scholarly journals Modelling changes in clinical attachment loss to classify periodontal disease progression

2016 ◽  
Vol 43 (5) ◽  
pp. 426-434 ◽  
Author(s):  
Ricardo Teles ◽  
Habtamu K. Benecha ◽  
John S. Preisser ◽  
Kevin Moss ◽  
Jacqueline R. Starr ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Disease Progression ◽  
Clinical Attachment Loss ◽  
Attachment Loss

scholarly journals CD26 Immuno-Expression and Periodontal Disease Progression

2001 ◽  
Vol 1 (2) ◽  
pp. 91-94 ◽  
Author(s):  
P. M. L. Manna ◽  
J. E. Costa ◽  
R. S. Gomez
Keyword(s):  
Periodontal Disease ◽  
Disease Progression ◽  
Cytokine Production ◽  
Membrane Glycoprotein ◽  
Th1 Cell ◽  
Clinical Attachment Loss ◽  
Attachment Loss ◽  
Immunological Mechanisms ◽  
Periodontal Attachment Loss ◽  
Immunohistochemical Identification

Immunological mechanisms participate in the pathogenesis of human chronic inflammatory periodontal disease (CIPD). Human CD4+lymphocytes express functionally heterogeneous profiles of cytokine production. CD26 is an integral membrane glycoprotein, that is, a marker of Th1-like cytokine development. The purpose of the present study was to compare the immuno-expression of CD26 receptor in periodontal sites with and without clinical attachment loss (CAL). Five patients with rapidly progressing periodontitis and one with juvenile periodontitis were investigated. Each patient presented at least one site with and without CAL. Ten sites with CAL and nine without any CAL were biopsied, followed by the immunohistochemical identification of the CD26 receptor using the MIB-DS2/7 antibody. The results demonstrated that the percentage of positive cells for this antigen in the periodontal sites with CAL was not significantly different from those without attachment loss. Therefore, Th1 cell impairment may not be directly involved with periodontal attachment loss.

scholarly journals Patterns of periodontal disease progression based on linear mixed models of clinical attachment loss

2017 ◽  
Vol 45 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Ricardo Teles ◽  
Kevin Moss ◽  
John S. Preisser ◽  
Robert Genco ◽  
William V. Giannobile ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Disease Progression ◽  
Mixed Models ◽  
Linear Mixed Models ◽  
Clinical Attachment Loss ◽  
Attachment Loss

scholarly journals POS0581 PERIODONTAL DISEASE IN RHEUMATOID ARTHRITIS: RESULTS FROM A COHORT AT TREATMENT WITH BIOLOGICAL, CLASSICAL AND TARGETED SYNTHETIC DMARDs

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 524.1-524
Author(s):  
R. Dos-Santos ◽  
F. Otero ◽  
E. Perez-Pampín ◽  
A. Mera Varela
Keyword(s):  
Rheumatoid Arthritis ◽  
Oral Health ◽  
Periodontal Disease ◽  
Disease Activity ◽  
Health Problem ◽  
Multivariable Analysis ◽  
Testing Time ◽  
Univariable Analysis ◽  
Clinical Attachment Loss ◽  
Attachment Loss

