scholarly journals Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment

2019 ◽  
Vol 60 (7) ◽  
pp. 752-761 ◽  
Author(s):  
Mattia I. Gerin ◽  
Essi Viding ◽  
Jean‐Baptiste Pingault ◽  
Vanessa B. Puetz ◽  
Annchen R. Knodt ◽  
...  
Keyword(s):  
Childhood Maltreatment ◽  
Internalizing Symptoms ◽  
Stress Generation ◽  
Amygdala Reactivity

Childhood Maltreatment and Anhedonic Symptoms: Test of a Dual-risk Model in Emerging Adults

2020 ◽  
pp. 088626052096924
Author(s):  
Joseph R. Cohen ◽  
Shiesha McNeil ◽  
Suvarna V. Menon
Keyword(s):  
Positive Affect ◽  
Emerging Adults ◽  
Childhood Abuse ◽  
Childhood Maltreatment ◽  
Interpersonal Violence ◽  
Internalizing Symptoms ◽  
Risk Model ◽  
Negative Mood ◽  
Self Report ◽  
Post Traumatic Stress

Anhedonia, defined as deficits in positive affect and approach related behaviors, remains an understudied trauma response. As anhedonic responses to interpersonal violence are associated with a more severe course of psychopathology that is more difficult to treat, an increased focus on risk factors for anhedonia is necessary. The present study sought to address this gap in the literature by testing a theoretical model that highlights two transdiagnostic pathways leading to anhedonic responses in emerging adults attending college. Specifically, our study examined how childhood maltreatment subtypes (a) uniquely associate with depressive and post-traumatic stress (PTS) manifestations of anhedonia and (b) how temperament (i.e., anticipatory positive affect) and distress (i.e., negative mood) explain these relations. At baseline, a racially diverse sample of 462 emerging adults (AgeMean = 19.45; 75.5% female; 45.5% White) completed self-report forms on childhood abuse and neglect, anticipatory positive affect, negative mood, and anhedonia. Individuals completed measures of temperament and psychological distress again 6-weeks, and 12-weeks later. Latent growth curve models were utilized to test our model. Consistent with hypotheses, deficits in anticipatory positive affect uniquely explained the relation between neglect and depressive/PTS anhedonic symptoms. Meanwhile, negative mood mediated the relation between abuse and both forms of anhedonia. These findings support the theory that two separate risk pathways lead to anhedonia. Support for our model suggests that distinguishing between pathways for anhedonic responses may be the key to a more targeted, transdiagnostic, trauma-informed approach for treating and preventing these deleterious, treatment-resistant, internalizing symptoms.

Why Does Frustration Predict Psychopathology? Multiple Prospective Pathways over Adolescence: A Trails Study

2017 ◽  
Vol 31 (1) ◽  
pp. 85-103 ◽  
Author(s):  
Bertus F. Jeronimus ◽  
Harriëtte Riese ◽  
Albertine J. Oldehinkel ◽  
Johan Ormel
Keyword(s):  
Life Stress ◽  
Internalizing Symptoms ◽  
Stressful Life Events ◽  
Stress Sensitivity ◽  
Self Report ◽  
Stress Generation ◽  
Cross Sectional ◽  
Personality Psychology ◽  
Common Causes ◽  
Carry Over

Adolescents’ temperamental frustration is a developmental precursor of adult neuroticism and psychopathology. Because the mechanisms that underlie the prospective association between adolescents’ high frustration and psychopathology (internalizing/externalizing) have not been studied extensively, we quantified three pathways: stress generation [mediation via selection/evocation of stressful life events (SLEs)], cross–sectional frustration–psychopathology overlap (‘carry–over’/common causes), and a direct (non–mediated) vulnerability effect of frustration, including moderation of SLE impact. Frustration and psychopathology were assessed at age 16 with the Early Adolescent Temperament Questionnaire and the Youth Self–Report. No gender differences in frustration were observed. At age 19, psychopathology was reassessed by using the Adult Self–Report, while occurrence of endogenous (self–generated) and exogenous (not self–generated) SLEs during the interval (ages 16–19) were ascertained with the Life Stress Interview, an investigator–based contextual–stressfulness rating procedure (N = 957). Half of the prospective effect of frustration on psychopathology was explained by baseline overlap, including effects of ‘carry–over’ and common causes, about 5% reflected stress generation (a ‘vicious’ cycle with the environment adolescents navigate and shape), and 45% reflected unmediated association: a direct vulnerability effect including stress sensitivity or moderation of SLE impact. After adjustment for their overlap, frustration predicted the development of externalizing but not internalizing symptoms. Copyright © 2016 European Association of Personality Psychology

scholarly journals Corumination, interpersonal stress generation, and internalizing symptoms: Accumulating effects and transactional influences in a multiwave study of adolescents

