Association of MTHFR and ABCB1 polymorphisms with MTX‐induced mucositis in Chinese paediatric patients with acute lymphoblastic leukaemia, lymphoma or osteosarcoma—A retrospective cohort study

2021 ◽  
Author(s):  
Yan Gong ◽  
Li Luo ◽  
Liu Wang ◽  
Jun Chen ◽  
Fen Chen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Paediatric Patients

scholarly journals Factors associated with the time to return negative RT-PCR from COVID-19 in paediatric patients: a retrospective cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e052609
Author(s):  
Jianbo Shao ◽  
Hong Xu ◽  
Zhixi Liu ◽  
Xiaohua Ying ◽  
Hua Xu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Outcome Measures ◽  
Clinical Features ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Antiviral Drugs ◽  
Secondary Outcome ◽  
Rt Pcr ◽  
Factors Associated ◽  
Paediatric Patients

ObjectiveThis study aimed to describe the epidemiological and clinical features and potential factors related to the time to return negative reverse transcriptase (RT)-PCR in discharged paediatric patients with COVID-19.DesignRetrospective cohort study.SettingUnscheduled admissions to 12 tertiary hospitals in China.ParticipantsTwo hundred and thirty-three clinical charts of paediatric patients with confirmed diagnosis of COVID-19 admitted from 1 January 2020 to 17 April 2020.Primary and secondary outcome measuresPrimary outcome measures: factors associated with the time to return negative RT-PCR from COVID-19 in paediatric patients. Secondary outcome measures: epidemiological and clinical features and laboratory results in paediatric patients.ResultsThe median age of patients in our cohort was 7.50 (IQR: 2.92–12.17) years, and 133 (57.1%) patients were male. 42 (18.0%) patients were evaluated as asymptomatic, while 162 (69.5%) and 25 (10.7%) patients were classified as mild or moderate, respectively. In Cox regression analysis, longer time to negative RT-PCR was associated with the presence of confirmed infection in family members (HR (95% CI): 0.56 (0.41 to 0.79)). Paediatric patients with emesis symptom had a longer time to return negative (HR (95% CI): 0.33 (0.14 to 0.78)). During hospitalisation, the use of traditional Chinese medicine (TCM) and antiviral drugs at the same time is less conducive to return negative than antiviral drugs alone (HR (95% CI): 0.85 (0.64 to 1.13)).ConclusionsThe mode of transmission might be a critical factor determining the disease severity of COVID-19. Patients with emesis symptom, complications or confirmed infection in family members may have longer healing time than others. However, there were no significant favourable effects from TCM when the patients have received antiviral treatment.

scholarly journals Malnutrition in paediatric patients with leukaemia and lymphoma: a retrospective cohort study

2021 ◽  
Vol 15 ◽  
Author(s):  
Hardenson Rodríguez González ◽  
Sergio Andrade Mejía ◽  
Javier Orlando Contreras Ortiz ◽  
Adriana Patricia Osorno Gutiérrez ◽  
Jorge Eliécer Botero López ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Paediatric Patients

scholarly journals Treatment of haemangiomas using propranolol in paediatric patients: a retrospective cohort study

2020 ◽  
Vol 37 (4) ◽  
pp. 603-607 ◽  
Author(s):  
Przemysław Gałązka ◽  
Weronika Bereźnicka ◽  
Kamil Leis ◽  
Patryk Kaczor ◽  
Irena Daniluk-Matraś ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Paediatric Patients

Tu1788 CLINICAL CHARACTERISTICS AND TREATMENT DIFFERENCES BETWEEN YOUNGER AND OLDER ONSET MICROSCOPIC COLITIS: A MULTICENTER RETROSPECTIVE COHORT STUDY

2020 ◽  
Vol 158 (6) ◽  
pp. S-1161
Author(s):  
Amrit K. Kamboj ◽  
Amandeep Gujral ◽  
Elida Voth ◽  
Daniel Penrice ◽  
Jessica McGoldrick ◽  
...  
Keyword(s):  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Clinical Characteristics ◽  
Microscopic Colitis
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