Possible association of HMOX1 and NQO1 polymorphisms with anti-tuberculosis drug-induced liver injury: A matched case-control study

2019 ◽  
Vol 44 (4) ◽  
pp. 534-542 ◽  
Author(s):  
Miaomiao Yang ◽  
Haiping Zhang ◽  
Bilin Tao ◽  
Hongqiu Pan ◽  
Lihuan Lu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Case Control Study ◽  
Case Control ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

scholarly journals Acute and clinically relevant drug-induced liver injury: a population based case-control study

2004 ◽  
Vol 58 (1) ◽  
pp. 71-80 ◽  
Author(s):  
Francisco J. de Abajo ◽  
Dolores Montero ◽  
Mariano Madurga ◽  
Luis A. Garcia Rodriguez
Keyword(s):  
Liver Injury ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Control Study

scholarly journals Association between genetic polymorphisms of NRF2, KEAP1, MAFF, MAFK and anti-tuberculosis drug-induced liver injury: a nested case-control study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Shixian Chen ◽  
Hongqiu Pan ◽  
Yongzhong Chen ◽  
Lihuan Lu ◽  
Xiaomin He ◽  
...  
Keyword(s):  
Liver Injury ◽  
Signaling Pathway ◽  
Genetic Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Tb Treatment ◽  
Nested Case Control ◽  
Control Study

Abstract Reactive metabolites of anti-tuberculosis (anti-TB) drugs can result in excessive reactive oxygen species (ROS), which are responsible for drug-induced liver injury. The nuclear factor erythroid 2-related factor 2 (Nrf2) - antioxidant response elements (ARE) (Nrf2-ARE) signaling pathway plays a crucial role in protecting liver cells from ROS, inducing enzymes such as phase II metabolizing enzymes and antioxidant enzymes. Based on a Chinese anti-TB treatment cohort, a nested case-control study was performed to explore the association between 13 tag single-nucleotide polymorphisms (tagSNPs) in the NRF2, KEAP1, MAFF, MAFK genes in Nrf2-ARE signaling pathway and the risk of anti-TB drug-induced liver injury (ATLI) in 314 cases and 628 controls. Conditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) after adjusting weight and usage of hepatoprotectant. Patients carrying the TC genotype at rs4243387 or haplotype C-C (rs2001350-rs6726395) in NRF2 were at an increased risk of ATLI (adjusted OR = 1.362, 95% CI: 1.017–1.824, P = 0.038; adjusted OR = 2.503, 95% CI: 1.273–4.921, P = 0.008, respectively), whereas patients carrying TC genotype at rs2267373 or haplotype C-G-C (rs2267373-rs4444637-rs4821767) in MAFF were at a reduced risk of ATLI (adjusted OR = 0.712, 95% CI: 0.532–0.953, P = 0.022; adjusted OR = 0.753, 95% CI: 0.587–0.965, P = 0.025, respectively). Subgroup analysis also detected a significant association between multiple tagSNPs (rs4821767 and rs4444637 in MAFF, rs4720833 in MAFK) and specific clinical patterns of liver injury under different genetic models. This study shows that genetic polymorphisms of NRF2, MAFF and MAFK may contribute to the susceptibility to ATLI in the Chinese anti-TB treatment population.

Nonsteroidal anti-inflammatory drug-induced liver injury: a case-control study in primary care

2004 ◽  
Vol 18 (2) ◽  
pp. 201-206 ◽  
Author(s):  
I. Lacroix ◽  
M. Lapeyre-Mestre ◽  
H. Bagheri ◽  
A. Pathak ◽  
J.L. Montastruc ◽  
...  
Keyword(s):  
Primary Care ◽  
Liver Injury ◽  
Case Control Study ◽  
Case Control ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Drug Induced Liver Injury ◽  
Anti Inflammatory ◽  
Control Study

scholarly journals Risk of acute and serious liver injury associated to nimesulide and other NSAIDs: data from drug‐induced liver injury case–control study in Italy

2016 ◽  
Vol 82 (1) ◽  
pp. 238-248 ◽  
Author(s):  
Monia Donati ◽  
Anita Conforti ◽  
Maria Carmela Lenti ◽  
Annalisa Capuano ◽  
Oscar Bortolami ◽  
...  
Keyword(s):  
Liver Injury ◽  
Case Control Study ◽  
Case Control ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Control Study
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