Background:Periodontal disease (PD) has been widely studied in the pathogenesis of rheumatoid arthritis (RA). As well, its relationship with severity and disease activity, has also been investigated with ambiguous results. It has been suggested that the improvement of oral health could enhance disease activity scores.1 PD prevalence worldwide stands around 60% in older adults (>65 years) and its frequency increases with aging.2Objectives:To asses oral health in RA patients and to identify predictors of PD in this population.Methods:Patients diagnosed of RA at treatment with biological, classical or targeted synthetic disease modifying anti-rheumatic drugs (b/cs/tsDMARDs) in the aforementioned hospital during 2020 performed a dental review with a specialized periodontal odontologist. Oral health patterns were given for all patients, following criteria of American Academy of Periodontology, and reevaluation of disease activity was made 2 months later.Clinical, demographic and treatment data were collected from participants.Univariable logistic regression was performed to identify predictors of PD. Variables with p<0.20 were selected for multivariable analysis.Stata 15.1 was used to perform statistical analysis.Results:81 patients were recruited. 82.72% were female. Mean age was 56.17 years (SD 14.15) and mean time since diagnosis was 15.58 years (SD 8.17). 25% were current or past smokers. 21 patients had comorbidities (arterial hypertension the most frequent). 66.67% were rheumatoid factor (RF) positive and 72.73% anti-citrullinated peptide autoantibody (ACPA) positive. Median erythrocyte sedimentation rate (ESR) was 12 mm (IQR 6;23) and mean C-reactive protein (CRP) was 0.48 mg/dl (SD 1.18). Mean disease activity score (DAS28-VSG) at the testing time was 2.62 (SD 1.21) and after 2 months was 2.39 (SD 0.97). 96.30% of patients were at treatment with csDMARDs, 64.20% with glucocorticoids, 96.30% with bDMARDs and 6 patients with tsDMARDs.Univariable analysis identified higher age, at least one autoantibody positive and ESR/CRP as potential predictors of medium/severe PD (p<0.20). Multivariable testing including these variables pointed out higher age, lower ESR and at least one autoantibody positive (OR 1.09 [CI95% 1.04-1.14] p=0.001, OR 0.18 [CI95% 0.04-0.95] p=0.044 and OR 0.94 [CI95% 0.88-1.00] p=0.042, respectively) as predictors of medium or severe PD (≥3 mm interdental clinical attachment loss).Univariable analysis identified higher age, the presence of any comorbidity and anti tumour-necrosis factor alpha treatment (anti-TNF) as potential predictors of severe PD (p<0.20). Multivariable testing including these variables pointed out higher age (OR 1.15 [CI95%1.02-1.30] p=0.026) as predictor of severe PD (≥5 mm interdental clinical attachment loss).Conclusion:Periodontal disease is still an extended health problem among the entire population. Its prevalence in RA is increased, therefore higher age and RF or ACPA positive are risk factors for developing severe PD. This analysis might suggest that an aggressive management of PD could implement better responses in DAS28. Also anti-TNF treatment could delimit a “penumbra” group of patients at risk of developing severe PD, where intensive manage could modify the final outcome.References:[1]C O Bingham, M Moni. Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions. Curr Opin Rheumatol. 2013;25(3):345-353.[2]P Carvajal. Periodontal disease as a public health problem: the challenge for primary health care. Rev Clin Periodoncia inplantol. 2016;9(2):177-183.Disclosure of Interests:None declared

Relationship Between Body Mass Index and Chronic Periodontitis

2021 ◽  
Vol 5 (1) ◽  
pp. 7-10
Author(s):  
Shreeya Aryal ◽  
Ameena Pradhan ◽  
Shilu Shrestha ◽  
Surendra Man Shrestha
Keyword(s):  
Body Mass Index ◽  
Periodontal Disease ◽  
Body Mass ◽  
Disease Status ◽  
Periodontal Pocket ◽  
Potential Threat ◽  
Predisposing Factor ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Attachment Loss

Introduction: Obesity is regarded as unnecessary body fat in ratio to lean body mass. Besides being an established risk factor for cardiovascular and other systemic diseases, obesity has been suggested to be a potential threat for periodontitis as well. Objective: The objective of the study was to learn relationship between body mass index (BMI) and periodontal disease. Methods: This analytical cross-sectional study was conducted at People’s Dental College from February 16 to April 15, 2021 after ethical approval. Seventy-two participants were selected conveniently who, on the basis of calculation of weight and height were allocated into two groups: Group A: participants with normal BMI, Group B: Obese/ overweight individuals. Plaque index, gingival index, periodontal pocket, and clinical attachment loss were recorded in both the groups to assess the periodontal disease status. On basis of findings, the two groups were statistically compared. Results: The result showed clinical attachment loss was significantly higher (P <0.001) in overweight/obese group than in normal BMI group (P =0 .001). Conclusion: The findings of this study suggest that obesity and overweight can be a possible predisposing factor for periodontal disease.

