Letter to the Editor: Unreported statistics lead to unverifiable results in study of vitamin D supplementation in children with autism spectrum disorder ‐ Comment regarding Saad, K., et al. (2016)

2017 ◽  
Vol 59 (1) ◽  
pp. e1-e1 ◽  
Author(s):  
David Jeffrey Beale
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Vitamin D Supplementation ◽  
Spectrum Disorder ◽  
Letter To The Editor

scholarly journals The Role of Vitamin D Supplementation in Children with Autism Spectrum Disorder: A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 26
Author(s):  
Monia Kittana ◽  
Asma Ahmadani ◽  
Lily Stojanovska ◽  
Amita Attlee
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Vitamin D Supplementation ◽  
Repetitive Behaviors ◽  
Spectrum Disorder ◽  
Cochrane Library ◽  
Children With Asd

Children with autism spectrum disorder (ASD) present with persistent deficits in both social communication and interactions, along with the presence of restricted and repetitive behaviors, resulting in significant impairment in significant areas of functioning. Children with ASD consistently reported significantly lower vitamin D levels than typically developing children. Moreover, vitamin D deficiency was found to be strongly correlated with ASD severity. Theoretically, vitamin D can affect neurodevelopment in children with ASD through its anti-inflammatory properties, stimulating the production of neurotrophins, decreasing the risk of seizures, and regulating glutathione and serotonin levels. A Title/Abstract specific search for publications on Vitamin D supplementation trials up to June 2021 was performed using two databases: PubMed and Cochrane Library. Twelve experimental studies were included in the synthesis of this review. Children with ASD reported a high prevalence of vitamin D deficiency or insufficiency. In general, it was observed that improved vitamin D status significantly reduced the ASD severity, however, this effect was not consistently different between the treatment and control groups. The variations in vitamin D dose protocols and the presence of concurrent interventions might provide an explanation for the variability of results. The age of the child for introducing vitamin D intervention was identified as a possible factor determining the effectiveness of the treatment. Common limitations included a small number of participants and a short duration of follow-ups in the selected studies. Long-term, well-designed randomized controlled trials are warranted to confirm the effect of vitamin D on severity in children with ASD.

Retracted: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder

2016 ◽  
Vol 59 (1) ◽  
pp. 20-29 ◽  
Author(s):  
Khaled Saad ◽  
Ahmed A. Abdel‐Rahman ◽  
Yasser M. Elserogy ◽  
Abdulrahman A. Al‐Atram ◽  
Amira A. El‐Houfey ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Vitamin D Supplementation ◽  
Spectrum Disorder ◽  
Randomized Controlled

scholarly journals Rickets treatment improves more than bone health in toddler with autism spectrum disorder: A brief report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1987002 ◽  
Author(s):  
Leah D Stalnaker ◽  
Priya Prasher ◽  
Susan Flesher
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Case Report ◽  
Effective Treatment ◽  
Vitamin D Deficiency ◽  
Developmental Delay ◽  
Bone Health ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder

Children with autism spectrum disorder have been found to have lower levels of vitamin D than their peers. Our case report supports the hypothesis that vitamin D may be an effective treatment for developmental delay in autism. In addition, we review the literature surrounding vitamin D deficiency as a potential cause of autism spectrum disorder and the role that vitamin D may play in treatment.

Vitamin D Deficiency and Autism Spectrum Disorder

2020 ◽  
Vol 26 (21) ◽  
pp. 2460-2474
Author(s):  
Martina Siracusano ◽  
Assia Riccioni ◽  
Roberta Abate ◽  
Arianna Benvenuto ◽  
Paolo Curatolo ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Autism Spectrum ◽  
Vitamin D Supplementation ◽  
Spectrum Disorder ◽  
Potential Efficacy ◽  
The Central Nervous System ◽  
Core Symptoms

: Vitamin D is a neurosteroid hormone crucially involved in neurodevelopment. Neural cell proliferation, neurotransmission, oxidative stress and immune function represent the main mechanisms mediated by vitamin D in the Central Nervous System. Therefore, its deficiency during pregnancy and early childhood may significantly impact on a developing brain, leading to possible adverse neuropsychological outcomes including Autism Spectrum Disorder (ASD). Significant vitamin D deficiency is described within children affected by ASD and in pregnant mothers whose offspring will later develop ASD, suggesting a possible role of the hormone as a contributing risk factor in the etiopathogenesis of ASD. We reviewed the actual literature on the potential contributing role of prenatal and early postnatal vitamin D deficiency in ASD etiopathogenesis, at both genetic and environmental levels, and the possible effect of vitamin D supplementation in autistic children. Conflicting but promising results emerged on the topic. : Further Randomized Controlled Trials studies carried out during pregnancy and early infancy are necessary for better understanding the possible contribution of vitamin D deficiency in the etiopathogenesis of autism and the potential efficacy of the hormone supplementation in the improvement of ASD core symptoms.

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