scholarly journals Evaluation of DNA methylation of inflammatory genes following treatment of chronic periodontitis: A pilot case-control study

2017 ◽  
Vol 44 (9) ◽  
pp. 905-914 ◽  
Author(s):  
Farah Asa'ad ◽  
Valentina Bollati ◽  
Giorgio Pagni ◽  
Rogerio M. Castilho ◽  
Eleonora Rossi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Chronic Periodontitis ◽  
Case Control Study ◽  
Case Control ◽  
Inflammatory Genes ◽  
Control Study

DEFB4A Promoter Polymorphism Is Associated with Chronic Periodontitis: A Case–Control Study

2020 ◽  
Vol 24 (3) ◽  
pp. 113-119
Author(s):  
Sevda Kurt-Bayrakdar ◽  
Ayla Ozturk ◽  
Esra Tekcan ◽  
Nurten Kara
Keyword(s):  
Chronic Periodontitis ◽  
Case Control Study ◽  
Promoter Polymorphism ◽  
Case Control ◽  
Control Study

DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study

2020 ◽  
Author(s):  
James A Chamberlain ◽  
Pierre-Antoine Dugué ◽  
Julie K. Bassett ◽  
Roger L. Milne ◽  
Jihoon E Joo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Methylation ◽  
Peripheral Blood ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Association of SOCS1−820 (rs33977706) gene polymorphism with chronic periodontitis: A case–control study in Brazilians

Meta Gene ◽  
2015 ◽  
Vol 5 ◽  
pp. 124-128 ◽  
Author(s):  
Roger Antoniaci Guedes ◽  
Aline Cristiane Planello ◽  
Denise Carleto Andia ◽  
Naila F.P. De Oliveira ◽  
Ana Paula de Souza
Keyword(s):  
Gene Polymorphism ◽  
Chronic Periodontitis ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case–control study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Lulu Wang ◽  
Zhenxing Mao ◽  
Xiaotian Liu ◽  
Dandan Wei ◽  
Pengling Liu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Postmenopausal Women ◽  
Case Control Study ◽  
Case Control ◽  
Trial Registration ◽  
Cytokine Signaling ◽  
Combined Effects ◽  
Clinical Trial Registration ◽  
Serum Progesterone ◽  
Control Study

Abstract Background This study aims to investigate the independent and combined effects of progesterone and suppressor of cytokine signaling (SOCS)-3 DNA methylation on type 2 diabetes mellitus (T2DM) among men and postmenopausal women in rural China. Methods A case–control study with 914 participants (329 T2DM, 585 controls) was conducted. Serum progesterone was detected with liquid chromatography-tandem mass spectrometry. DNA methylation of SOCS3 was determined by MethylTarget™. Linear regression was applied to evaluate the associations of progesterone and SOCS3 methylation with marks of glucose metabolism. Logistic regression was employed to investigate the independent and combined effects of progesterone and SOCS3 methylation with T2DM in men and postmenopausal women. Results After multiple adjustment, progesterone was positively associated with T2DM in both men (odds ratio (OR) (95% confidence interval (CI)): 2.77 (1.79, 4.29)) and postmenopausal women (OR (95% CI): 1.85 (1.26, 2.72)). Methylation level of Chr17:76,356,190 or Chr17:76,356,199 (SOCS3) was negatively associated with T2DM in both men (OR (95% CI): 0.58 (0.39, 0.86) or 0.27 (0.14, 0.51)) and postmenopausal women (OR (95% CI): 0.43 (0.29, 0.65) or 0.53 (0.28, 0.99)). Subjects with high progesterone and low Chr17:76,356,190 or Chr17:76,356,199 methylation were more susceptible to have a higher prevalence of T2DM (men: OR (95% CI): 5.20 (2.49, 10.85) or 5.62 (2.74, 11.54); postmenopausal women: OR (95% CI): 3.66 (1.85, 7.26) or 3.27 (1.66, 6.45)). Conclusions The independent and combined effects of progesterone and SOCS3 methylation on T2DM were found among men and postmenopausal women, suggesting that ensuring low levels of progesterone and high methylation of SOCS3 could reduce the prevalence of T2DM. Trial registration The Chinese Clinical Trial registration: The Henan Rural Cohort Study, ChiCTR-OOC-15006699. Registered 06 July 2015, http://www.chictr.org.cn/showproj.aspx?proj=11375

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