Influence of intra-pocket anesthesia gel on treatment outcome in periodontal patients: a randomized controlled trial

2014 ◽  
Vol 41 (5) ◽  
pp. 481-488 ◽  
Author(s):  
Sonja H. M. Derman ◽  
Claudia E. Lowden ◽  
Martin Hellmich ◽  
Michael J. Noack
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Outcome ◽  
Controlled Trial ◽  
Randomized Controlled

The effect of feedback-informed cognitive behavioral therapy on treatment outcome: A randomized controlled trial.

2020 ◽  
Vol 88 (9) ◽  
pp. 818-828
Author(s):  
Pauline D. Janse ◽  
Kim de Jong ◽  
Carola Veerkamp ◽  
Maarten K. van Dijk ◽  
Giel J. M. Hutschemaekers ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Outcome ◽  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Controlled Trial ◽  
Cognitive Behavioral ◽  
Randomized Controlled

Impaired Insight Into Delusions Predicts Treatment Outcome During a Randomized Controlled Trial for Psychotic Depression (STOP-PD Study)

2015 ◽  
Vol 76 (04) ◽  
pp. 427-433 ◽  
Author(s):  
Philip Gerretsen ◽  
Alastair J. Flint ◽  
Ellen M. Whyte ◽  
Anthony J. Rothschild ◽  
Barnett S. Meyers ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Outcome ◽  
Controlled Trial ◽  
Psychotic Depression ◽  
Randomized Controlled ◽  
Insight Into

scholarly journals Improving Treatment Outcome in Children With Obesity by an Online Self-Control Training: A Randomized Controlled Trial

2021 ◽  
Vol 9 ◽  
Author(s):  
Eline Vermeiren ◽  
Tiffany Naets ◽  
Annelies Van Eyck ◽  
Leentje Vervoort ◽  
Marijke Ysebaert ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Outcome ◽  
Controlled Trial ◽  
Obesity Treatment ◽  
Self Control ◽  
Long Term Results ◽  
Treatment Programs ◽  
Randomized Controlled ◽  
Present Trial

Background: Currently available treatment programs for children with obesity only have modest long-term results, which is (at least partially) due to the poorer self-control observed within this population. The present trial aimed to determine whether an online self-control training, training inhibition, and redirecting attentional bias, can improve the short- and long-term treatment outcome of (in- or outpatient) child obesity treatment programs.Methods: In this double-blind multi-center randomized controlled trial (RCT), participants aged 8–18 years with obesity were allocated in a 1:1 ratio to receive an online self-control or sham training added to their in- or outpatient multidisciplinary obesity treatment (MOT) program. The primary endpoint was BMI SDS. Data were analyzed by linear mixed models and the main interactions of interest were randomization by time and randomization by number of sessions, as the latter was cumulatively expressed and therefore represents the effect of increasing dose over time.Results: One hundred forty-four inpatient (mean age 14.3 ± 2.2 years, BMI 2.7 ± 0.4 SDS, 42% male) and 115 outpatient children (mean age 11.9 ± 2.1 years, BMI 2.4 ± 0.4 SDS, 45% male) were included. Children's BMI lowered significantly during treatment in both the in- and outpatient treatment centers, p < 0.001. In a mixed model with BMI as dependent variable, randomization by time was non-significant, but the number of self-control trainings (randomization * number of sessions) interacted significantly with setting and with age (p = 0.002 and p = 0.047), indicating a potential effect in younger inpatient residents. Indeed, a subgroup analysis on 22 inpatient children of 8–12 years found a benefit of the number of self-control trainings on BMI (p = 0.026).Conclusions: The present trial found no benefit of the self-control training in the entire study population, however a subgroup of young, inpatient participants potentially benefited.

Treatment outcome in patients with clinically defined carpal tunnel syndrome but normal electrodiagnostic test results: a randomized controlled trial

2017 ◽  
Vol 264 (12) ◽  
pp. 2394-2400 ◽  
Author(s):  
Floriaan G. C. M. De Kleermaeker ◽  
Jan Meulstee ◽  
Franka Claes ◽  
Kristel M. Kasius ◽  
Wim I. M. Verhagen
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Outcome ◽  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Controlled Trial ◽  
Test Results ◽  
Randomized Controlled ◽  
Tunnel Syndrome

scholarly journals Clinical Efficacy and Cost-Effectiveness of Imagery Rescripting Only Compared to Imagery Rescripting and Schema Therapy in Adult Patients With PTSD and Comorbid Cluster C Personality Disorder: Study Design of a Randomized Controlled Trial

2021 ◽  
Vol 12 ◽  
Author(s):  
Arne van den End ◽  
Jack Dekker ◽  
Aartjan T. F. Beekman ◽  
Inga Aarts ◽  
Aishah Snoek ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Treatment Outcome ◽  
Cost Effectiveness ◽  
Personality Disorder ◽  
Clinical Efficacy ◽  
Controlled Trial ◽  
Schema Therapy ◽  
Evidence Based ◽  
Randomized Controlled ◽  
Imagery Rescripting

Background: Posttraumatic stress disorder (PTSD) is a serious and relatively common mental disorder causing a high burden of suffering. Whereas evidence-based treatments are available, dropout and non-response rates remain high. PTSD and Cluster C personality disorders (avoidant, dependent or obsessive-compulsive personality disorder; CPD) are highly comorbid and there is evidence for suboptimal treatment effects in this subgroup of patients. An integrated PTSD and CPD treatment may be needed to increase treatment efficacy. However, no studies directly comparing the efficacy of regular PTSD treatment and treatment tailored to PTSD and comorbid CPD are available. Whether integrated treatment is more effective than treatment focused on PTSD alone is important, since (1) no evidence-based guideline for PTSD and comorbid CPD treatment exists, and (2) treatment approaches to CPD are costly and time consuming. Present study design describes a randomized controlled trial (RCT) directly comparing trauma focused treatment with integrated trauma focused and personality focused treatment.Methods: An RCT with two parallel groups design will be used to compare the clinical efficacy and cost-effectiveness of “standalone” imagery rescripting (n = 63) with integrated imagery rescripting and schema therapy (n = 63). This trial is part of a larger research project on PTSD and personality disorders. Predictors, mediators and outcome variables are measured at regular intervals over the course of 18 months. The main outcome is PTSD severity at 12 months. Additionally, machine-learning techniques will be used to predict treatment outcome using biopsychosocial variables.Discussion: This study protocol outlines the first RCT aimed at directly comparing the clinical efficacy and cost-effectiveness of imagery rescripting and integrated imagery rescripting and schema therapy for treatment seeking adult patients with PTSD and comorbid cluster C personality pathology. Additionally, biopsychosocial variables will be used to predict treatment outcome. As such, the trial adds to the development of an empirically informed and individualized treatment indication process.Clinical Trial registration:ClinicalTrials.gov, NCT03833531.

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