Combination therapy for disseminated strongyloidiasis with associated vancomycin‐resistant, linezolid‐intermediate Enterococcus faecium meningitis: A case report

2021 ◽  
Author(s):  
Morgan A. Tobin ◽  
David F. Dougherty ◽  
Patrick D. Ratliff ◽  
W. Russ Judd
Keyword(s):  
Case Report ◽  
Combination Therapy ◽  
Enterococcus Faecium ◽  
Disseminated Strongyloidiasis ◽  
Vancomycin Resistant

scholarly journals β-Lactams Enhance Daptomycin Activity against Vancomycin-Resistant Enterococcus faecalis and Enterococcus faecium inIn VitroPharmacokinetic/Pharmacodynamic Models

2015 ◽  
Vol 59 (5) ◽  
pp. 2842-2848 ◽  
Author(s):  
Jordan R. Smith ◽  
Katie E. Barber ◽  
Animesh Raut ◽  
Michael J. Rybak
Keyword(s):  
Body Weight ◽  
Combination Therapy ◽  
Enterococcus Faecalis ◽  
Enterococcus Faecium ◽  
Single Agent ◽  
Vancomycin Resistant Enterococcus ◽  
Content Type ◽  
Vancomycin Resistant ◽  
Combination Regimens

ABSTRACTEnterococcus faecalisandEnterococcus faeciumare frequently resistant to vancomycin and β-lactams. In enterococcal infections with reduced glycopeptide susceptibility, combination therapy is often administered. Our objective was to conduct pharmacokinetic/pharmacodynamic (PK/PD) models to evaluate β-lactam synergy with daptomycin (DAP) against resistant enterococci. OneE. faecalisstrain (R6981) and twoE. faeciumstrains (R6370 and 8019) were evaluated. DAP MICs were obtained. All strains were evaluated for response to LL37, an antimicrobial peptide, in the presence and absence of ceftaroline (CPT), ertapenem (ERT), and ampicillin (AMP). After 96 h,in vitromodels were run simulating 10 mg DAP/kg body weight/day, 600 mg CPT every 8 h (q8h), 2 g AMP q4h, and 1 g ERT q24h, both alone and in combination against all strains. DAP MICs were 2, 4, and 4 μg/ml for strains R6981, R6370, and 8019, respectively. PK/PD models demonstrated bactericidal activity with DAP-CPT, DAP-AMP, and DAP-ERT combinations against strain 8019 (P< 0.001 and log10CFU/ml reduction of >2 compared to any single agent). Against strains R6981 and R6370, the DAP-AMP combination demonstrated enhancement against R6370 but not R6981, while the combinations of DAP-CPT and DAP-ERT were bactericidal, demonstrated enhancement, and were statistically superior to all other regimens at 96 h (P< 0.001) against both strains. CPT, ERT, and AMP similarly augmented LL37 killing against strain 8019. In strains R6981 and R6370, CPT and ERT aided LL37 more than AMP (P< 0.001). Compared to DAP alone, combination regimens provide better killing and prevent resistance. Clinical research involving DAP combinations is warranted.

scholarly journals Treatment of Multidrug-Resistant Vancomycin-Resistant Enterococcus faecium Hardware-Associated Vertebral Osteomyelitis with Oritavancin plus Ampicillin

2019 ◽  
Vol 63 (7) ◽  
Author(s):  
Samira Dahesh ◽  
Brian Wong ◽  
Victor Nizet ◽  
George Sakoulas ◽  
Truc T. Tran ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Antimicrobial Peptide ◽  
Continuous Infusion ◽  
Enterococcus Faecium ◽  
Vertebral Osteomyelitis ◽  
Multidrug Resistant ◽  
Vancomycin Resistant Enterococcus ◽  
Content Type ◽  
Vancomycin Resistant ◽  
Time Kill

ABSTRACT Weekly oritavancin plus ampicillin continuous infusion combination therapy was used to successfully treat a deep spine vancomycin-resistant Enterococcus faecium infection associated with hardware. Checkerboard and time-kill assays confirmed synergy between these two antibiotics. Further synergies of oritavancin and ampicillin with rifampin or the endogenous human antimicrobial peptide cathelicidin LL-37 were demonstrated.

scholarly journals Varying linezolid susceptibility of vancomycin-resistant Enterococcus faecium isolates during therapy: a case report

2005 ◽  
Vol 56 (4) ◽  
pp. 787-789 ◽  
Author(s):  
Stefanie Swoboda ◽  
Stefan Fritz ◽  
Marcus E. Martignoni ◽  
Rita A. Feldhues ◽  
Torsten Hoppe-Tichy ◽  
...  
Keyword(s):  
Case Report ◽  
Enterococcus Faecium ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant
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