scholarly journals Effects of a short‐term cold exposure on circulating microRNAs and metabolic parameters in healthy adult subjects

2021 ◽  
Author(s):  
Marc Thibonnier ◽  
Sujoy Ghosh ◽  
Anne Blanchard
Keyword(s):  
Cold Exposure ◽  
Healthy Adult ◽  
Metabolic Parameters ◽  
Short Term ◽  
Circulating Micrornas

scholarly journals Circulating miR-375 Correlates With Response of Human Individuals to Short-Term Cold Exposure

2021 ◽  
Author(s):  
Claudine Seeliger ◽  
Laura Aline Mengel ◽  
Lise Buekens ◽  
Alberto Mesas-Fernández ◽  
Thomas Skurk ◽  
...  
Keyword(s):  
Cold Exposure ◽  
Significant Negative Correlation ◽  
Fat Tissue ◽  
Short Term ◽  
Circulating Micrornas ◽  
Expression Levels ◽  
Mirna Array ◽  
Before And After ◽  
Supraclavicular Skin Temperature ◽  
Shivering Thermogenesis

Abstract Cold-induced non-shivering thermogenesis (CIT) of the human body is currently discussed as an important contributor to energy metabolism, and miRNAs have recently been reported as key regulators of metabolism. Identifying the link of CIT and circulating microRNAs (miRNAs) in a large cohort of human individuals remains elusive to date. Here, we analyzed a set of 158 miRNAs in the serum of 97 female and 72 male healthy individuals before and after cold exposure (CE). Validating the results of a miRNA array, a significant down-regulation of miR-375 was measured in individuals after CIT (P<0.0001). These changes went along with a significant negative correlation between miR‑375 and the supraclavicular skin temperature (P=0.012). Additionally, the regulation of miR-375 was sex-dependent, with female individuals showing a significantly stronger decrease in expression of miR-375 under CIT compared to males. Such findings were already seen under thermoneutral conditions, where females display significant lower miR-375 expression levels (P=0.015). Besides, the lower miR‑375 expression levels were negatively correlated with the amount of visceral fat tissue in the female cohort (P=0.0002). This study identified miR-375 as a potential new sex-dependent marker for cold-induced thermogenesis.

Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study

2017 ◽  
Vol 31 (10) ◽  
pp. 1374-1376
Author(s):  
Jack H Wilson ◽  
Amy H Criss ◽  
Sean A Spangler ◽  
Katherine Walukevich ◽  
Sandra Hewett
Keyword(s):  
Young Adults ◽  
Healthy Adult ◽  
Adult Population ◽  
Critical Role ◽  
Random Order ◽  
Controlled Study ◽  
High Dose ◽  
Short Term ◽  
Double Blind ◽  
Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7–10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.

A Review of Metabolic Parameters in Quetiapine Studies Across Diagnoses

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J. Newcomer ◽  
R. Ratner ◽  
M. Åström ◽  
H. Eriksson
Keyword(s):  
Atypical Antipsychotics ◽  
Extended Release ◽  
Term Treatment ◽  
Metabolic Parameters ◽  
Short Term ◽  
Pooled Data ◽  
Long Term Treatment ◽  
Potential Risks ◽  
The Difference

Background:Data pertaining to changes in weight during long-term treatment with quetiapine (QTP) have been published previously (1).Methods:Pooled data are presented from 26 short-term clinical studies (up to 12 weeks) of QTP or quetiapine extended-release (QTP XR)-as monotherapy or adjunct therapy-conducted by AstraZeneca up to November 2007. Studies were conducted in adult patients (18-65 years) across a number of psychiatric diagnoses. Variables were analyzed irrespective of fasting status with similar analyses planned in the fasting subset. LSM changes from baseline for the difference between QTP and placebo are presented.Results:Approximately 10000 patients were included in the analyses, 70% of whom were treated with QTP or QTP XR. Across the entire short-term dataset, the difference in LSM change in weight for QTP vs. placebo was 1.07 kg. Corresponding differences in glucose regulation parameters were 1.39 mg/dL for glucose and 0.04% units for HbA1C. the overall difference in total cholesterol was 5.48 mg/dL, with differences in HDL and LDL cholesterol of -0.62 mg/dL and 1.69 mg/dL. the difference in LSM change in triglycerides was 22.62 mg/dL.Discussion:Within the context of balancing potential risks against the acknowledged benefits of atypical antipsychotics, the degree and significance of variations in metabolic parameters is an area of continued interest. This analysis helps clinicians to better understand changes in important metabolic parameters across trials with QTP and QTP XR, and the size and uniqueness of the dataset permits further analyses within this important area.Supported by funding from AstraZeneca Pharmaceuticals LP.

