scholarly journals A Low Fasting Glucose/Estimated Average Glucose Ratio was Associated with Superior Response to Insulin Degludec/Aspart Compared to Basal Insulin in Patients with Type 2 Diabetes

2021 ◽  
Author(s):  
Han Na Jang ◽  
Ye Seul Yang ◽  
Tae Jung Oh ◽  
Bo Kyung Koo ◽  
Seong Ok Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Basal Insulin ◽  
Fasting Glucose ◽  
Insulin Degludec ◽  
Glucose Ratio ◽  
Average Glucose

725-P: Low Fasting Glucose and Insulin Deficiency Were Related with Superiority of Insulin Degludec/Aspart Compared with Basal Insulin in Patients with Type 2 Diabetes

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 725-P
Author(s):  
HAN NA JANG ◽  
YE SEUL YANG ◽  
TAE JUNG OH ◽  
BO KYUNG KOO ◽  
SEONGOK LEE ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Basal Insulin ◽  
Fasting Glucose ◽  
Insulin Degludec ◽  
Insulin Deficiency

scholarly journals Advances in Basal Insulin Therapy

2016 ◽  
Vol 32 (6) ◽  
pp. 260-268
Author(s):  
Jennifer Goldman ◽  
John R. White
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Glargine ◽  
Basal Insulin ◽  
Data Extraction ◽  
The United States ◽  
Insulin Degludec ◽  
Study Selection ◽  
Meta Analyses

Objective: To review 2 new basal insulin analogs that have been approved in the United States for use in type 1 and type 2 diabetes—insulin glargine 300 units/mL and insulin degludec 100 units/mL and 200 units/mL. Data Sources: PubMed was searched using the terms “insulin glargine 300 units/mL,” “Gla-300,” “insulin degludec,” “IDeg,” “insulin degludec 200 units/mL,” and “insulin degludec 100 units/mL” for articles published between 1995 and May 2016. Study Selection and Data Extraction: Clinical trials, meta-analyses and subanalyses were identified; review articles were excluded. Relevant citations from identified articles were also reviewed. Data Synthesis: The new basal insulins, insulin glargine 300 units/mL and insulin degludec 100 units/mL and 200 units/mL, have improved pharmacokinetic and pharmacodynamic profiles compared to insulin glargine 100 units/mL. All demonstrate longer durations of action, beyond 24 hours, and less variability. These improved profiles translate into comparable A1C reductions and comparable, or improved, levels of hypoglycemia compared to insulin glargine 100 units/mL. Conclusions: These benefits may lead to improved glycemic control in a range of patients with type 1 and type 2 diabetes with true once-daily dosing.

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