Effect of zoledronic acid therapy on postmenopausal osteoporosis between the Uighur and Han population in Xinjiang: An open-label, long-term safety and efficacy study

2017 ◽  
Vol 43 (3) ◽  
pp. 336-341
Author(s):  
W. Xu ◽  
C. Xiang ◽  
H. Wang ◽  
H. Yuan ◽  
X. Zhao ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Postmenopausal Osteoporosis ◽  
Efficacy Study ◽  
Open Label ◽  
Acid Therapy ◽  
Safety And Efficacy ◽  
Han Population

scholarly journals Bone Metastases in Advanced Prostate Cancer

2005 ◽  
Vol 00 (00) ◽  
pp. 1
Author(s):  
Fred Saad ◽  
Keyword(s):  
Prostate Cancer ◽  
Zoledronic Acid ◽  
Bone Metastases ◽  
Advanced Prostate Cancer ◽  
Bone Pain ◽  
Controlled Trial ◽  
Open Label ◽  
Acid Therapy ◽  
Clinically Significant

Men with advanced prostate cancer are at high risk for development of bone metastases,resulting in clinically significant skeletal morbidity and severe bone pain. Studies of early-generation bisphosphonates,clodronate, and pamidronate,demonstrated transient palliative effects on bone pain in patients with bone metastases, but failed to demonstrate long-term clinical benefit.A small,open-label study of ibandronate demonstrated significant reductions in pain,but these results have not been confirmed in a larger,randomized,controlled trial. Currently,zoledronic acid is the only bisphosphonate that has demonstrated statistically significant reductions in skeletal morbidity – including durable pain reduction– in this patient population in a randomized placebocontrolled trial.Therefore,zoledronic acid therapy should be considered to prevent skeletal morbidity and improve the quality of life of prostate cancer patients with bone metastases.

scholarly journals Long‐term safety and efficacy of add‐on cannabidiol in patients with Lennox–Gastaut syndrome: Results of a long‐term open‐label extension trial

Epilepsia ◽  
2021 ◽  
Author(s):  
Anup D. Patel ◽  
Maria Mazurkiewicz‐Bełdzińska ◽  
Richard F. Chin ◽  
Antonio Gil‐Nagel ◽  
Boudewijn Gunning ◽  
...  
Keyword(s):  
Open Label ◽  
Safety And Efficacy ◽  
Open Label Extension ◽  
Extension Trial
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