Beneficial effects of Wuzhi Capsule on tacrolimus blood concentrations in liver transplant patients with different donor‐recipient CYP3A5 genotypes

2021 ◽  
Author(s):  
Kai Kou ◽  
Xiaodong Sun ◽  
Mingqian Li ◽  
Ting Li ◽  
Yuelei Hu ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Blood Concentrations ◽  
Beneficial Effects ◽  
Transplant Patients ◽  
Wuzhi Capsule

scholarly journals Beneficial effects of traditional Chinese medicine Wuzhi Capsule on tacrolimus dose requirements in liver transplant patients with different donor-recipient CYP3A5 genotypes

2021 ◽  
Author(s):  
Kai Kou ◽  
Xiaodong Sun ◽  
Mingqian Li ◽  
Ting Li ◽  
Yuelei Hu ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Allograft Rejection ◽  
Animal Studies ◽  
Dose Requirement ◽  
Blood Concentrations ◽  
Beneficial Effects ◽  
Chinese Herbal ◽  
Transplant Patients ◽  
Wuzhi Capsule ◽  
Tacrolimus Dose

Abstract Background/Aims: Tacrolimus (Tac) is an immunosuppressant that is widely used to prevent allograft rejection in patients after liver transplantation. Recently, a Chinese herbal medicine known as Wuzhi Capsule (WZC) was shown to increase Tac blood concentrations by inhibiting the activity of CYP3A5 in animal studies in rats. To date, it remains unexplored whether WZC can be used to reduce the dose requirement for Tac in liver transplant patients with different donor-recipient CYP3A5 genotypes. Materials and Methods: A total of 185 liver transplant patients were enrolled and were divided into four groups according to the combinations of donor-recipient CYP3A5 phenotypes. WZC was given to patients who had C0/D of Tac ≤ 1 ng/ml per mg and required a dose of Tac ≥ 4 mg. Results: The R+/D+ group had the lowest C0, C0/D, and C0/D/W among the four groups. Furthermore, a larger proportion of patients in the CYP3A5 expression groups required Tac dose adjustment to achieve a therapeutic effect and were given Tac with WZC. Notably, the use of WZC significantly increased the blood concentrations of Tac in the CYP3A5 expression groups. Conclusion: WZC significantly increased the C0, C0/D, and C0/D/W in the CYP3A5 expression groups.

Clinical Utility of Monitoring Tacrolimus Blood Concentrations in Liver Transplant Patients

2001 ◽  
Vol 41 (5) ◽  
pp. 542-551 ◽  
Author(s):  
Raman Venkataramanan ◽  
Leslie M. Shaw ◽  
Laszlo Sarkozi ◽  
Richard Mullins ◽  
John Pirsch ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Clinical Utility ◽  
Blood Concentrations ◽  
Transplant Patients

Epidemiological Pattern, Incidence and Outcomes of COVID-19 in Liver Transplant Patients

2020 ◽  
Author(s):  
Jordi Colmenero ◽  
Manuel Rodriguez-Perálvarez ◽  
Magdalena Salcedo ◽  
Ana Arias-Milla ◽  
Alejandro Muñoz-Serrano ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Transplant Patients ◽  
Epidemiological Pattern

Suicide in Liver Transplant Patients

1994 ◽  
Vol 35 (6) ◽  
pp. 574-578 ◽  
Author(s):  
Anne Marie Riether ◽  
Elizabeth Mahler
Keyword(s):  
Liver Transplant ◽  
Transplant Patients

Real life experience of mycophenolate mofetil monotherapy in liver transplant patients

2020 ◽  
pp. 101451
Author(s):  
Guillaume Lassailly ◽  
Jerome Dumortier ◽  
Franck Saint-Marcoux ◽  
Medhi El Amrani ◽  
Juliette Boulanger ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Liver Transplant ◽  
Life Experience ◽  
Real Life ◽  
Transplant Patients
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