Tacrolimus interaction with oral oestrogen in kidney transplant recipients: A case-control study

2018 ◽  
Vol 43 (4) ◽  
pp. 513-518 ◽  
Author(s):  
M. Ghadimi ◽  
S. Dashti-Khavidaki ◽  
M. Shahali ◽  
M. Gohari ◽  
M.-R. Khatami ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Case Control Study ◽  
Case Control ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Control Study

scholarly journals 530. COVID-19 in kidney transplant recipients: Single-center experience and case-control study

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S332-S332
Author(s):  
Anna Hardesty ◽  
Aakriti Pandita ◽  
Yiyun Shi ◽  
Kendra Vieira ◽  
Ralph Rogers ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Case Control Study ◽  
Clinical Course ◽  
Case Series ◽  
Case Fatality ◽  
Case Control ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Transplant Patients ◽  
Control Study

Abstract Background Organ transplant recipients (OTR) are considered high-risk for morbidity and mortality from COVID-19. Case-fatality rates (CFR) vary significantly in different case series, and some patients were still hospitalized at the time of analyses. To our knowledge, no case-control study of COVID-19 in OTR has been published to-date. Methods We captured kidney transplant recipients (KTR) diagnosed with COVID-19 between 3/1 and 5/18/2020. After exclusion of KTR on hemodialysis and off immunosuppression (IS), we compared the clinical course of COVID-19 between hospitalized KTR and non-transplant patients, matched by sex and age (controls). All patients were discharged from the hospital or died. Results 16 KTR had COVID-19. All 3 KTR off IS, who were excluded from further analyses, survived. Median age was 54 (range: 34–65) years; 5/13 KTR (38.4%) were men. Median time from transplant was 41 (range: 1–203) months. Two KTR, both transplanted >10 years ago, were managed as outpatients. IS was reduced in 12/13 (92.3%), most often by discontinuation of the antimetabolite. IL6 levels were >1,000 (normal: < 5) pg/mL in 3 KTR. Tacrolimus or sirolimus levels were >10 ng/mL in 6/9 KTR (67%) (Table 1). Eleven KTR were hospitalized (84.6%) and matched with 44 controls. One KTR, the only one treated with hydroxychloroquine, died (CFR 5.8%; 7.6% in KTR on IS; 9% in hospitalized KTR on IS). Four controls died (CFR: 9%; state CFR: 5.2%; inpatient CFR: 16.6%). There were no significant differences in length of stay or worst oxygenation status between hospitalized KTR and controls. Four KTR (30.7%), received remdesivir, 4 convalescent plasma, 3 (23%) tocilizumab. KTR received more often broad-spectrum antibiotics, convalescent plasma or tocilizumab, compared to controls (Table 2). Table 1 Table 2 Conclusion Unlike early reports from the pandemic epicenters, the clinical course and outcomes of KTR with COVID-19 in our small case series were comparable to those of non-transplant patients. Calcineurin or mTOR inhibitor levels were high, likely due to diarrhea and COVID-19-related hepatic dysfunction. Extremely high IL6 levels were common. The role of IS and potential benefits from investigational treatments remain to be elucidated. A larger multi-institutional study is underway. Disclosures All Authors: No reported disclosures

scholarly journals Severe Strongyloides stercoralis infection in kidney transplant recipients: A multicenter case-control study

2020 ◽  
Vol 14 (1) ◽  
pp. e0007998 ◽  
Author(s):  
Lísia Miglioli-Galvão ◽  
José Osmar Medina Pestana ◽  
Guilherme Lopes-Santoro ◽  
Renato Torres Gonçalves ◽  
Lúcio R. Requião Moura ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Case Control Study ◽  
Strongyloides Stercoralis ◽  
Case Control ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Control Study

scholarly journals Belatacept Rescue Therapy in Kidney Transplant Recipients With Vascular Lesions: A Case Control Study

2017 ◽  
Vol 17 (11) ◽  
pp. 2937-2944 ◽  
Author(s):  
D. Bertrand ◽  
L. Cheddani ◽  
I. Etienne ◽  
A. François ◽  
M. Hanoy ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Case Control Study ◽  
Rescue Therapy ◽  
Case Control ◽  
Vascular Lesions ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Control Study

scholarly journals Sun Habits in Kidney Transplant Recipients with Skin Cancer: A Case-control Study of Possible Causative Factors

2003 ◽  
Vol 83 (3) ◽  
pp. 189-193 ◽  
Author(s):  
Bernt Lindelöf ◽  
Fredrik Granath ◽  
Henrik Dal ◽  
Yvonne Brandberg ◽  
Johanna Adami ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Kidney Transplant ◽  
Case Control Study ◽  
Case Control ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Causative Factors ◽  
Sun Habits ◽  
Control Study
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