scholarly journals Chronic exposure to biomass ambient particulate matter triggers alveolar macrophage polarization and activation in the rat lung

2022 ◽  
Author(s):  
Shenlin Wang ◽  
Yuhua Chen ◽  
Wei Hong ◽  
Bing Li ◽  
Yumin Zhou ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Alveolar Macrophage ◽  
Chronic Exposure ◽  
Macrophage Polarization ◽  
Rat Lung ◽  
Ambient Particulate Matter

scholarly journals Chronic exposure to ambient particulate matter induces gut microbial dysbiosis in a rat COPD model

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Naijian Li ◽  
Zhaowei Yang ◽  
Baoling Liao ◽  
Tianhui Pan ◽  
Jinding Pu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Chronic Exposure ◽  
Pulmonary Inflammation ◽  
Short Chain Fatty Acids ◽  
Chronic Obstructive ◽  
Rat Lung ◽  
Ambient Particulate Matter ◽  
Microbial Composition ◽  
Obstructive Pulmonary Disease ◽  
Microbial Dysbiosis

Abstract Background The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown. Methods Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24 weeks. We performed pulmonary inflammation evaluation, morphometric measurements, and lung function analysis in rat lung at three different times points during exposure. Lung and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified. Results After a 24-week PM exposure, rats exhibited pulmonary inflammation and pathological changes characteristic of COPD. The control and PM exposure (BMF and MVE) groups showed similar microbial diversity and composition in rat lung. However, the gut microbiota after 24 weeks PM exposure was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide. Conclusion Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.

scholarly journals Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

2020 ◽  
Author(s):  
Naijian Li ◽  
Zhaowei Yang ◽  
Baoling Liao ◽  
Tianhui Pan ◽  
Jinding Pu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Chronic Exposure ◽  
Pulmonary Inflammation ◽  
Short Chain Fatty Acids ◽  
Chronic Obstructive ◽  
Rat Lung ◽  
Ambient Particulate Matter ◽  
Microbial Composition ◽  
Obstructive Pulmonary Disease ◽  
Microbial Dysbiosis

Abstract Background: The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown.Methods: Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24 weeks. We performed pulmonary inflammation evaluation, morphometric measurements, and lung function analysis in rat lung at three different times points during exposure. Lung and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified.Results: After a 24-week PM exposure, rats exhibited pulmonary inflammation and pathological changes characteristic of COPD. The control and PM exposure (BMF and MVE) groups showed similar microbial diversity and composition in rat lung. However, the gut microbiota after 24 weeks PM exposure was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide.Conclusion: Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.

scholarly journals Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

2020 ◽  
Author(s):  
Naijian Li ◽  
Zhaowei Yang ◽  
Baoling Liao ◽  
Tianhui Pan ◽  
Jinding Pu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Particulate Matter ◽  
Pulmonary Disease ◽  
Chronic Exposure ◽  
Short Chain Fatty Acids ◽  
Chronic Obstructive ◽  
Ambient Particulate Matter ◽  
Microbial Composition ◽  
Obstructive Pulmonary Disease ◽  
Microbial Dysbiosis

Abstract Background: The role of the gut microbiota in the pathogenesis of chronic obstructive pulmonary disease following exposure to ambient particulate matter is largely unknown. We hypothesized that exposure alters gut microbial composition and metabolites and may involved in the pathogenesis of chronic obstructive pulmonary disease.Methods: Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel, or motor vehicle exhaust for 4, 12, and 24 weeks. Lung tissue was assessed histologically and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified. Results: After a 24-week exposure to particulate matter, rats exhibited pulmonary inflammation and pathological changes characteristic of chronic obstructive pulmonary disease. The gut microbiome was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide. Conclusion: Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.

scholarly journals Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

2020 ◽  
Author(s):  
Naijian Li ◽  
Zhaowei Yang ◽  
Baoling Liao ◽  
Tianhui Pan ◽  
Jinding Pu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Particulate Matter ◽  
Pulmonary Disease ◽  
Chronic Exposure ◽  
Short Chain Fatty Acids ◽  
Chronic Obstructive ◽  
Ambient Particulate Matter ◽  
Microbial Composition ◽  
Obstructive Pulmonary Disease ◽  
Microbial Dysbiosis

Abstract Background The role of the gut microbiota in the pathogenesis of chronic obstructive pulmonary disease following exposure to ambient particulate matter is largely unknown. We hypothesized that exposure alters gut microbial composition and metabolites and is involved in the pathogenesis of chronic obstructive pulmonary disease. Methods Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel, or motor vehicle exhaust for 4, 12, and 24 weeks. Lung tissue was assessed histologically and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified. Results After a 24-week exposure to particulate matter, rats exhibited pulmonary inflammation and pathological changes characteristic of chronic obstructive pulmonary disease. The gut microbiome was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide. Conclusion Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.

scholarly journals Role of Estrogen on Alveolar Macrophage Polarization in Response to Particulate Matter Exposure

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Nathalie Fuentes ◽  
Jonathan Pesantez ◽  
Marvin Nicoleau ◽  
Randy Vander Wal ◽  
Zissis Chroneos ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Alveolar Macrophage ◽  
Macrophage Polarization ◽  
Particulate Matter Exposure

AMBIENT PARTICULATE MATTER (PM10 AND PM2.5) AIR POLLUTION IN DESNIANSKY DISTRICT IN KYIV

2017 ◽  
Vol 2017 (67) ◽  
pp. 31-37
Author(s):  
O. Turos ◽  
◽  
T. Maremukha ◽  
I. Kobzarenko ◽  
A. Petrosian ◽  
...  
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Ambient Particulate Matter ◽  
Pm10 And Pm2.5
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