Randomized, controlled clinical two-centre study using xenogeneic block grafts loaded with recombinant human bone morphogenetic protein-2 or autogenous bone blocks for lateral ridge augmentation

2017 ◽  
Vol 45 (2) ◽  
pp. 265-276 ◽  
Author(s):  
Daniel S. Thoma ◽  
Michael Payer ◽  
Norbert Jakse ◽  
Stefan P. Bienz ◽  
Jürg Hüsler ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 2 ◽  
Autogenous Bone ◽  
Ridge Augmentation ◽  
Randomized Controlled ◽  
Morphogenetic Protein ◽  
Lateral Ridge ◽  
Human Bone Morphogenetic Protein ◽  
Lateral Ridge Augmentation ◽  
Recombinant Human Bone

Ridge Augmentation Following Implantation of Recombinant Human Bone Morphogenetic Protein-2 in the Dog

2000 ◽  
Vol 71 (3) ◽  
pp. 488-496 ◽  
Author(s):  
Eliane Porto Barboza ◽  
Maria Eugênia Leite Duarte ◽  
Luiz Geolás ◽  
Rachel G. Sorensen ◽  
Gerard E. Riedel ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Ridge Augmentation ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Recombinant Human Bone

scholarly journals A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Xinzhu Zhang ◽  
Kun Zhao ◽  
Feng Yuan ◽  
Youlai Yu ◽  
Bin Deng
Keyword(s):  
Bone Morphogenetic Protein ◽  
Interbody Fusion ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Autogenous Bone ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Group A ◽  
Group B ◽  
Recombinant Human Bone

With an increasing elderly population worldwide, the incidence of spine degenerative diseases with neck and shoulder pain as the main symptom is rising obviously, which has now become one of the important and difficult problems in sociomedical science. This study was to explore the effects of different ratios of recombinant human bone morphogenetic protein-2 (rhBMP-2) compound to the autogenous bone on cervical interbody fusion. 90 cervical degeneration patients with the need of surgical treatment admitted to our hospital from January 2019 to January 2020 were selected as the research objects and equally divided into group A, group B, and group C according to the order of admission, with 30 cases in each group and the ratios of rhBMP-2 compound to autogenous bone being 2 : 1, 1 : 1, and 1 : 2 respectively, and standard anterior cervical diskectomy and fusion (ACDF) treatment was performed to all patients to compare their surgery-related indexes, the Japanese Orthopaedic Association (JOA) score, the visual analog scale (VAS) score, the effect of cervical interbody fusion, and the postoperative complication rate (CR). Compared with group A and group C, group B achieved the significantly better surgery-related indexes ( P < 0.05 ), significantly higher postoperative JOA scores ( P < 0.05 ), significantly lower postoperative neck and upper limb VAS scores ( P < 0.05 ), significantly better effect of cervical interbody fusion ( P < 0.05 ), and significantly lower postoperative CR ( P < 0.05 ). 1 : 1 is the best ratio of rhBMP-2 compound to the autogenous bone, for it can optimize patients’ perioperative indexes, reduce the postoperative pain, lower the possibility of complications, and improve the effect of cervical interbody fusion, which should be promoted and applied in practice.

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