scholarly journals MicroRNA‐150 and its target ETS‐domain transcription factor 1 contribute to inflammation in diabetic photoreceptors

2021 ◽  
Author(s):  
Fei Yu ◽  
Michael L. Ko ◽  
Gladys Y.‐P. Ko
Keyword(s):  
Transcription Factor ◽  
Ets Domain ◽  
Transcription Factor 1

scholarly journals ETS-Domain Transcription Factor Elk-1 Regulates Stemness Genes in Brain Tumors and CD133+ BrainTumor-Initiating Cells

2021 ◽  
Vol 11 (2) ◽  
pp. 125
Author(s):  
Melis Savasan Sogut ◽  
Chitra Venugopal ◽  
Basak Kandemir ◽  
Ugur Dag ◽  
Sujeivan Mahendram ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Brain Tumor ◽  
Brain Tumors ◽  
System Development ◽  
Nervous System Development ◽  
Stem Cell Population ◽  
Tumor Initiating Cells ◽  
Specific Domain ◽  
Brain Tumor Initiating Cells ◽  
Ets Domain

Elk-1, a member of the ternary complex factors (TCFs) within the ETS (E26 transformation-specific) domain superfamily, is a transcription factor implicated in neuroprotection, neurodegeneration, and brain tumor proliferation. Except for known targets, c-fos and egr-1, few targets of Elk-1 have been identified. Interestingly, SMN, SOD1, and PSEN1 promoters were shown to be regulated by Elk-1. On the other hand, Elk-1 was shown to regulate the CD133 gene, which is highly expressed in brain-tumor-initiating cells (BTICs) and used as a marker for separating this cancer stem cell population. In this study, we have carried out microarray analysis in SH-SY5Y cells overexpressing Elk-1-VP16, which has revealed a large number of genes significantly regulated by Elk-1 that function in nervous system development, embryonic development, pluripotency, apoptosis, survival, and proliferation. Among these, we have shown that genes related to pluripotency, such as Sox2, Nanog, and Oct4, were indeed regulated by Elk-1, and in the context of brain tumors, we further showed that Elk-1 overexpression in CD133+ BTIC population results in the upregulation of these genes. When Elk-1 expression is silenced, the expression of these stemness genes is decreased. We propose that Elk-1 is a transcription factor upstream of these genes, regulating the self-renewal of CD133+ BTICs.

scholarly journals E2F transcription factor-1 regulates oxidative metabolism

2011 ◽  
Vol 13 (9) ◽  
pp. 1146-1152 ◽  
Author(s):  
Emilie Blanchet ◽  
Jean-Sébastien Annicotte ◽  
Sylviane Lagarrigue ◽  
Victor Aguilar ◽  
Cyrielle Clapé ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Oxidative Metabolism ◽  
E2f Transcription Factor ◽  
Transcription Factor 1
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