scholarly journals Polymorphism of PXR gene associated with the increased risk of drug-induced liver injury in Indonesian pulmonary tuberculosis patients

2015 ◽  
Vol 40 (6) ◽  
pp. 680-684 ◽  
Author(s):  
Z. Zazuli ◽  
M. I. Barliana ◽  
U. A. Mulyani ◽  
D. A. Perwitasari ◽  
H. Ng ◽  
...  
Keyword(s):  
Liver Injury ◽  
Pulmonary Tuberculosis ◽  
Drug Induced ◽  
Tuberculosis Patients ◽  
Drug Induced Liver Injury ◽  
Increased Risk

scholarly journals The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Jingwei Zhang ◽  
Zhenzhen Zhao ◽  
Hao Bai ◽  
Lin Jiao ◽  
Qian Wu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Genetic Model ◽  
Joint Effect ◽  
Dependent Manner ◽  
Antituberculosis Drug ◽  
Drug Induced ◽  
Effect Analysis ◽  
Tuberculosis Patients ◽  
Drug Induced Liver Injury ◽  
Increased Risk

Background. TGFBRAP1 and TGFBR2 play important roles in the TGF-β/smad signalling pathway and may disturb liver homeostasis by regulating liver injury and renewal. However, little is known about the association between their genetic polymorphisms and antituberculosis drug-induced liver injury (ATDILI), so we explored the association between their variants and the susceptibility to ATDILI. Materials and Methods. A total of 746 tuberculosis patients were prospectively enrolled, and fifteen selected SNPs were genotyped. The allele, genotype, and genetic model frequencies of the variants were compared between patients with or without ATDILI, as well as the joint effect analysis of SNP-SNP interactions. The odds ratio (OR) with the corresponding 95% confidence interval (CI) was calculated. Results. The A variant at rs17687727 was significantly associated with an increased risk for ATDILI (OR 1.55; 95% CI: 1.08–2.22; p=0.016), which is consistent with the results in the additive and dominant models. Other allele, genotype, and genetic model frequencies were similar in the two groups for the other fourteen SNPs (all p>0.05). Conclusion. Our study first implied that the A variant of rs17687727 in TGFBRAP1 influenced the susceptibility to ATDILI in first-line antituberculosis combination treatment in the Han Chinese population in a dependent manner.

scholarly journals CYP2E1, GSTM1, and GSTT1 genetic polymorphisms and their associations with susceptibility to antituberculosis drug-induced liver injury in Thai tuberculosis patients

Heliyon ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. e06852
Author(s):  
Noppadol Chanhom ◽  
Sukanya Wattanapokayakit ◽  
Nusara Satproedprai ◽  
Supharat Suvichapanich ◽  
Surakameth Mahasirimongkol ◽  
...  
Keyword(s):  
Liver Injury ◽  
Genetic Polymorphisms ◽  
Antituberculosis Drug ◽  
Drug Induced ◽  
Tuberculosis Patients ◽  
Drug Induced Liver Injury

Drugs and liver damage

2010 ◽  
pp. 2527-2537
Author(s):  
J. Neuberger
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Pulmonary Tuberculosis ◽  
Liver Damage ◽  
Case History ◽  
Genetic Component ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Almost All

Case History—A 22 yr old man, being treated for pulmonary tuberculosis, now presenting with confusion and jaundice. Drug-induced liver injury (DILI) is relatively uncommon but can very rarely be fatal. Almost all patterns of liver disease can be induced by drugs, and some drugs may be associated with more than one type of reaction. Some cases of DILI have a genetic component. Most cases present with jaundice and/or hepatitis....

scholarly journals CYP2E1 polymorphism, acetylator profiles and drug-induced liver injury incidence of Indonesian tuberculosis patients

2016 ◽  
Vol 63 (3) ◽  
pp. 139-143 ◽  
Author(s):  
Dyah A. Perwitasari ◽  
Lalu M. Irham ◽  
Endang Darmawan ◽  
Ully A. Mulyani ◽  
J. Atthobari
Keyword(s):  
Liver Injury ◽  
Injury Incidence ◽  
Drug Induced ◽  
Tuberculosis Patients ◽  
Drug Induced Liver Injury
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