scholarly journals Effects of chromium malate on glycometabolism, glycometabolism‐related enzyme levels and lipid metabolism in type 2 diabetic rats: A dose–response and curative effects study

2015 ◽  
Vol 6 (4) ◽  
pp. 396-407 ◽  
Author(s):  
Weiwei Feng ◽  
Guanghua Mao ◽  
Qian Li ◽  
Wei Wang ◽  
Yao Chen ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Dose Response ◽  
Diabetic Rats ◽  
Related Enzyme ◽  
Chromium Malate ◽  
Type 2 Diabetic

scholarly journals Type 2 Diabetic Rats on Diet Supplemented With Chromium Malate Show Improved Glycometabolism, Glycometabolism-Related Enzyme Levels and Lipid Metabolism

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0125952 ◽  
Author(s):  
Weiwei Feng ◽  
Ting Zhao ◽  
Guanghua Mao ◽  
Wei Wang ◽  
Yun Feng ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Diabetic Rats ◽  
Related Enzyme ◽  
Chromium Malate ◽  
Type 2 Diabetic

scholarly journals Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF-β Signaling Pathway Activation in Type 2 Diabetic Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Biyu Hou ◽  
Yuerong Zhao ◽  
Guifen Qiang ◽  
Xiuying Yang ◽  
Chunyang Xu ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Liver Injury ◽  
Signaling Pathway ◽  
Hepatic Steatosis ◽  
Diabetic Rats ◽  
Lipid Metabolism Disorder ◽  
Smad Signaling ◽  
Metabolism Disorder ◽  
Type 2 Diabetic

Lipid metabolism disorder and inflammation are essential promoters in pathogenesis of liver injury in type 2 diabetes. Puerarin (PUR) has been reported to exert beneficial effects on many diabetic cardiovascular diseases and chemical-induced liver injuries, but its effects on diabetic liver injury and its mechanism are still unclear. The current study was designed to explore the therapeutic effect and mechanism of PUR on liver injury in a type 2 diabetic rat model induced by a high-fat diet combined with low-dose streptozotocin. The diabetic rats were treated with or without PUR (100 mg/kg/day) by gavaging for 8 weeks, and biochemical and histological changes in liver were examined. Results showed that treatment with PUR significantly attenuated hepatic steatosis by regulating blood glucose and ameliorating lipid metabolism disorder. Liver fibrosis was relieved by PUR treatment. PUR inhibited oxidative stress and inflammation which was associated with inactivation of NF-κB signaling, thereby blocking the upregulation of proinflammatory cytokines (IL-1β, TNF-α) and chemokine (MCP-1). This protection of PUR on diabetic liver injury is possibly related with inhibition on TGF-β/Smad signaling. In conclusion, the present study provides evidence that PUR attenuated type 2 diabetic liver injury by inhibiting NF-κB-driven liver inflammation and the TGF-β/Smad signaling pathway.

Arctium lappa L. polysaccharide can regulate lipid metabolism in type 2 diabetic rats through the SREBP-1/SCD-1 axis

2020 ◽  
Vol 494 ◽  
pp. 108055
Author(s):  
Min Chen ◽  
Jingge Xu ◽  
Yan Wang ◽  
Zhen Wang ◽  
Lanping Guo ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Diabetic Rats ◽  
Arctium Lappa ◽  
Type 2 Diabetic ◽  
Regulate Lipid Metabolism

Umbelliferone Improves an Impaired Glucose and Lipid Metabolism in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetic Rats

2015 ◽  
Vol 29 (9) ◽  
pp. 1388-1395 ◽  
Author(s):  
Jarinyaporn Naowaboot ◽  
Nuntiya Somparn ◽  
Suphaket Saentaweesuk ◽  
Patchareewan Pannangpetch
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose And Lipid Metabolism ◽  
Type 2 Diabetic

scholarly journals Effect of Stay-Green Wheat, a Novel Variety of Wheat in China, on Glucose and Lipid Metabolism in High-Fat Diet Induced Type 2 Diabetic Rats

Nutrients ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 5143-5155 ◽  
Author(s):  
Jinshan Ji ◽  
Chao Zhang ◽  
Xiaoqin Luo ◽  
Li Wang ◽  
Ruijuan Zhang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Diabetic Rats ◽  
High Fat ◽  
Stay Green ◽  
Glucose And Lipid Metabolism ◽  
Type 2 Diabetic
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