scholarly journals The effects of providing periodontal disease risk information on psychological outcomes - a randomized controlled trial

2015 ◽  
Vol 42 (4) ◽  
pp. 350-355 ◽  
Author(s):  
Koula Asimakopoulou ◽  
Jonathon Tim Newton ◽  
Blánaid Daly ◽  
Yvonne Kutzer ◽  
Mark Ide
Keyword(s):  
Randomized Controlled Trial ◽  
Periodontal Disease ◽  
Disease Risk ◽  
Controlled Trial ◽  
Risk Information ◽  
Psychological Outcomes ◽  
Randomized Controlled

scholarly journals Impact of personal genomic risk information on melanoma prevention behaviors and psychological outcomes: a randomized controlled trial

2021 ◽  
Author(s):  
Amelia K. Smit ◽  
Martin Allen ◽  
Brooke Beswick ◽  
Phyllis Butow ◽  
Hugh Dawkins ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Risk Information ◽  
Psychological Outcomes ◽  
Skin Cancer Prevention ◽  
European Ancestry ◽  
Polygenic Risk Score ◽  
Randomized Controlled ◽  
The Impact ◽  
Genomic Risk

Abstract Purpose We evaluated the impact of personal melanoma genomic risk information on sun-related behaviors and psychological outcomes. Methods In this parallel group, open, randomized controlled trial, 1,025 Australians of European ancestry without melanoma and aged 18–69 years were recruited via the Medicare database (3% consent). Participants were randomized to the intervention (n = 513; saliva sample for genetic testing, personalized melanoma risk booklet based on a 40-variant polygenic risk score, telephone-based genetic counseling, educational booklet) or control (n = 512; educational booklet). Wrist-worn ultraviolet (UV) radiation dosimeters (10-day wear) and questionnaires were administered at baseline, 1 month postintervention, and 12 months postbaseline. Results At 12 months, 948 (92%) participants completed dosimetry and 973 (95%) the questionnaire. For the primary outcome, there was no effect of the genomic risk intervention on objectively measured UV exposure at 12 months, irrespective of traditional risk factors. For secondary outcomes at 12 months, the intervention reduced sunburns (risk ratio: 0.72, 95% confidence interval: 0.54–0.96), and increased skin examinations among women. Melanoma-related worry was reduced. There was no overall impact on general psychological distress. Conclusion Personalized genomic risk information did not influence sun exposure patterns but did improve some skin cancer prevention and early detection behaviors, suggesting it may be useful for precision prevention. There was no evidence of psychological harm.

scholarly journals Using web-based familial risk information for diabetes prevention: a randomized controlled trial

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Miranda Wijdenes ◽  
Lidewij Henneman ◽  
Nadeem Qureshi ◽  
Piet J Kostense ◽  
Martina C Cornel ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Diabetes Prevention ◽  
Controlled Trial ◽  
Familial Risk ◽  
Risk Information ◽  
Web Based ◽  
Randomized Controlled

scholarly journals Randomized Controlled Trial to Assess Reduction of Cardiovascular Disease Risk in Patients With Bipolar Disorder

2013 ◽  
Vol 74 (07) ◽  
pp. e655-e662 ◽  
Author(s):  
Amy M. Kilbourne ◽  
David E. Goodrich ◽  
Zongshan Lai ◽  
Edward P. Post ◽  
Karen Schumacher ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Bipolar Disorder ◽  
Randomized Controlled Trial ◽  
Disease Risk ◽  
Controlled Trial ◽  
Cardiovascular Disease Risk ◽  
Randomized Controlled
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