Periodontal disease in patients with ankylosing spondylitis

2009 ◽  
Vol 69 (01) ◽  
pp. 34-38 ◽  
Author(s):  
N Pischon ◽  
T Pischon ◽  
E Gülmez ◽  
J Kröger ◽  
P Purucker ◽  
...  
Keyword(s):  
New York ◽  
Ankylosing Spondylitis ◽  
Alcohol Consumption ◽  
Periodontal Disease ◽  
Inflammatory Diseases ◽  
Stepwise Logistic Regression ◽  
Tissue Destruction ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Attachment Loss

Objective:Ankylosing spondylitis (AS) and periodontal disease (PD) are characterised by dysregulation of the host inflammatory response, resulting in soft and hard connective tissue destruction. AS has been related to other inflammatory diseases, however, there is a paucity of data on whether AS is associated with inflammatory PD.Methods:The association between AS and PD was examined in 48 patients with AS and 48 healthy controls, matched for age and gender. AS was diagnosed according to the modified New York criteria. Periodontal examination included probing pocket depth (PPD), clinical attachment loss (CAL), plaque index (PI) and bleeding on probing (BOP). Potential risk factors of PD such as smoking, low education, alcohol consumption, body mass index (BMI), as well as chronic diseases associated with PD and AS were assessed through questionnaires.Results:In stepwise logistic regression, including AS status, age, gender, education, smoking, alcohol consumption and BMI, only AS status, age and education remained significant predictors of PD. Patients with AS had significant 6.81-fold increased odds (95% CI 1.96 to 23.67) of PD (defined as mean attachment loss >3 mm) compared to controls. The strength of the association was attenuated but remained statistically significant after further adjustment for plaque accumulation (odds ratio (OR) 5.48, 95% CI 1.37 to 22.00).Conclusions:The present study shows that patients with AS have a significantly higher risk of PD, strongly suggesting the need for close collaboration between rheumatologists, periodontists and dental hygienists when treating patients with AS.

scholarly journals CORRELATION BETWEEN PERIODONTAL DISEASE INDICES AND LUNG CANCER IN GREEK ADULTS: A CASE — CONTROL STUDY

2016 ◽  
Vol 38 (1) ◽  
pp. 49-53 ◽  
Author(s):  
N A Chrysanthakopoulos
Keyword(s):  
Lung Cancer ◽  
Periodontal Disease ◽  
Case Control Study ◽  
Case Control ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Bleeding On Probing ◽  
Attachment Loss ◽  
Probing Pocket Depth ◽  
Control Study

Aim: The aim of the present case — control study was to examine the possible associations between periodontal disease indices and the risk of lung cancer development in a sample of Greek out-patients referred to a medical and a dental private practice. Materials and Methods: A total of 200 individuals were interviewed and underwent an oral clinical examination, and 64 of them were suffered from several histological types of lung cancer. The estimation of the possible associations between lung cancer as a dependent variable and periodontal disease indices as independent ones was carried out by using a multiple regression analysis model. Results: Probing pocket depth (odds ratio (OR) = 2.72, 95% confidence interval (CI) 1.05–7.06), clinical attachment loss (OR = 3.51, 95% CI 1.30–9.47) bleeding on probing (OR = 1.93, 95% CI 0.98–3.81) were significantly associated with the risk of developing lung cancer. Smoking (OR = 2.49, 95% CI 1.20–5.17) was significantly associated with the mentioned risk, whereas it was consisted as a confounder regarding the estimated associations between moderate/severe clinical attachment loss and presence of bleeding on probing with the risk of developing lung cancer. Conclusion: Probing pocket depth as an index for periodontal disease severity was statistically significantly associated with the risk of developing lung cancer.

scholarly journals Cross-sectional evaluation of clinical parameters to select high prevalence populations for periodontal disease: the site comparative severity methodology

