scholarly journals Efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. A systematic review and meta-analysis

2019 ◽  
Vol 46 ◽  
pp. 340-356 ◽  
Author(s):  
Cristiano Tomasi ◽  
Erik Regidor ◽  
Alberto Ortiz-Vigón ◽  
Jan Derks
Keyword(s):  
Systematic Review ◽  
Surgical Therapy ◽  
Meta Analysis ◽  
Bone Defects

Surgical therapy vs continued medical therapy for medically refractory chronic rhinosinusitis: a systematic review and meta-analysis

2016 ◽  
Vol 7 (2) ◽  
pp. 119-127 ◽  
Author(s):  
Zara M. Patel ◽  
Andrew Thamboo ◽  
Luke Rudmik ◽  
Jayakar V. Nayak ◽  
Timothy L. Smith ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Rhinosinusitis ◽  
Medical Therapy ◽  
Surgical Therapy ◽  
Meta Analysis

scholarly journals Effectiveness of Laser Application for Periodontal Surgical Therapy: Systematic Review and Meta-Analysis

2015 ◽  
Vol 86 (12) ◽  
pp. 1352-1363 ◽  
Author(s):  
Shabnam Behdin ◽  
Alberto Monje ◽  
Guo-Hao Lin ◽  
Bruce Edwards ◽  
Abdullah Othman ◽  
...  
Keyword(s):  
Systematic Review ◽  
Surgical Therapy ◽  
Meta Analysis ◽  
Laser Application

scholarly journals Effectiveness of mesenchymal stem cell-conditioned medium in bone regeneration in animal and human models: a systematic review and meta-analysis

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Maria Paula Benavides-Castellanos ◽  
Nathaly Garzón-Orjuela ◽  
Itali Linero
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Animal Models ◽  
Conditioned Medium ◽  
Meta Analysis ◽  
Bone Defects ◽  
Favorable Effect ◽  
Human Models ◽  
Regeneration Of Bone

Abstract Background Given the limitations of current therapies for the reconstruction of bone defects, regenerative medicine has arisen as a new therapeutic strategy along with mesenchymal stem cells (MSCs), which, because of their osteogenic potential and immunomodulatory properties, have emerged as a promising alternative for the treatment of bone injuries. In vivo studies have demonstrated that MSCs have a positive effect on regeneration due to their secretion of cytokines and growth factors that, when collected in conditioned medium (MSC-CM) and applied to an injured tissue, can modulate and promote the formation of new tissue. Objective To evaluate the effectiveness of application of conditioned medium derived from mesenchymal stem cells in bone regeneration in animal and human models. Methods We conducted a systematic review with a comprehensive search through February of 2018 using several electronic databases (MEDLINE, EMBASE, SCOPUS, CENTRAL (Ovid), and LILACS), and we also used the “snowballing technique”. Articles that met the inclusion criteria were selected through abstract review and subsequent assessment of the full text. We assessed the risk of bias with the SYRCLE and Cochrane tools, and three meta-analyses were performed. Results We included 21 articles, 19 of which used animal models and 2 of which used human models. In animal models, the application of MSC-CM significantly increased the regeneration of bone defects in comparison with control groups. Human studies reported early mineralization in regenerated bones, and no bone resorption, inflammation, nor local or systemic alterations were observed in any case. The meta-analysis showed an overall favorable effect of the application of MSC-CM. Conclusions The application of MSC-CM to bone defects has a positive and favorable effect on the repair and regeneration of bone tissue, particularly in animal models. It is necessary to perform additional studies to support the application of MSC-CM in clinical practice.

scholarly journals Precision of cone beam CT to assess periodontal bone defects: a systematic review and meta-analysis

2018 ◽  
Vol 47 (2) ◽  
pp. 20170084 ◽  
Author(s):  
Letícia Fernanda Haas ◽  
Glaucia Santos Zimmermann ◽  
G De Luca Canto ◽  
Carlos Flores-Mir ◽  
Márcio Corrêa
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Cone Beam Ct ◽  
Bone Defects ◽  
Cone Beam ◽  
Periodontal Bone Defects

scholarly journals Long-Term Effect of Four Surgical Periodontal Therapies and One Non-Surgical Therapy: A Systematic Review and Meta-Analysis

2015 ◽  
Vol 86 (10) ◽  
pp. 1150-1158 ◽  
Author(s):  
James Mailoa ◽  
Guo-Hao Lin ◽  
Vahid Khoshkam ◽  
Mark MacEachern ◽  
Hsun-Liang Chan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Surgical Therapy ◽  
Meta Analysis ◽  
Term Effect ◽  
Long Term Effect
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