive correlation between HbA1c and LVDD (p value <0.001). As HbA1c increased, severity of LVDD increased. In this study, as BMI increased, HbA1c and LVDD increased & both findings were statistically significant (p value =0.001).Conclusion: Our study indicates that myocardial damage in patients with diabetes affects diastolic function before systolic function &higher HbA1C level is strongly associated with presence of LVDD. Patients should be advised strict control of diabetes in order to reduce the risk for developing LVDD which is a precursor for more advanced disease.Keywords: Diabetes mellitus, Diastolic dysfunction, BMI, HbA1c

scholarly journals Glycosylated hemoglobin and left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus

2017 ◽  
Vol 5 (12) ◽  
pp. 5330 ◽  
Author(s):  
Vishal S. Yesankar ◽  
Nalini R. Humaney
Keyword(s):  
Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Glycosylated Hemoglobin ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Type I ◽  
Type Ii ◽  
Chi Square ◽  
Ventricular Diastolic Dysfunction

Background: Diabetes mellitus is one of the most common diseases. Left ventricular diastolic dysfunction may represent the early stage of diabetic cardiomyopathy thus reinforcing the importance of the early examination of diastolic function in individuals with diabetes.Methods: This is a hospital based cross-sectional study done at a tertiary care hospital catering mainly to rural population. Patients having type 2 diabetes mellitus were scrutinized for doppler echocardiography and HbA1c levels. As per the previous studies and considering the prevalence of asymptomatic diastolic dysfunction in diabetics, the sample size was calculated. Statistical analysis was done by using descriptive and inferential statistics using chi square test.Results: In the present study 45 patients had HbA1C between 6.5- 8.0, out of which 9 had type I diastolic dysfunction, 1 had type II diastolic dysfunction and 35 had no diastolic dysfunction. 16 patients had HbA1C between 8.1- 9.5, out of which 7 had type I diastolic dysfunction, 8 had type II diastolic dysfunction and 1 had no diastolic dysfunction. 14 patients had HbA1C more than 9.5, out of which 4 had type I diastolic dysfunction, 5 had type II diastolic dysfunction, 4 had type III diastolic dysfunction and 1 patient did not had any diastolic dysfunction. The Chi-Square value is 55.51 and p value is 0.000 (Significant).Conclusions: Diastolic dysfunction correlates with the levels of glycosylated hemoglobin, duration of diabetes mellitus, presence of microvascular complications like diabetic retinopathy, neuropathy and nephropathy.

scholarly journals Prevalence of left ventricular diastolic dysfunction among patients with asymptomatic diabetes mellitus type 2

2019 ◽  
Vol 6 (4) ◽  
pp. 1032
Author(s):  
D. Sai Vittal ◽  
M. V. Ram Babu
Keyword(s):  
Diastolic Dysfunction ◽  
Diastolic Heart Failure ◽  
Strong Association ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Ventricular Diastolic Dysfunction ◽  
Patients With Diabetes ◽  
Onset Of Diabetes

Background: Diastolic heart failure occurs due to impaired myocardial relaxation and compliance. Of late, it has been suggested that the changes in the diastolic function occurs before the onset of diabetes, and present in the prediabetic patients. It is also said to be associated with insulin resistance.Methods: This observational study was performed on 50 diabetic patients, with asymptomatic type 2 diabetes. who came in for 2 D echocardiogram with suspected diastolic dysfunction.Results: The mean age among the 50 patients in the study was 54.1±10.99 years and in controls it was 49.56±10.63 years. The fasting sugar among the patients was 179.43±41.57 mg/dl and the post prandial was 236.72±76.24, and it was in the normal range in the controls. The HbA1c was 9.93±1.2 among the patients and 6.09 ± 0.34 in the controls. In the patients, the E/A ratio was 0.83±0.09 compared to 1.22±0.31 of the controls, which was highly significant as the E/e ratio which was 15.1±3.4 and 7.3±0.08 respectively.Conclusions: There was a higher prevalence of diastolic dysfunction among the patients with diabetes in our study. There was no relation of age or gender among the diabetic and the controls, while a strong association and indicators seem to be FBS, PLBS and HbA1c.

scholarly journals Association of Body Mass Index with Left Ventricular Diastolic Dysfunction Among Ambulatory Patients with Diabetes Mellitus in Rural Uganda: A Cross Sectional Study.

2021 ◽  
Author(s):  
Boniface Amanee Elias Lumori ◽  
Edwin Nuwagira ◽  
Fardous Charles Abeya ◽  
Abdirahman Ali Araye ◽  
Godfrey Masete ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Diastolic Dysfunction ◽  
Body Mass ◽  
Cross Sectional Study ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ventricular Diastolic Dysfunction

Abstract Background: Left ventricular diastolic dysfunction (LVDD) is a recognized complication of diabetes mellitus which precedes and is a risk factor for heart failure. We aimed to determine the prevalence of LVDD and its association with body mass index (BMI) in ambulatory adults with diabetes mellitus. Methods: We conducted a cross-sectional study of 195 ambulatory Ugandan adults living with diabetes mellitus for at least five years from the time of diagnosis at Mbarara Regional Referral Hospital (MRRH). We collected demographic, clinical data and measured body mass index. Laboratory tests included glycated hemoglobin (HbA1c), low-density lipoprotein (LDL), and urine microalbumin. Echocardiography was done to determine LVDD by assessing the mitral inflow E/A ratio, E/è ratio, TR jet peak velocity, and left atrium maximum volume index. Logistic regression was used to establish associations of body mass index and other covariates with LVDD. Results: Overall, 195 participants were enrolled and 141(72.3%) were females. The mean age was 62 [standard deviation (SD), 11.5] years and median duration of diabetes diagnosis was 10 [Interquartile range (IQR), 7,15] years. LVDD was prevalent at 86% and majority, 127(65.13%) had grade-1 diastolic dysfunction. BMI ≥25kg/m2 [adjusted Odds Ratio (aOR)=2.8, (95% confidence interval (CI)=1-7.6), p=0.038], age 50 year or more [aOR= 4.9, (95%CI=1.5-16.2), p=0.010], and history of hypertension [aOR= 3.0, (95% CI= 1.1-8.1), p=0.031] were associated with LVDD.Conclusion: The prevalence of LVDD was high during the study period. We recommend early and periodic echocardiographic screening for diabetes patients with high body mass index.

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