Chronic periodontitis impairs polymorphonuclear leucocyte–endothelium cell interactions and oxidative stress in humans

2018 ◽  
Vol 45 (12) ◽  
pp. 1429-1439 ◽  
Author(s):  
Mayte Martinez‐Herrera ◽  
Sandra López‐Domènech ◽  
Francisco Javier Silvestre ◽  
Javier Silvestre‐Rangil ◽  
Celia Bañuls ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Periodontitis ◽  
Polymorphonuclear Leucocyte ◽  
Cell Interactions ◽  
And Oxidative Stress

Obesity impairs leukocyte-endothelium cell interactions and oxidative stress in humans

2018 ◽  
Vol 48 (8) ◽  
pp. e12985 ◽  
Author(s):  
Sandra López-Domènech ◽  
Celia Bañuls ◽  
Noelia Díaz-Morales ◽  
Irene Escribano-López ◽  
Carlos Morillas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Interactions ◽  
And Oxidative Stress

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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