scholarly journals Advancements in transplantation therapy for diabetes: Pancreas, islet and stem cell

2020 ◽  
Author(s):  
Toshihiro Nakamura ◽  
Junji Fujikura ◽  
Nobuya Inagaki
Keyword(s):  
Stem Cell ◽  
Pancreas Islet ◽  
Transplantation Therapy

scholarly journals Preconditioned and Genetically Modified Stem Cells for Myocardial Infarction Treatment

2020 ◽  
Vol 21 (19) ◽  
pp. 7301 ◽  
Author(s):  
Kamila Raziyeva ◽  
Aiganym Smagulova ◽  
Yevgeniy Kim ◽  
Saltanat Smagul ◽  
Ayan Nurkesh ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Heart Function ◽  
Cellular Reprogramming ◽  
Genetic Manipulations ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy

Ischemic heart disease and myocardial infarction remain leading causes of mortality worldwide. Existing myocardial infarction treatments are incapable of fully repairing and regenerating the infarcted myocardium. Stem cell transplantation therapy has demonstrated promising results in improving heart function following myocardial infarction. However, poor cell survival and low engraftment at the harsh and hostile environment at the site of infarction limit the regeneration potential of stem cells. Preconditioning with various physical and chemical factors, as well as genetic modification and cellular reprogramming, are strategies that could potentially optimize stem cell transplantation therapy for clinical application. In this review, we discuss the most up-to-date findings related to utilizing preconditioned stem cells for myocardial infarction treatment, focusing mainly on preconditioning with hypoxia, growth factors, drugs, and biological agents. Furthermore, genetic manipulations on stem cells, such as the overexpression of specific proteins, regulation of microRNAs, and cellular reprogramming to improve their efficiency in myocardial infarction treatment, are discussed as well.

scholarly journals Adipose-derived stem cell sheet transplantation therapy in a porcine model of chronic heart failure

2015 ◽  
Vol 165 (5) ◽  
pp. 631-639 ◽  
Author(s):  
Osamu Ishida ◽  
Ikuo Hagino ◽  
Noritoshi Nagaya ◽  
Tatsuya Shimizu ◽  
Teruo Okano ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cell ◽  
Chronic Heart Failure ◽  
Porcine Model ◽  
Cell Sheet ◽  
Adipose Derived Stem Cell ◽  
Transplantation Therapy

scholarly journals Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

2017 ◽  
Vol 157 ◽  
pp. 49-78 ◽  
Author(s):  
Ling Wei ◽  
Zheng Z. Wei ◽  
Michael Qize Jiang ◽  
Osama Mohamad ◽  
Shan Ping Yu
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Benefits ◽  
Cell Transplantation Therapy ◽  
Transplantation Therapy
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