scholarly journals The etiology of autistic traits in preschoolers: a population-based twin study

2017 ◽  
Vol 58 (8) ◽  
pp. 893-901 ◽  
Author(s):  
Eveline L. de Zeeuw ◽  
Catharina E.M. van Beijsterveldt ◽  
Rosa A. Hoekstra ◽  
Meike Bartels ◽  
Dorret I. Boomsma
Twin Research ◽  
1999 ◽  
Vol 2 (2) ◽  
pp. 156-168 ◽  
Author(s):  
Brian M D'Onofrio ◽  
Lenn Murrelle ◽  
Lindon J Eaves ◽  
Michael E McCullough ◽  
Jessica L Landis ◽  
...  

AbstractResearch has consistently shown that religiousness is associated with lower levels of alcohol and drug use, but little is known about the nature of adolescent religiousness or the mechanisms through which it influences problem behavior in this age group. This paper presents preliminary results from the Mid-Atlantic School Age Twin Study, a prospective, population-based study of 6–18-year-old twins and their mothers. Factor analysis of a scale developed to characterize adolescent religiousness, the Religious Attitudes and Practices Inventory (RAPI), revealed three factors: theism, religious/spiritual practices, and peer religiousness. Twin correlations and univariate behavior-genetic models for these factors and a measure of belief that drug use is sinful reveal in 357 twin pairs that common environmental factors significantly influence these traits, but a minor influence of genetic factors could not be discounted. Correlations between the multiple factors of adolescent religiousness and substance use, comorbid problem behavior, mood disorders, and selected risk factors for substance involvement are also presented. Structural equation modeling illustrates that specific religious beliefs about the sinfulness of drugs and level of peer religiousness mediate the relationship between theistic beliefs and religious/spiritual practices on substance use. Limitations and future analyses are discussed.


2021 ◽  
pp. 1-10
Author(s):  
Mark J. Taylor ◽  
Angelica Ronald ◽  
Joanna Martin ◽  
Sebastian Lundström ◽  
Georgina M. Hosang ◽  
...  

Abstract Background There is evidence that autism spectrum disorders (ASDs) co-occur with bipolar disorder (BD) relatively frequently. Individuals with BD often report symptoms of mania and hypomania during adolescence, prior to the age of onset for BD. It is unknown whether these symptoms are associated with ASDs. We examined whether diagnoses of ASDs and autistic traits were associated with hypomania in a large, population-based Swedish twin sample. Methods Parental structured interviews assessed autistic traits, and were used to assign screening diagnoses of ASDs, when twins were aged 9 or 12 (N = 13 533 pairs). Parents then completed questionnaires assessing hypomania when the twins were aged 15 and 18 (N = 3852 pairs at age 15, and 3013 pairs at age 18). After investigating the phenotypic associations between these measures, we used the classical twin design to test whether genetic and environmental influences on autistic traits influence variation in adolescent hypomania. Results Autistic traits and ASD diagnoses in childhood were associated with elevated scores on the measures of adolescent hypomania. Twin analyses indicated that 6–9% of the variance in hypomania was explained by genetic influences that were shared with autistic traits in childhood. When repeating these analyses for specific autistic trait domains, we found a stronger association between social interaction difficulties and hypomania than for other autistic trait domains. Conclusions These results indicate a genetic link between autistic traits and hypomania in adolescence. This adds to the growing evidence base of genetic factors associated with ASDs showing links with psychiatric outcomes across childhood and into adulthood.


2011 ◽  
Vol 41 (12) ◽  
pp. 1665-1674 ◽  
Author(s):  
Sara Moruzzi ◽  
Anna Ogliari ◽  
Angelica Ronald ◽  
Francesca Happé ◽  
Marco Battaglia

2009 ◽  
Vol 33 (11) ◽  
pp. 1211-1218 ◽  
Author(s):  
T Leskinen ◽  
S Sipilä ◽  
M Alen ◽  
S Cheng ◽  
K H Pietiläinen ◽  
...  

2018 ◽  
Vol 57 (5) ◽  
pp. 313-320.e6 ◽  
Author(s):  
Iryna Culpin ◽  
Becky Mars ◽  
Rebecca M. Pearson ◽  
Jean Golding ◽  
Jon Heron ◽  
...  

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