2004 ◽  
Vol 15 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Sérgio Luís Scombatti de Souza ◽  
Mario Taba Jr.
Keyword(s):  
Periodontal Disease ◽  
Age Groups ◽  
Computer Software ◽  
Epidemiological Studies ◽  
Age Group ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Attachment Loss ◽  
Calculated Parameter ◽  
The Subject

Epidemiological studies have shown strong evidence that periodontal disease does not affect all subjects in the same manner. There are subjects and sites with higher risk for disease progression. This study tested parameters to select "a priori" sites and subjects potentially at risk. The data from periodontal clinical examinations of 2273 subjects was used. The clinical loss of attachment was measured in 6 sites per tooth. Using computer software, the patients were distributed into 14 age groups, with intervals of 5 years, from 11 years to greater than 75 years of age. The measure of each site was compared with the average and the median values of the subject age group, with the results indicating site comparative severity (SCS). Three global parameters were calculated: parameter 1 (P1) - percentage of sites with clinical attachment loss > 4 mm; parameter 2 (P2) - percentage of sites with clinical attachment loss > 7 mm; parameter 3 (P3) - percentage of sites with clinical attachment loss surpassing the median value for the age group by 100% or more. There were 1466 (65%) females and 807 (35%) males. Most subjects had P1, P2 and P3 values less than 30%. Parameter 3 allowed a division of the sample similar to that of Parameters 1 and 2, with the advantage of analyzing the subject in relation to his/her age group. It was suggested that the methodology of SCS is useful for selecting a population with a high disease prevalence, and that cut-off lines between 10% and 20% would be appropriate for using Parameter 3.

scholarly journals Comparative Evaluation of Periodontal Status of Chronic Renal Failure Patients and Systemically Healthy Individuals

2018 ◽  
Vol 19 (3) ◽  
pp. 324-330 ◽  
Author(s):  
Radhika Gupta ◽  
Uttam Kumar ◽  
Siddharth Mallapragada ◽  
Pallavi Agarwal
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Periodontal Disease ◽  
Oral Hygiene ◽  
Comparative Evaluation ◽  
Renal Dialysis ◽  
Healthy Individuals ◽  
Clinical Attachment Loss ◽  
Periodontal Status ◽  
Attachment Loss

ABSTRACT Aim Periodontitis, a chronic infectious disease, affects most of the population at one time or the other and its expression is a combination of hosts, microbial agents, and environmental factors. Extensive literature exists for the relationship between periodontal disease and diabetes mellitus, cardiovascular diseases, and adverse pregnancy outcomes. Only a few studies performed in a limited number of patients have reported periodontal health status in chronic renal failure patients. Hence, the aim of the present study is to assess and compare the periodontal status of patients with chronic renal failure undergoing dialysis, predialysis with systemically healthy individuals. Materials and methods A total of 90 patients were divided into three groups. Group I: 30 renal dialysis patients. Group II: 30 predialysis patients. Control group comprised 30 systemically healthy patients who formed group III. Periodontal examination was carried out using oral hygiene index-simplified (OHI-S), plaque index (PI), gingival index (GI), probing depth, and clinical attachment loss. Results The results of the study showed that the periodontal status of patients with chronic renal failure undergoing dialysis (dialysis group) and patients with chronic renal failure not undergoing renal dialysis (predialysis) when compared with systemically healthy subjects showed significantly higher mean scores of OHI-S, PI, and clinical attachment loss. Conclusion Thus, patients with chronic renal failure showed poor oral hygiene and higher prevalence of periodontal disease. Clinical significance The dental community’s awareness of implications of poor health within chronic renal failure patients should be elevated. How to cite this article Gupta R, Kumar U, Mallapragada S, Agarwal P. Comparative Evaluation of Periodontal Status of Chronic Renal Failure Patients and Systemically Healthy Individuals. J Contemp Dent Pract 2018;19(3):324-330.

scholarly journals Food Insecurity and Periodontal Disease in Low-Income Women (P04-043-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Jeanne Freeland-Graves ◽  
Mahsa Babaei ◽  
Prageet Sachdev
Keyword(s):  
Food Security ◽  
Periodontal Disease ◽  
Food Insecurity ◽  
Low Income ◽  
Household Food Security ◽  
P Value ◽  
Clinical Attachment Loss ◽  
Bleeding On Probing ◽  
Attachment Loss ◽  
Household Food

