Serum vitamin B12 is inversely associated with periodontal progression and risk of tooth loss: a prospective cohort study

2016 ◽  
Vol 43 (1) ◽  
pp. 2-9 ◽  
Author(s):  
Geng Zong ◽  
Birte Holtfreter ◽  
Ann E. Scott ◽  
Henry Völzke ◽  
Astrid Petersmann ◽  
...  
Keyword(s):  
Cohort Study ◽  
Vitamin B12 ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Tooth Loss ◽  
Serum Vitamin

scholarly journals Association between serum vitamin B12 and risk of all-cause mortality in elderly adults: a prospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kangjun Xu ◽  
Xiyu Liu ◽  
Jiaxin Liu ◽  
Yingying Zhang ◽  
Xiaohui Ding ◽  
...  
Keyword(s):  
Cohort Study ◽  
Vitamin B12 ◽  
Prospective Cohort Study ◽  
Dose Response ◽  
Prospective Cohort ◽  
Serum Vitamin ◽  
Elderly Adults ◽  
High Concentration ◽  
Increased Risk ◽  
All Cause Mortality

Abstract Background and purpose Results from previous studies that linking vitamin B12 to risk of chronic diseases or mortality are inconsistent. We hereby explore the association between serum concentration of vitamin B12 and all-cause mortality risk in elderly adults. Methods Participants aged over 65 years in the Chinese Longitudinal Healthy Longevity Survey were included in present prospective cohort study. Serum vitamin B12 was assessed at the 2011–2012 and 2014 wave, respectively. Participants were divided into three groups based on two cut-off points − 10th and 90th percentiles of vitamin B12 concentrations - in the whole population. Cox regression model was used to calculate the hazard ratio (HR) and 95 % confidence intervals (95 % CIs), and restricted cubic spline function was further modelled to investigate their dose-response associations. Results Among 2,086 participants [mean ± SD: 87.74 ± 11.24 years, 908 (43.53 %) males], 943 (45.21 %) died during an average follow-up of 3.34 (SD: 1.63) years. Comparing with participants with middle concentration of serum vitamin B12, participants with high concentration had an increased risk of all-cause mortality [HR (95 %CIs): 1.30 (1.03–1.64)], whereas participants with low concentration had an insignificantly decreased risk of all-cause mortality (0.96, 0.76–1.20). The positive association between high concentration of serum vitamin B12 and all-cause mortality was also observed among the male and in a series of sensitivity analyses. In the dose-response analysis, a J-shape pattern was observed, but the non-linear association was only significant in males (Pnon−linearity = 0.0351). Conclusions High concentration of serum vitamin B12 was associated with an increased risk of all-cause mortality in a J-shaped pattern. The precise mechanisms underlying the association remain to be explored.

scholarly journals Serum vitamin D levels and survival of patients with colorectal cancer: Post-hoc analysis of a prospective cohort study

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Hidetoshi Mezawa ◽  
Tsutomu Sugiura ◽  
Michiaki Watanabe ◽  
Chihiro Norizoe ◽  
Daisuke Takahashi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Serum Vitamin ◽  
Post Hoc Analysis ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Post Hoc

scholarly journals Tooth Loss and Decline in Functional Capacity: A Prospective Cohort Study from the Japan Gerontological Evaluation Study

2016 ◽  
Vol 64 (11) ◽  
pp. 2336-2342 ◽  
Author(s):  
Yukihiro Sato ◽  
Jun Aida ◽  
Katsunori Kondo ◽  
Toru Tsuboya ◽  
Richard G. Watt ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Functional Capacity ◽  
Prospective Cohort ◽  
Tooth Loss ◽  
Evaluation Study

scholarly journals Serum Vitamin D in Patients with Chronic Obstructive Lung Disease Does Not Correlate with Mortality – Results from a 10-Year Prospective Cohort Study

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53670 ◽  
Author(s):  
Dennis Back Holmgaard ◽  
Lone Hagens Mygind ◽  
Ingrid Louise Titlestad ◽  
Hanne Madsen ◽  
Palle Bach Nielsen Fruekilde ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Lung Disease ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Obstructive Lung Disease ◽  
Serum Vitamin ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Serum Vitamin D

scholarly journals Micronutrient levels and their effects on the prognosis of visceral leishmaniasis treatment, a prospective cohort study.

2020 ◽  
Author(s):  
berhanu elfu feleke ◽  
Teferi Elfu Feleke
Keyword(s):  
Cohort Study ◽  
Visceral Leishmaniasis ◽  
Family Size ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Treatment Success ◽  
Serum Vitamin ◽  
Iron Level ◽  
Serum Selenium ◽  
Visceral Leishmaniasis Patient

