Efficacy and safety of uninterrupted low-intensity warfarin for cryoballoon ablation of atrial fibrillation in the elderly: A pilot study

2018 ◽  
Vol 43 (3) ◽  
pp. 401-407 ◽  
Author(s):  
Y. Xing ◽  
B. Xu ◽  
X. Sheng ◽  
C. Xu ◽  
F. Peng ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pilot Study ◽  
The Elderly ◽  
Cryoballoon Ablation ◽  
Efficacy And Safety ◽  
Low Intensity

Efficacy and Safety of Uninterrupted Low-Intensity Warfarin for Radiofrequency Catheter Ablation of Atrial Fibrillation in the Elderly

2017 ◽  
Vol 51 (9) ◽  
pp. 735-742 ◽  
Author(s):  
Yangbo Xing ◽  
Buyun Xu ◽  
Chao Xu ◽  
Fang Peng ◽  
Biao Yang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Radiofrequency Catheter Ablation ◽  
The Elderly ◽  
Minor Bleeding ◽  
Efficacy And Safety ◽  
Thromboembolic Complications ◽  
Bleeding Events ◽  
Low Intensity ◽  
Group A ◽  
Group B

Background: No previous studies exist investigating the optimal intensity of uninterrupted anticoagulation with warfarin during radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) in the elderly. Objective: Evaluate the efficacy and safety of continuous low-intensity warfarin therapy throughout the periprocedural period of RFCA for AF in the elderly. Methods: This is a prospective randomized study. We enrolled AF patients (age ≥ 70 years) who underwent first-time RFCA for AF. Enrolled patients were randomized to group A and group B. The international normalized ratios before ablation were maintained at 1.5 to 2.0 and 2.0 to 2.5 in group A and B, respectively. Primary end points were periprocedural thromboembolic complications and major bleeding. Secondary end points included periprocedural asymptomatic cerebral emboli (ACE) and minor bleeding. Results: A total of 101 patients were enrolled in our study (group A: 52; group B: 49). Baseline characteristics were well balanced between the 2 groups. Only 1 patient suffered from stroke in group B. No major bleeding events occurred in either group. The incidence of new ACE lesions was comparable between the 2 groups (11.5% vs 8.2%, P = 0.82). Minor bleeding occurred in 1 of 52 (1.9%) patients in group A and in 5 of 49 (10.2%) patients in group B ( P = 0.10). Conclusions: Uninterrupted low-intensity warfarin for RFCA of AF might be as effective as standard-intensity warfarin in preventing periprocedural thromboembolic complications and might be associated with fewer bleeding events in the elderly.

scholarly journals Efficacy and Safety of Ablation for Symptomatic Atrial Fibrillation in Elderly Patients: A Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Wei-Chieh Lee ◽  
Po-Jui Wu ◽  
Huang-Chung Chen ◽  
Hsiu-Yu Fang ◽  
Ping-Yen Liu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Elderly Patients ◽  
Meta Analysis ◽  
The Elderly ◽  
Cryoballoon Ablation ◽  
Efficacy And Safety ◽  
Af Ablation ◽  
Fluoroscopic Time ◽  
Procedural Time ◽  
Similar Incidence

Background: Age affects the efficacy of pharmacological treatment for atrial fibrillation (AF). Catheter ablation, including radiofrequency (RF) or cryoballoon ablation, is an effective strategy for symptomatic AF. This meta-analysis aimed to analyze the efficacy and safety of AF ablation in elderly patients with AF compared to non-elderly patients with AF.Methods: We searched several databases for articles published between January 1, 2008 and March 31, 2020. Eighteen observational studies with 21,039 patients were analyzed. Data including recurrence of AF or atrial tachyarrhythmia (ATA), complications, procedural time, and fluoroscopic time were compared between the elderly and non-elderly groups.Results: The elderly patients had significantly higher incidences of recurrent AF or ATA after AF ablation compared to the non-elderly patients (<60 years old) (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.11–1.33). The elderly patients had significantly higher incidences of complications of AF ablation compared to the non-elderly patients (OR, 1.37; 95% CI, 1.14–1.64). However, elderly AF patients with age ≥75 years old had similar incidence of recurrent AF or ATA and complication after AF ablation compared to non-elderly patients with AF.Conclusions: The elderly patients had significantly higher incidences of recurrent AF or ATA and complications after ablation for non-paroxysmal AF compared to non-elderly patients with AF (<60 years old), except in patients ≥75 years old.

Efficacy and safety of cryoballoon ablation for atrial fibrillation: A systematic review of published studies

Heart Rhythm ◽  
2011 ◽  
Vol 8 (9) ◽  
pp. 1444-1451 ◽  
Author(s):  
Jason G. Andrade ◽  
Paul Khairy ◽  
Peter G. Guerra ◽  
Marc W. Deyell ◽  
Lena Rivard ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Systematic Review ◽  
Cryoballoon Ablation ◽  
Efficacy And Safety

Hot balloon versus cryoballoon ablation for persistent atrial fibrillation: Lesion area, efficacy, and safety

2020 ◽  
Vol 31 (9) ◽  
pp. 2310-2318 ◽  
Author(s):  
Yuji Wakamatsu ◽  
Shiro Nakahara ◽  
Koichi Nagashima ◽  
Reiko Fukuda ◽  
Naoki Nishiyama ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Persistent Atrial Fibrillation ◽  
Cryoballoon Ablation ◽  
Efficacy And Safety ◽  
Lesion Area

Intracardiac Echocardiography Improves Procedural Efficiency During Cryoballoon Ablation for Atrial Fibrillation: A Pilot Study

2010 ◽  
Vol 21 (11) ◽  
pp. 1202-1207 ◽  
Author(s):  
MARTIN SCHMIDT ◽  
MARCOS DACCARETT ◽  
HARALD MARSCHANG ◽  
GUIDO RITSCHER ◽  
OLIVER TURSCHNER ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pilot Study ◽  
Intracardiac Echocardiography ◽  
Cryoballoon Ablation
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