scholarly journals Formation and regeneration of a Wnt‐responsive junctional epithelium

2020 ◽  
Vol 47 (12) ◽  
pp. 1476-1484
Author(s):  
Xue Yuan ◽  
Jinlong Chen ◽  
Lauren A. Van Brunt ◽  
Joseph Grauer ◽  
Quanchen Xu ◽  
...  
Keyword(s):  
Junctional Epithelium

scholarly journals Regeneration of the Junctional Epithelium and Connective Tissue after Transplantation of Detergent-Processed Allo-Teeth

2000 ◽  
Vol 23 (12) ◽  
pp. 845-851 ◽  
Author(s):  
M. Inoue ◽  
T. Nakamura ◽  
K. Shigeno ◽  
H. Ueda ◽  
N. Tamura ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Junctional Epithelium

Immunocytochemical study of nerve fibers containing substance P in the junctional epithelium of rats

1996 ◽  
Vol 31 (3) ◽  
pp. 187-194 ◽  
Author(s):  
T. Tanaka ◽  
M. A. Kido ◽  
T. Ibuki ◽  
T. Yamaza ◽  
T. Kondo ◽  
...  
Keyword(s):  
Substance P ◽  
Nerve Fibers ◽  
Junctional Epithelium ◽  
Immunocytochemical Study

Changes in cell phenotype during regeneration of junctional epithelium of human gingiva in vitro

1989 ◽  
Vol 24 (6) ◽  
pp. 370-377 ◽  
Author(s):  
Jukka I. Salonen ◽  
Mikael B. Kautsky ◽  
Beverly A. Dale
Keyword(s):  
Cell Phenotype ◽  
Junctional Epithelium ◽  
Human Gingiva

A cytochemical study of dense granules in the rat junctional epithelium

1989 ◽  
Vol 24 (3) ◽  
pp. 186-191 ◽  
Author(s):  
Masaki Shimono ◽  
Takashi Inoue ◽  
Yoshinobu Hamada ◽  
Yoshihiro Abiko ◽  
Sadamltsu Hsshlmoto
Keyword(s):  
Junctional Epithelium ◽  
Cytochemical Study ◽  
Dense Granules

scholarly journals The Junctional Epithelium Is Maintained by a Stem Cell Population

2020 ◽  
pp. 002203452096012
Author(s):  
X. Yuan ◽  
J. Chen ◽  
J.A. Grauer ◽  
Q. Xu ◽  
L.A. Van Brunt ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Bone Resorption ◽  
Cell Population ◽  
Barrier Function ◽  
The Body ◽  
Stem Cell Population ◽  
Oral Epithelium ◽  
Junctional Epithelium ◽  
Slow Cycling

The most fundamental function of an epithelial tissue is to act as a barrier, regulating interactions between the external environment and the body. This barrier function typically requires a contiguous cell layer but since teeth penetrate the oral epithelium, a modified barrier has evolved, called the junctional epithelium (JE). In health, the JE attaches to the tooth, sealing the inside of the body against oral micro-organisms. Breakdown of the JE barrier results in periodontal ligament (PDL) disintegration, alveolar bone resorption, and ultimately tooth loss. Using lineage tracing and DNA pulse-chase analyses, we identified an anatomical location in the JE that supported both fast- and slow-cycling Wnt-responsive stem cells that contributed to self-renewal of the tissue. Stem cells produced daughter cells with an extraordinarily high rate of turnover that maintained JE integrity for 1.4 y in mice. Blocking cell proliferation via a chemotherapeutic agent 5-fluorouracil (5-Fu) eliminated fast-cycling stem cells, which caused JE degeneration, PDL destruction, and bone resorption. Upon removal of 5-Fu, slow-cycling stem cells regenerated both the structure and barrier function of the JE. Taken together, our studies identified a stem cell population in the JE and have potential clinical implications for prevention and treatment of periodontitis.

scholarly journals Ultrastructural Changes of Single Cilia in the Junctional Epithelium Following Application of Protease.

1993 ◽  
Vol 35 (1) ◽  
pp. 113-121
Author(s):  
Hajime FUSHIMI ◽  
Toshiro KODAMA ◽  
Koji TUTUMI ◽  
Toshiyuki TAMURA ◽  
Toshio HORI ◽  
...  
Keyword(s):  
Ultrastructural Changes ◽  
Junctional Epithelium

Expression of claudin-4 and -7 in porcine gingival junctional epithelium

2009 ◽  
Vol 42 (4) ◽  
pp. 212-215 ◽  
Author(s):  
Masato Saitoh ◽  
Yoshito Kurashige ◽  
Michiko Nishimura ◽  
Mami Yamazaki ◽  
Seiji Igarashi ◽  
...  
Keyword(s):  
Junctional Epithelium

The Effect of Duration and Force of Mechanical Toothbrushing Stimulation on Proliferative Activity of the Junctional Epithelium

2002 ◽  
Vol 73 (10) ◽  
pp. 1149-1152 ◽  
Author(s):  
Takaaki Tomofuji ◽  
Manabu Morita ◽  
Masazumi Horiuchi ◽  
Tomonori Sakamoto ◽  
Daisuke Ekuni ◽  
...  
Keyword(s):  
Proliferative Activity ◽  
Junctional Epithelium
Sign in / Sign up

Export Citation Format

Share Document