scholarly journals Juvenile case with the coexistence of maturity‐onset diabetes of the young 1 and later‐onset latent autoimmune diabetes in youth

2020 ◽  
Vol 11 (4) ◽  
pp. 1010-1013
Author(s):  
Kei Yoshida ◽  
Tatsuhiko Urakami ◽  
Yusuke Mine ◽  
Remi Kuwabara ◽  
Ichiro Morioka
Keyword(s):  
Autoimmune Diabetes ◽  
Maturity Onset Diabetes ◽  
Latent Autoimmune Diabetes ◽  
Onset Diabetes ◽  
Diabetes In Youth

scholarly journals Maturity-Onset Diabetes of the Young (MODY) Mutation in Type 2 Diabetes and Latent Autoimmune Diabetes of the Adult

Diabetes Care ◽  
2003 ◽  
Vol 26 (12) ◽  
pp. 3358-3359 ◽  
Author(s):  
J. McKinney ◽  
H. Cao ◽  
M. T. Behme ◽  
J. L. Mahon ◽  
R. A. Hegele
Keyword(s):  
Type 2 Diabetes ◽  
Autoimmune Diabetes ◽  
Maturity Onset Diabetes ◽  
Latent Autoimmune Diabetes ◽  
Onset Diabetes

scholarly journals Tunisian Maturity-Onset Diabetes of the Young: A Short Review and a New Molecular and Clinical Investigation

2021 ◽  
Vol 12 ◽  
Author(s):  
Mariam Moalla ◽  
Wajdi Safi ◽  
Maab Babiker Mansour ◽  
Mohamed Hadj Kacem ◽  
Mona Mahfood ◽  
...  
Keyword(s):  
Autoimmune Diabetes ◽  
Clinical Investigation ◽  
Direct Sequencing ◽  
Short Review ◽  
Tunisian Population ◽  
Maturity Onset Diabetes ◽  
Clinical Criteria ◽  
Pathogenic Variants ◽  
Onset Diabetes ◽  
And Function

Introduction/AimsMaturity-Onset Diabetes of the Young (MODY) is a monogenic non-autoimmune diabetes with 14 different genetic forms. MODY-related mutations are rarely found in the Tunisian population. Here, we explored MODY related genes sequences among seventeen unrelated Tunisian probands qualifying the MODY clinical criteria.Materials and MethodsThe GCK and HNF1A genes were systematically analyzed by direct sequencing in all probands. Then, clinical exome sequencing of 4,813 genes was performed on three unrelated patients. Among them, 130 genes have been reported to be involved in the regulation of glucose metabolism, β-cell development, differentiation and function. All identified variants were analyzed according to their frequencies in the GnomAD database and validated by direct sequencing.ResultsWe identified the previously reported GCK mutation (rs1085307455) in one patient. The clinical features of the MODY2 proband were similar to previous reports. In this study, we revealed rare and novel alterations in GCK (rs780806456) and ABCC8 (rs201499958) genes with uncertain significance. We also found two likely benign alterations in HNF1A (rs1800574) and KLF11 (rs35927125) genes with minor allele frequencies similar to those depicted in public databases. No pathogenic variants have been identified through clinical exome analysis.ConclusionsThe most appropriate patients were selected, following a strict clinical screening approach, for genetic testing. However, the known MODY1-13 genes could not explain most of the Tunisian MODY cases, suggesting the involvement of unidentified genes in the majority of Tunisian affected families.

168-LB: Latent Autoimmune Diabetes in Youth (15–29 Years Old): The Heavier End of an Autoimmune Disease Spectrum

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 168-LB
Author(s):  
JIN CHENG ◽  
XIAOHAN TANG ◽  
XIANG YAN ◽  
SHUOMING LUO ◽  
XIA LI ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Autoimmune Diabetes ◽  
Latent Autoimmune Diabetes ◽  
Disease Spectrum ◽  
Diabetes In Youth
Sign in / Sign up

Export Citation Format

Share Document