2010 ◽  
Vol 22 (1) ◽  
pp. 217-235 ◽  
Author(s):  
Benjamin L. Hankin ◽  
Lindsey Stone ◽  
Patricia Ann Wright
Keyword(s):  
Externalizing Problems ◽  
Internalizing Symptoms ◽  
Self Report ◽  
Stress Generation ◽  
Anxious Arousal ◽  
Mediating Role ◽  
Longitudinal Association ◽  
Interpersonal Stressors ◽  
Internalizing And Externalizing

AbstractThis multiwave longitudinal study investigated potential transactional and accumulating influences among corumination, interpersonal stressors, and internalizing symptoms among a sample of early and middle adolescents (N = 350; 6th–10th graders). Youth completed self-report measures of corumination at Times 1, 2, and 4, and negative life events, internalizing symptoms (general depressive, specific anhedonic depressive, anxious arousal, general internalizing), and externalizing problems at all four time points (5 weeks between each assessment across 4 months). Results supported hypotheses. First, baseline corumination predicted prospective trajectories of all forms of internalizing symptoms but not externalizing problems. Second, baseline corumination predicted generation of interpersonal-dependent, but not interpersonal-independent or noninterpersonal stressors. Third, interpersonal-dependent events partially mediated the longitudinal association between baseline corumination and prospective internalizing symptoms. Fourth, a transactional, bidirectional set of associations was supported in that initial internalizing symptoms and stressors predicted later elevations in corumination, and in turn, corumination predicted later symptoms through the mediating role of interpersonal stressors to complete both streams in the transactional chain of influence. Fifth, girls and older adolescents exhibited higher corumination, but neither age nor sex moderated any associations. These findings are discussed within a transactional, developmental cascade model.

scholarly journals Ecological stress, amygdala reactivity, and internalizing symptoms in preadolescence: Is parenting a buffer?

Cortex ◽  
2021 ◽  
Author(s):  
Michael I. Demidenko ◽  
Ka I. Ip ◽  
Dominic P. Kelly ◽  
Kevin Constante ◽  
Leigh G. Goetschius ◽  
...  
Keyword(s):  
Internalizing Symptoms ◽  
Ecological Stress ◽  
Amygdala Reactivity

scholarly journals Ecological stress, amygdala reactivity, and internalizing problems in preadolescence: Is parenting a buffer?

2020 ◽  
Author(s):  
Michael I Demidenko ◽  
Ka I Ip ◽  
Dominic Kelly ◽  
Kevin Constante ◽  
Leigh Goetschius ◽  
...  
Keyword(s):  
Latent Variable ◽  
Internalizing Symptoms ◽  
Parental Acceptance ◽  
Childhood And Adolescence ◽  
Ecological Stress ◽  
Mediating Role ◽  
Amygdala Activity ◽  
One Year ◽  
Amygdala Reactivity

Ecological stress during adolescent development may increase the sensitivity to negative emotional processes that can contribute to the onset and progression of internalizing behaviors during preadolescence. Although a small number of studies have considered the link among the complex relations in ecological stress, amygdala reactivity and internalizing symptoms in childhood and adolescence, these studies have largely been small, cross-sectional, and often do not consider unique roles of parenting or sex. In the current study, we evaluated the interrelations among ecological stress, amygdala functioning, subsequent internalizing symptoms, and the moderating roles of parenting and sex, 9- and 10-year old preadolescents from the Adolescent Brain Cognitive Development study (ABCD). A subset of participants who met a priori quality control criteria for bilateral amygdala during the N-back faces versus places contrast (N = 7,385; Mean Age = 120 months, SD = 7.52; 49.5% Female) were included in the study. A Confirmatory Factor Analysis (CFA) was performed to create a latent variable of ecological stress, and multiple Structural Equation Model (SEM) models were conducted to evaluate the association among baseline ecological stress and internalizing symptoms one year later, the mediating role of amygdala activity, and moderating effects of parental acceptance and sex. The results revealed a significant association among ecological stress and subsequent internalizing symptoms, which was greater in males than females. There was no association between amygdala activity and ecological stress or subsequent internalizing symptoms, and no mediating role of amygdala, or moderating effect of parental acceptance, on the association between ecological stress and internalizing symptoms. An alternative mediation model was tested and revealed that parental acceptance mediated the association between ecological stress and internalizing symptoms, demonstrating lower internalizing symptoms among preadolescents one year later. Given the lack of association in brain function, ecological stress and internalizing symptoms in this registered report, effects from small studies should be reconsidered in larger samples.

