scholarly journals Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial‐mesenchymal plasticity of human peritoneal mesothelial cells

2021 ◽  
Author(s):  
Lingling Gao ◽  
Xin Nie ◽  
Rui Gou ◽  
Yuexin Hu ◽  
Hui Dong ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Mesothelial Cells ◽  
Ovarian Cancer Cells ◽  
Peritoneal Mesothelial Cells ◽  
Human Peritoneal Mesothelial Cells

Human Peritoneal Mesothelial Cells Are More Potent Than Ovarian Cancer Cells in Producing Tumor Marker CA-125

1996 ◽  
Vol 62 (3) ◽  
pp. 384-389 ◽  
Author(s):  
Alain G. Zeimet ◽  
Christian Marth ◽  
Felix A. Offner ◽  
Peter Obrist ◽  
Michael Uhl-Steidl ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Marker ◽  
Cancer Cells ◽  
Mesothelial Cells ◽  
Ca 125 ◽  
Ovarian Cancer Cells ◽  
Peritoneal Mesothelial Cells ◽  
Human Peritoneal Mesothelial Cells

scholarly journals Amelioration of human peritoneal mesothelial cell co-culture-evoked malignant potential of ovarian cancer cells by acacetin involves LPA release-activated RAGE-PI3K/AKT signaling

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Meng Tian ◽  
Yingjie Tang ◽  
Ting Huang ◽  
Yang Liu ◽  
Yingzheng Pan
Keyword(s):  
Ovarian Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Inflammatory Cytokine ◽  
Mesothelial Cell ◽  
Akt Signaling ◽  
Mesothelial Cells ◽  
Ovarian Cancer Cells ◽  
Peritoneal Mesothelial Cells ◽  
Proliferation And Invasion

Abstract Background Ovarian cancer is a devastating gynecological malignancy and frequently presents as an advanced carcinoma with disseminated peritoneum metastasis. Acacetin exerts anti-cancerous effects in several carcinomas. Here, we sought to investigate acacetin function in ovarian cancer malignancy triggered by peritoneal mesothelial cells. Methods Peritoneal mesothelial cells were treated with acacetin, and then the conditioned medium was collected to treat ovarian cancer cells. Then, cell proliferation was analyzed by MTT assay. Transwell analysis was conducted to evaluate cell invasion. Protein expression was determined by western blotting. ELISA and qRT-PCR were applied to analyze inflammatory cytokine levels. The underlying mechanism was also explored. Results Acacetin suppressed cell proliferation and invasion, but enhanced cell apoptosis. Furthermore, mesothelial cell-evoked malignant characteristics were inhibited when mesothelial cells were pre-treated with acacetin via restraining cell proliferation and invasion, concomitant with decreases in proliferation-related PCNA, MMP-2 and MMP-9 levels. Simultaneously, acacetin reduced mesothelial cell-induced transcripts and production of pro-inflammatory cytokine IL-6 and IL-8 in ovarian cancer cells. Mechanically, acacetin decreased lysophosphatidic acid (LPA) release from mesothelial cells, and subsequent activation of receptor for advanced glycation end-products (RAGE)-PI3K/AKT signaling in ovarian cancer cells. Notably, exogenous LPA restored the above pathway, and offset the efficacy of acacetin against mesothelial cell-evoked malignancy in ovarian cancer cells, including cell proliferation, invasion and inflammatory cytokine production. Conclusions Acacetin may not only engender direct inhibition of ovarian cancer cell malignancy, but also antagonize mesothelial cell-evoked malignancy by blocking LPA release-activated RAGE-PI3K/AKT signaling. Thus, these findings provide supporting evidence for a promising therapeutic agent against ovarian cancer. Graphical Abstract

scholarly journals Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells

1999 ◽  
Vol 6 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Injae Chung ◽  
Peter E Schwartz ◽  
Ronald G Crystal ◽  
Giuseppe Pizzorno ◽  
John Leavitt ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Transgene Expression ◽  
Mesothelial Cells ◽  
Ovarian Cancer Cells

Expression of the miR200 Family of microRNAs in Mesothelial Cells Suppresses the Dissemination of Ovarian Cancer Cells

2014 ◽  
Vol 13 (8) ◽  
pp. 2081-2091 ◽  
Author(s):  
Kazuya Sugiyama ◽  
Hiroaki Kajiyama ◽  
Kiyosumi Shibata ◽  
Hong Yuan ◽  
Fumitaka Kikkawa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Mesothelial Cells ◽  
Ovarian Cancer Cells

HMOCC-1, a human monoclonal antibody that inhibits adhesion of ovarian cancer cells to human mesothelial cells

2004 ◽  
Vol 95 (2) ◽  
pp. 290-298 ◽  
Author(s):  
Nao Suzuki ◽  
Daisuke Aoki ◽  
Yutaka Tamada ◽  
Nobuyuki Susumu ◽  
Kimiko Orikawa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Monoclonal Antibody ◽  
Cancer Cells ◽  
Human Monoclonal Antibody ◽  
Mesothelial Cells ◽  
Ovarian Cancer Cells
Sign in / Sign up

Export Citation Format

Share Document