Abstract Objectives To examine the relationships between food security and prevalence and severity of periodontal disease in low-income women. Methods This cross-sectional study involved 220 women, 18–50 years of age, who were recruited from dental clinics and low-income households in Central Texas. On one visit, women completed a Demographic Survey and the United States Household Food Security Survey Module. Two trained dentists conducted dental screenings for evaluation of periodontal status, using two indices: Clinical Attachment Loss (CAL) and Bleeding on Probing (BOP) to discern severity of periodontitis. Multiple regression analysis was used to assess the effect of food insecurity on the status of periodontal disease, after adjustment for socioeconomic status. Results The mean age of participants was 38.13 ± 9.43 years. The majority were Hispanic, had completed a high school education, and had a mean income of <$25,000/year. Over half of the sample (54.55%) was food insecure, followed by marginally food secure (24.09%) and highly food secure (21.36%), based on cut off values of the Household Food Security Survey Module. Mean values for Clinical Attachment Loss and Bleeding on Probing were 1.742 ± 0.75 and 1.632 ± 2.23 respectively. These results indicated that the women exhibited periodontal disease, with stages of mild (56.83%), moderate (26.36%) and severe periodontitis (16.81%). Food insecurity was directly related to the severity of periodontal disease, as illustrated by the Clinical Attachment Loss (β-coefficient = 0.170, p value = 0.01) and Bleeding on Probing (β coefficient = 0.380, p value = 0.00), after adjustment for socioeconomic status. Conclusions Food insecure individuals appear to be at a great risk for periodontal disease. Whether this relationship is due to lack of food resources, improper dental equipment or hygiene, or nutrition knowledge will be explored as the study progresses. This health risk for periodontal disease should be incorporated into public health policies concerning food insecurity. Funding Sources Bess Heflin Centennial Professorship.

Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?

2017 ◽  
Vol 68 (7) ◽  
pp. 1660-1664
Author(s):  
Cristina Iordache ◽  
Rodica Chirieac ◽  
Eugen Ancuta ◽  
Cristina Pomirleanu ◽  
Codrina Ancuta
Keyword(s):  
Ankylosing Spondylitis ◽  
Periodontal Disease ◽  
Systemic Inflammation ◽  
Periodontal Pocket ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Attachment Loss ◽  
Inflammatory Parameters ◽  
Periodontal Inflammation ◽  
The Impact

Although the relation between periodontitis (PD) and systemic disorders (e.g. cardiovascular diseases, diabetes and rheumatoid arthritis) is widely accepted, the association with ankylosing spondylitis (AS) is inconsistently mentioned. We prospectively examined the relationship between periodontal disease and AS, focusing on the rate and course of PD, factors associated with severity and the impact of anti-TNF-a treatment on inflammatory status. Standard assessments performed twice (week 0, week 24) included an extensive dental evaluation (plaque index, gingival index, bleeding on probing, periodontal pocket depth, clinical attachment loss), inflammatory parameters and AS activity scores (BASDAI, ASDAS-CRP). More than half of AS presented with impaired periodontal health at baseline (mild to moderate PD) meaning increased sites with dental plaque, abnormal bleeding, increased periodontal pocket depth and clinical attachment loss. Significant positive correlation between presence and severity of PD, AS activity and systemic inflammation (CRP) was reported at baseline (p[0.05). A final analysis performed at 24 weeks revealed significant improvement in periodontal status, inflammatory parameters and AS activity, suggesting efficacy of TNF inhibitors directed not only against systemic, but also on local (articular, periodontal) inflammation (p[0.05). Patients with AS are at risk to develop periodontal disease, particularly those with high levels of systemic inflammation. Benefits of anti-TNFa therapy in the particular settings of AS patient and concomitant periodontal disease should be validated through further studies in larger cohorts.

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