scholarly journals An imbalance in autophagy contributes to retinal damage in a rat model of oxygen‐induced retinopathy

2021 ◽  
Author(s):  
Noemi Anna Pesce ◽  
Alessio Canovai ◽  
Flavia Plastino ◽  
Emma Lardner ◽  
Anders Kvanta ◽  
...  
Keyword(s):  
Rat Model ◽  
Retinal Damage ◽  
Oxygen Induced Retinopathy

Retinal VEGF levels correlate with ocular circulation measured by a laser speckle-micro system in an oxygen-induced retinopathy rat model

2017 ◽  
Vol 255 (10) ◽  
pp. 1981-1990 ◽  
Author(s):  
Tadashi Matsumoto ◽  
Yuta Saito ◽  
Takashi Itokawa ◽  
Tomoaki Shiba ◽  
Mari S. Oba ◽  
...  
Keyword(s):  
Rat Model ◽  
Laser Speckle ◽  
Ocular Circulation ◽  
Oxygen Induced Retinopathy

Variable oxygen and retinal VEGF levels: correlation with incidence and severity of pathology in a rat model of oxygen-induced retinopathy

2004 ◽  
Vol 79 (5) ◽  
pp. 623-630 ◽  
Author(s):  
Xiang Q. Werdich ◽  
Gary W. McCollum ◽  
Veera S. Rajaratnam ◽  
John S. Penn
Keyword(s):  
Rat Model ◽  
Oxygen Induced Retinopathy

scholarly journals Orally Active Multi-Functional Antioxidants Are Neuroprotective in a Rat Model of Light-Induced Retinal Damage

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e21926 ◽  
Author(s):  
James Randazzo ◽  
Zifeng Zhang ◽  
Michael Hoff ◽  
Hiroyoshi Kawada ◽  
Andrew Sachs ◽  
...  
Keyword(s):  
Rat Model ◽  
Retinal Damage ◽  
Orally Active

scholarly journals Tyrosine-Protein Phosphatase Non-receptor Type 9 (PTPN9) Negatively Regulates the Paracrine Vasoprotective Activity of Bone-Marrow Derived Pro-angiogenic Cells: Impact on Vascular Degeneration in Oxygen-Induced Retinopathy

2021 ◽  
Vol 9 ◽  
Author(s):  
Michel Desjarlais ◽  
Pakiza Ruknudin ◽  
Maëlle Wirth ◽  
Isabelle Lahaie ◽  
Rabah Dabouz ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Rat Model ◽  
Protein Phosphatase ◽  
Ex Vivo ◽  
Stem Cell Differentiation ◽  
Negative Regulator ◽  
Receptor Type ◽  
Vegf Receptor ◽  
Tubule Formation ◽  
Oxygen Induced Retinopathy

Background and AimInsufficient post-ischemic neovascularization is an initial key step in the pathogenesis of Oxygen-Induced Retinopathy (OIR). During neovascularization, pro-angiogenic cells (PACs) are mobilized from the bone marrow and integrate into ischemic tissues to promote angiogenesis. However, the modulation of PAC paracrine activity during OIR and the specific mechanisms involved remain to be explored. Because Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) is reported to be a negative regulator of stem cell differentiation and angiogenesis signaling, we investigated its effect on PAC activity in the context of OIR.Methods and ResultsIn a rat model of OIR, higher levels of PTPN9 in the retina and in bone marrow derived PACs are associated with retinal avascular areas, lower levels of the mobilization factor SDF-1 and decreased number of CD34+/CD117+/CD133+ PACs. PACs exposed ex vivo to hyperoxia display increased PTPN9 expression, which is associated with impaired ability of PAC secretome to promote angiogenesis ex vivo (choroidal vascular sprouting) and in vitro (endothelial cell tubule formation) compared to the secretome of PACs maintained in normoxia. Suppression of PTPN9 (using siRNA) increases VEGF and SDF-1 expression to normalize PAC secretome during hyperoxia, leading to restored angiogenic ability of PAC secretome. Moreover, endothelial cells exposed to the secretome of siPTPN9-treated PACs expressed increased levels of activated form of VEGF receptor 2 (VEGFR2). In the rat model of OIR, intravitreal injection of secretome from siPTPN9-treated PACs significantly reduced retinal vaso-obliteration; this was associated with higher retinal levels of VEGF/SDF-1, and increased recruitment of PACs (CD34+ cells) to the retinal and choroidal vessels.ConclusionOur results suggest that hyperoxia alters the paracrine proangiogenic activity of BM-PACs by inducing PTPN9, which can contribute to impair post-ischemic revascularization in the context of OIR. Targeting PTPN9 restores PAC angiogenic properties, and provide a new target for vessel integrity in ischemic retinopathies.

scholarly journals Ocular Versus Oral Propranolol for Prevention and/or Treatment of Oxygen-Induced Retinopathy in a Rat Model

2021 ◽  
Author(s):  
Areej Qadri ◽  
Charles L. Cai ◽  
Karen Deslouches ◽  
Faisal Siddiqui ◽  
Jacob V. Aranda ◽  
...  
Keyword(s):  
Rat Model ◽  
Oxygen Induced Retinopathy ◽  
Oral Propranolol

Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes

2019 ◽  
Vol 56 (9) ◽  
pp. 1031-1036 ◽  
Author(s):  
Carmen Clapp ◽  
Nundehui Diaz-Lezama ◽  
Elva Adan-Castro ◽  
Gabriela Ramirez-Hernandez ◽  
Bibiana Moreno-Carranza ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Rat Model ◽  
P2x7 Receptor ◽  
Retinal Damage ◽  
Pharmacological Blockade

scholarly journals Gene Expression Changes in a Rat Model of Oxygen-Induced Retinopathy

2011 ◽  
Vol 25 (1) ◽  
pp. 42 ◽  
Author(s):  
Na Eun Lee ◽  
Yeon Jeong Park ◽  
In Young Chung ◽  
Seong Wook Seo ◽  
Jong Moon Park ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Model ◽  
Oxygen Induced Retinopathy

Pattern electroretinography in a rat model of ocular hypertension: functional evidence for early detection of inner retinal damage

2005 ◽  
Vol 81 (3) ◽  
pp. 340-349 ◽  
Author(s):  
Gil Ben-Shlomo ◽  
Sharon Bakalash ◽  
George N. Lambrou ◽  
Elisabeth Latour ◽  
William W. Dawson ◽  
...  
Keyword(s):  
Early Detection ◽  
Ocular Hypertension ◽  
Rat Model ◽  
Retinal Damage ◽  
Pattern Electroretinography
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