scholarly journals Neural processing of infant and adult face emotion and maternal exposure to childhood maltreatment

2019 ◽  
Vol 14 (9) ◽  
pp. 997-1008 ◽  
Author(s):  
Aviva K Olsavsky ◽  
Joel Stoddard ◽  
Andrew Erhart ◽  
Rebekah Tribble ◽  
Pilyoung Kim
Keyword(s):  
Face Processing ◽  
Social Communication ◽  
Childhood Maltreatment ◽  
Superior Temporal Gyrus ◽  
Comparison Task ◽  
Potential Threat ◽  
Negative Valence ◽  
Face Stimuli ◽  
Infant Faces ◽  
Amygdala Reactivity

Abstract Face processing in mothers is linked to mother–infant social communication, which is critical for parenting and in turn for child development. Neuroimaging studies of child maltreatment-exposed (CME) mothers are sparse compared to studies of mothers with postpartum depression, which have suggested blunted amygdala reactivity to infant stimuli. We expected to see a similar pattern in CME mothers. Based on broader studies in trauma-exposed populations, we anticipated increased amygdala reactivity to negative adult face stimuli in a comparison task in CME mothers given heightened evaluation of potential threat. We examined Neuroimaging studies of mothers with childhood maltreatment exposure (CME) (18–37 years old), who performed infant (N = 45) and/or adult (N = 46) face processing tasks. CME mothers exhibited blunted bilateral amygdala reactivity to infant faces. There was no between-group difference in amygdala reactivity to adult faces. In infant and adult face processing tasks regardless of CME, superior temporal gyrus activation was increased for negative-valence stimuli. Our preliminary findings suggest that childhood maltreatment alters maternal processing of infant social cues, a critical skill impacting infant socioemotional development.

scholarly journals Neurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning

2019 ◽  
Vol 24 (4) ◽  
pp. 435-451 ◽  
Author(s):  
Eamon McCrory ◽  
Joseph R. Ogle ◽  
Mattia Indi Gerin ◽  
Essi Viding
Keyword(s):  
Mental Health ◽  
Social Functioning ◽  
Childhood Maltreatment ◽  
Mental Health Problems ◽  
Mental Health Disorder ◽  
Reward Processing ◽  
Stress Generation ◽  
Neural Function ◽  
Health Vulnerability ◽  
Stress Susceptibility

Childhood maltreatment is associated with a lifetime increase in risk of mental health disorder. We propose that such vulnerability may stem in large part from altered patterns of social functioning. Here, we highlight key findings from the psychological and epidemiological literature indicating that early maltreatment experience compromises social functioning and attenuates social support in ways that increase mental health vulnerability. We then review the extant neuroimaging studies of children and adolescents, focusing on three domains implicated in social functioning: threat processing, reward processing, and emotion regulation. We discuss how adaptations in these domains may increase latent vulnerability to mental health problems by impacting on social functioning via increased stress susceptibility as well as increased stress generation. Finally, we explore how computational psychiatry approaches, alongside systematically reported measures of social functioning, can complement studies of neural function in the creation of a mechanistic framework aimed at informing approaches to prevention and intervention.

scholarly journals Linking Childhood Maltreatment With Girls' Internalizing Symptoms: Early Puberty as a Tipping Point

2013 ◽  
Vol 24 (4) ◽  
pp. 689-702 ◽  
Author(s):  
Jane Mendle ◽  
Leslie D. Leve ◽  
Mark Van Ryzin ◽  
Misaki N. Natsuaki
Keyword(s):  
Childhood Maltreatment ◽  
Internalizing Symptoms ◽  
Tipping Point ◽  
Early Puberty
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