scholarly journals Can we catch the second loach employing BACE1 inhibition, even as the first one might be escaping?

2021 ◽  
Author(s):  
Hiraku Ono ◽  
Koutaro Yokote
Keyword(s):  
Bace1 Inhibition

P4-217: EFFECTS OF BACE1 INHIBITION ON ABETA IN RATS AND TG2576

2014 ◽  
Vol 10 ◽  
pp. P867-P867
Author(s):  
Cornelia Dorner-Ciossek ◽  
Scott Hobson ◽  
Martin Lenter ◽  
Yuri Bukhtiyarov ◽  
Deepak Lala
Keyword(s):  
Bace1 Inhibition

scholarly journals Can BACE1 Inhibition Mitigate Early Axonal Pathology in Neurological Diseases?

2013 ◽  
Vol 38 (4) ◽  
pp. 705-718 ◽  
Author(s):  
Xiao-Xin Yan ◽  
Chao Ma ◽  
Wei-Ping Gai ◽  
Huaibin Cai ◽  
Xue-Gang Luo
Keyword(s):  
Neurological Diseases ◽  
Axonal Pathology ◽  
Bace1 Inhibition

scholarly journals Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Claire S. Durrant ◽  
Karsten Ruscher ◽  
Olivia Sheppard ◽  
Michael P. Coleman ◽  
Ilknur Özen
Keyword(s):  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Vascular Pathology ◽  
Amyloid Precursor Protein Processing ◽  
Amyloid Beta Peptides ◽  
App Processing ◽  
Sprouting Angiogenesis ◽  
Organotypic Brain Slice ◽  
Bace1 Inhibition

AbstractAmyloid beta peptides (Aβ) proteins play a key role in vascular pathology in Alzheimer’s Disease (AD) including impairment of the blood–brain barrier and aberrant angiogenesis. Although previous work has demonstrated a pro-angiogenic role of Aβ, the exact mechanisms by which amyloid precursor protein (APP) processing and endothelial angiogenic signalling cascades interact in AD remain a largely unsolved problem. Here, we report that increased endothelial sprouting in human-APP transgenic mouse (TgCRND8) tissue is dependent on β-secretase (BACE1) processing of APP. Higher levels of Aβ processing in TgCRND8 tissue coincides with decreased NOTCH3/JAG1 signalling, overproduction of endothelial filopodia and increased numbers of vascular pericytes. Using a novel in vitro approach to study sprouting angiogenesis in TgCRND8 organotypic brain slice cultures (OBSCs), we find that BACE1 inhibition normalises excessive endothelial filopodia formation and restores NOTCH3 signalling. These data present the first evidence for the potential of BACE1 inhibition as an effective therapeutic target for aberrant angiogenesis in AD.

Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition

2017 ◽  
Vol 13 (6) ◽  
pp. 701-709 ◽  
Author(s):  
Juliane Schelle ◽  
Lisa M. Häsler ◽  
Jens C. Göpfert ◽  
Thomas O. Joos ◽  
Hugo Vanderstichele ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Bace1 Inhibition

scholarly journals Comparison of Two Different Methods for Measurement of Amyloid-β Peptides in Cerebrospinal Fluid after BACE1 Inhibition in a Dog Model

2013 ◽  
Vol 38 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Herman Borghys ◽  
Tom Jacobs ◽  
Bianca Van Broeck ◽  
Lieve Dillen ◽  
Deborah Dhuyvetter ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Amyloid Β ◽  
Dog Model ◽  
Bace1 Inhibition

P4-084: Suppression of TAU Increase in Cerebrospinal Fluid of App Transgenic Mice Provides Evidence for Downstream Effect of Bace1 Inhibition

2016 ◽  
Vol 12 ◽  
pp. P1045-P1045
Author(s):  
Stephan A. Kaeser ◽  
Juliane Schelle ◽  
Lisa Haesler ◽  
Jens C. Goepfert ◽  
Thomas O. Joos ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Transgenic Mice ◽  
Bace1 Inhibition

P4-265: BACE1 inhibition reduces Abeta production and alters APP processing in non-transgenic mice

2006 ◽  
Vol 2 ◽  
pp. S594-S594
Author(s):  
Gaku Sakaguchi ◽  
Kouhei Nishitomi ◽  
Yuko Horikoshi ◽  
Yoshihiro Nakajima ◽  
Motoko Hosono ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
App Processing ◽  
Abeta Production ◽  
Bace1 Inhibition
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