scholarly journals Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients

Author(s):  
Bruno Vergès ◽  
Alexia Rouland ◽  
Sabine Baillot‐Rudoni ◽  
Marie‐Claude Brindisi ◽  
Laurence Duvillard ◽  
...  
2011 ◽  
Vol 147 (2) ◽  
pp. 335-336 ◽  
Author(s):  
Małgorzata Waluś-Miarka ◽  
Barbara Katra ◽  
Danuta Fedak ◽  
Danuta Czarnecka ◽  
Przemysław Miarka ◽  
...  

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1019-P
Author(s):  
YUKI FUJITA ◽  
SODAI KUBOTA ◽  
HITOSHI KUWATA ◽  
DAISUKE YABE ◽  
YOSHIYUKI HAMAMOTO ◽  
...  

2002 ◽  
Vol 39 (3) ◽  
pp. 105-110 ◽  
Author(s):  
S. Fischer ◽  
M. Hanefeld ◽  
S. M. Haffner ◽  
C. Fusch ◽  
U. Schwanebeck ◽  
...  

2020 ◽  
Vol 75 (2) ◽  
pp. 189-195 ◽  
Author(s):  
Yutaka Hatani ◽  
Hidekazu Tanaka ◽  
Yasuhide Mochizuki ◽  
Makiko Suto ◽  
Shun Yokota ◽  
...  

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Ruo-Yao Gao ◽  
Bang-Gee Hsu ◽  
Du-An Wu ◽  
Jia-Sian Hou ◽  
Ming-Chun Chen

Background. Fibroblast growth factor 21 (FGF21) acts as a potent metabolic regulator. Serum FGF21 levels were significantly higher in obesity and type 2 diabetes mellitus (T2DM) populations. The aim of this study was to evaluate the relationship between serum FGF21 levels and metabolic syndrome (MetS) in T2DM patients. Methods. Fasting blood samples were obtained from 126 T2DM patients. MetS and its components were defined according to the diagnostic criteria from the International Diabetes Federation. Serum FGF21 concentrations were measured using a commercially available enzyme-linked immunosorbent assay. Results. Among these patients, 84 (66.7%) had MetS. Female gender, hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), body weight (BW), body mass index (BMI), body fat mass, fasting glucose, glycated hemoglobin level (HbA1c), triglyceride level (TG), urine albumin-to-creatinine ratio (UACR), insulin level, homeostasis model assessment of insulin resistance (HOMA-IR), and FGF21 levels were higher, whereas high-density lipoprotein cholesterol level (HDL-C) and estimated glomerular filtration rate (eGFR) were lower in DM patients with MetS. Univariate linear analysis revealed that hypertension, BMI, WC, body fat mass, SBP, DBP, logarithmically transformed TG (log-TG), low-density lipoprotein cholesterol (LDL-C) level, log-glucose, log-creatinine, log-UACR, log-insulin, and log-HOMA-IR positively correlated, whereas HDL-C and eGFR negatively correlated with serum FGF21 levels in T2DM patients. Multivariate forward stepwise linear regression analysis revealed that body fat mass (adjusted R2 change = 0.218; P=0.008) and log-TG (adjusted R2 change = 0.036; P<0.001) positively correlated, whereas eGFR (adjusted R2 change = 0.033; P=0.013) negatively correlated with serum FGF21 levels in T2DM patients. Conclusions. This study showed that higher serum FGF21 levels were positively associated with MetS in T2DM patients and significantly positively related to body fat mass and TG but negatively related to eGFR in these subjects.


2021 ◽  
pp. 1-28
Author(s):  
Lijun Zhao ◽  
Xiao Tong Teong ◽  
Kai Liu ◽  
Bo Liu ◽  
Yohannes A Melaku ◽  
...  

Abstract Eating architecture is a term that describes meal frequency, meal timing, and meal size and the daily variation in each of these. The aim of this study was to determine the relationship between components of eating architecture on body fat and markers of glycaemic control in healthy adults at increased risk of type 2 diabetes (T2DM). Participants (N=73, 39 males, age 58.8 [8.1] years, BMI 33.4 [4.4] kg/m2) recorded food intake and wore accelerometers and continuous glucose monitors (CGM) for 7-14 days under free-living conditions. Body fat and glycated haemoglobin (HbA1c) were also measured. The mean and day-to-day variation (calculated as the standard deviation during the monitoring period) of each component of eating architecture were calculated. Multivariable linear regression models were constructed for three separate outcome variables (body fat mass, mean CGM glucose, and HbA1c) for each component of eating architecture before and after adjustment for confounders. Higher variability in the time of first meal consumption was associated with increased body fat mass after adjusting for confounders (β=0.227, 95% CI: 0.019, 0.434, p=0.033). Increased variability in the time lag from waking to first meal consumption was also positively associated with increased HbA1c after adjustment (β=0.285, 95%CI: 0.040, 0.530, p=0.023). Low day-to-day variability in first meal consumption was associated with lower body fat and improved glucose control in adults at increased risk of T2DM. Routine consumption of meals may optimise temporal regulation to anticipate and respond appropriately to a glucose challenge.


2019 ◽  
Vol 73 (9) ◽  
pp. 1498
Author(s):  
Yutaka Hatani ◽  
Hidekazu Tanaka ◽  
Yasuhide Mochizuki ◽  
Makiko Suto ◽  
Hiroki Takada ◽  
...  

2021 ◽  
Vol 4 (1) ◽  
pp. e2033457 ◽  
Author(s):  
Steven B. Heymsfield ◽  
Laura A. Coleman ◽  
Ram Miller ◽  
Daniel S. Rooks ◽  
Didier Laurent ◽  
...  

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