Abstract Background: Micronutrients are minerals and vitamins and they are essential for normal physiological activities. The objectives of the study were to describe the progress and determinants of micronutrient levels and to assess the effects of micronutrients in the treatment outcome of kalazar.Methods: A prospective cohort study design was used. The data were collected using patient interviews, measuring anthropometric indicators, and collecting laboratory samples. The blood samples were collected at five different periods during the leishmaniasis treatments: before starting anti-leishmaniasis treatments, in the first week, in the second week, in the third week, and in the 4th week of anti-leishmaniasis treatments. Descriptive statistics were used to describe the profile of patients and to compare the treatment success rate. The generalized estimating equation was used to identify the determinants of serum micronutrients.Results: The mean age of the patients were 32.88 years [SD (standard deviation) ±15.95]. Male constitute 62.3 % of the patients and problematic alcohol use was present in 11.5 % of the patients. The serum zinc level of visceral leishmaniasis patients was affected by alcohol (B -2.7 [95 % CI: -4.01 - -1.5]), DDS (B 9.75 [95 % CI: 7.71 – 11.79]), family size (B -1.63 [95 % CI: -2.68 - -0.58]), HIV (B -2.95 [95 % CI: -4.97 - -0.92]), and sex (B -1.28 [95 % CI: -2.5 - -0.07]). The serum iron level of visceral leishmaniasis patients was affected by alcohol (B 7.6 [95 % CI: 5.86 – 9.35]), family size (B -5.14 [95 % CI: -7.01 - -3.28]), malaria (B -12.69 [95 % CI: -14.53 - -10.87]), Hookworm (-4.48 [-6.82 - -2.14]), chronic diseases (B -7.44 [95 % CI: -9.75 - -5.13]), and HIV (B -5.51 [95% CI: -8.23 - -2.78]). The serum selenium level of visceral leishmaniasis patient was affected by HIV (B -18.1 [95 % CI: -20.63 - -15.58]) and family size (B -11.36 [95 % CI: -13.02 - -9.7]). The iodine level of visceral leishmaniasis patient was affected by HIV (B -38.02 [95 % CI: -41.98 - -34.06]), DDS (B 25 .84 [95 % CI: 22.57 – 29.1]), smoking (B -12.34 [95 % CI: -15.98 - -8.7]), chronic illness (B -5.14 [95 % CI: -7.82 - -2.46]), and regular physical exercise (B 5.82 [95 % CI: 0.39 - 11.26]). The serum vitamin D level of visceral leishmaniasis patient was affected by HIV (B -9.43 [95 % CI: -10.92 - -7.94]), DDS (B 16.24 [95% CI: 14.89 – 17.58]), malaria (B -0.61 [95 % CI: -3.37 - -3.37]), and family size (B -1.15 [95 % CI: -2.03 - -0.28]). The serum vitamin A level of visceral leishmaniasis patient was affected by residence (B 0.81 [95 % CI: 0.08 - 1.54]), BMI (B 1.52 [95 % CI: 0.42 – 2.6]), DDS (B 1.62 [95 % CI: 0.36 – 2.88]), family size (B -5.03 [95 % CI: -5.83 - -4.22]), HIV (B -2.89 [95% CI: -4.44 - -1.34]),MUAC (B 0.86 [95 % CI: 0.52 – 1.21]), and age (B 0.09 [95 % CI: 0.07 – 0.12]).Conclusion: The micronutrient levels of visceral leishmaniasis patients were significantly lower. The anti-leishmaniasis treatment did not increase the serum micronutrient level of the patients.

Vitamin D status and incidence of tuberculosis infection conversion in contacts of pulmonary tuberculosis patients: a prospective cohort study

2014 ◽  
Vol 143 (8) ◽  
pp. 1731-1741 ◽  
Author(s):  
A. ARNEDO-PENA ◽  
J. V. JUAN-CERDÁN ◽  
M. A. ROMEU-GARCÍA ◽  
D. GARCÍA-FERRER ◽  
R. HOLGUÍN-GÓMEZ ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Protective Factor ◽  
Serum Vitamin ◽  
Interferon Gamma Release Assay ◽  
High Exposure ◽  
Serum Vitamin D ◽  
Latent Tb Infection

SUMMARYThe objective of this study was to estimate the relationship between serum vitamin D (VitD) status and tuberculosis (TB) infection conversion (TBIC), measured by the tuberculin skin test (TST) and an interferon-gamma release assay, the QuantiFERON-TB Gold In-Tube (QFT-GIT) test, in the contacts of pulmonary TB patients in Castellon (Spain) in a prospective cohort study from 2010 to 2012. Initially, the participants were negative to latent TB infection after a screening that included TST and QFT-GIT tests, and other examinations. A baseline determination of 25-hydroxyvitamin D [25(OH)D] was obtained by chemiluminescence immunoassay. After 8–10 weeks, participants were screened for a second time to determine TB infection conversion (TBIC). Poisson regression models were used in the statistical analysis. Of the 247 participants in the cohort, 198 (80·2%) were screened twice and 18 (9·1%) were TBIC cases. The means of VitD concentration in the TBIC cases and the non-cases were 20·7±11·9 and 27·2±11·4 ng/ml (P = 0·028), respectively. Adjusted for high exposure and TB sputum acid-fast bacilli (AFB)-positive index case, higher serum VitD concentration was associated with low incidence of TBIC (Ptrend = 0·005), and an increase of 1 ng/ml VitD concentration decreased the incidence of TBIC by 6% (relative risk 0·94, 95% confidence interval 0·90–0·99, P = 0·015). The results suggest that sufficient VitD level could be a protective factor of TBIC.

Low Vitamin B12 Levels in Early Pregnancy Are Associated with Fasting Glycemia—A Prospective Cohort Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 171-LB
Author(s):  
NITHYA SUKUMAR ◽  
ADAIKALA ANTONYSUNIL ◽  
YONAS GHEBREMICHAEL-WELDESELASS ◽  
ILONA GOLJAN ◽  
CHRISTOS BAGIAS ◽  
...  
Keyword(s):  
Cohort Study ◽  
Vitamin B12 ◽  
Prospective Cohort Study ◽  
Early Pregnancy ◽  
Prospective Cohort ◽  
Fasting Glycemia
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