Uric acid and glutathione levels during short-term whole body cold exposure

1994 ◽  
Vol 16 (3) ◽  
pp. 299-305 ◽  
Author(s):  
Werner G. Siems ◽  
Frederik J.G.M. van Kuijk ◽  
Ralph Maass ◽  
Rainer Brenke
Keyword(s):  
Uric Acid ◽  
Cold Exposure ◽  
Whole Body ◽  
Short Term

Short-term cold exposure activates TRH neurons exclusively in the hypothalamic paraventricular nucleus and raphe pallidus

2012 ◽  
Vol 518 (2) ◽  
pp. 86-91 ◽  
Author(s):  
Agustina Cabral ◽  
Spring Valdivia ◽  
Mirta Reynaldo ◽  
Nicole E. Cyr ◽  
Eduardo A. Nillni ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Cold Exposure ◽  
Hypothalamic Paraventricular Nucleus ◽  
Short Term ◽  
Raphe Pallidus

Sprint Interval Training Decreases Circulating MicroRNAs Important for Muscle Development

2017 ◽  
Vol 39 (01) ◽  
pp. 67-72 ◽  
Author(s):  
Joshua Denham ◽  
Adrian Gray ◽  
John Scott-Hamilton ◽  
Amanda Hagstrom
Keyword(s):  
Muscle Development ◽  
Acute Exercise ◽  
Interval Training ◽  
Cycle Ergometer ◽  
Sprint Interval Training ◽  
Circulating Mirnas ◽  
Short Term ◽  
Circulating Micrornas ◽  
Exercise Interventions ◽  
Before And After

AbstractSmall non-coding RNAs, such as microRNAs (miRNAs), have emerged as powerful post-transcriptional regulators of gene expression that play important roles in many developmental and biological processes. In this study, we assessed the abundance of circulating microRNAs important for skeletal muscle and heart adaptations to exercise (miR-1, miR-133a, miR-133b and miR-486), following acute exercise and short-term sprint interval training (SIT). Twenty-eight individuals completed four all-out efforts on a cycle ergometer, and donated blood before and 30 min after the cessation of exercise. A subset of 10 untrained men completed 4-6 efforts of SIT, three times a week for 6 weeks, and donated resting blood samples before and after the intervention. MiRNA TaqMan qPCR was performed and whilst no changes were observed after a single session of SIT (all p>0.05), the 6-wk SIT intervention significantly reduced the whole blood content of all four miRNAs (mean fold-changes: 0.37–0.48, all p<0.01). Our data suggests that circulating miRNAs are responsive to short-term SIT and could have roles in SIT-induced health and performance adaptations. Further work is required to establish whether circulating miRNAs could serve as biomarkers for predicting exercise training responses and monitoring exercise interventions.

scholarly journals The metabolic responses to 24-h fasting and mild cold exposure in overweight individuals are correlated and accompanied by changes in FGF21 concentration

2020 ◽  
Author(s):  
Ada Admin ◽  
Tim Hollstein ◽  
Sascha Heinitz ◽  
Takafumi Ando ◽  
Theresa L. Rodzevik ◽  
...  
Keyword(s):  
Cold Exposure ◽  
Metabolic Phenotype ◽  
Metabolic Responses ◽  
Fibroblast Growth Factor 21 ◽  
Short Term ◽  
Physiological Mechanisms ◽  
Human Phenotype ◽  
Percentage Body Fat ◽  
Highly Correlated ◽  
The Individual

A greater decrease in 24-h energy expenditure (24EE) during 24h fasting defines a <i>thriftier</i> metabolic phenotype prone to weight gain during overfeeding and resistant to weight loss during caloric restriction. As the thermogenic response to mild cold exposure (COLD) may similarly characterize this human phenotype identified by acute fasting conditions, we analyzed changes in 24EE and sleeping metabolic rate (SLEEP) in a whole-room indirect calorimeter during 24h fasting at thermoneutrality (24°C) and during energy balance both at thermoneutrality (24°C) and mild cold (19°C) in 20 healthy volunteers (80% male, age: 36.6±11.4y, percentage body fat: 34.8±10.5%). Greater decrease in 24EE during fasting (<i>thriftier</i> phenotype) was associated with less increase in 24EE during COLD, i.e. less cold-induced thermogenesis. Greater decreases in plasma fibroblast growth factor 21 (FGF21) after 24h fasting and after COLD were highly correlated and associated with greater decreases in SLEEP in both conditions. We conclude that the metabolic responses to short-term fasting and COLD are associated and mediated by the liver-derived hormone FGF21. Thus, the 24EE response to COLD further identifies the <i>thrifty</i> versus <i>spendthrift</i> phenotype, providing an additional setting to investigate the physiological mechanisms underlying the human metabolic phenotype and characterizing the individual susceptibility to weight change.

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