scholarly journals Axl‐inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model

2021 ◽  
Author(s):  
August Hoel ◽  
Tarig Osman ◽  
Fredrik Hoel ◽  
Hassan Elsaid ◽  
Tony Chen ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Murine Model ◽  
Ureter Obstruction

scholarly journals Esculetin Restores Mitochondrial Dysfunction and Reduces Allergic Asthma Features in Experimental Murine Model

2009 ◽  
Vol 183 (3) ◽  
pp. 2059-2067 ◽  
Author(s):  
Ulaganathan Mabalirajan ◽  
Amit Kumar Dinda ◽  
Surendra Kumar Sharma ◽  
Balaram Ghosh
Keyword(s):  
Mitochondrial Dysfunction ◽  
Allergic Asthma ◽  
Murine Model ◽  
Experimental Murine Model

scholarly journals Hepatic Mitochondrial Dysfunction and Immune Response in a Murine Model of Peanut Allergy

Nutrients ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 744 ◽  
Author(s):  
Giovanna Trinchese ◽  
Lorella Paparo ◽  
Rosita Aitoro ◽  
Carmela Fierro ◽  
Michela Varchetta ◽  
...  
Keyword(s):  
Immune Response ◽  
Mitochondrial Dysfunction ◽  
Murine Model ◽  
Peanut Allergy

scholarly journals Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model

2009 ◽  
Vol 107 (4) ◽  
pp. 1285-1292 ◽  
Author(s):  
Ulaganathan Mabalirajan ◽  
Jyotirmoi Aich ◽  
Geeta Devi Leishangthem ◽  
Surendra Kumar Sharma ◽  
Amit Kumar Dinda ◽  
...  
Keyword(s):  
Vitamin E ◽  
Cytochrome C ◽  
Mitochondrial Dysfunction ◽  
Cytochrome C Oxidase ◽  
Murine Model ◽  
Ultrastructural Changes ◽  
Mitochondrial Dysfunctions ◽  
The Third ◽  
Bronchial Epithelia ◽  
Experimental Allergic

We showed recently that IL-4 causes mitochondrial dysfunction in allergic asthma. IL-4 is also known to induce 12/15-lipoxygenase (12/15-LOX), a potent candidate molecule in asthma. Because vitamin E (Vit-E) reduces IL-4 and inhibits 12/15-LOX in vitro, here we tested the hypothesis that Vit-E may be effective in restoring key mitochondrial dysfunctions, thus alleviating asthma features in an experimental allergic murine model. Ovalbumin (OVA)-sensitized and challenged male BALB/c mice showed the characteristic features of asthma such as airway hyperresponsiveness (AHR), airway inflammation, and airway remodeling. In addition, these mice showed increase in the expression and metabolites of 12/15-LOX, reduction in the activity and expression of the third subunit of mitochondrial cytochrome- c oxidase, and increased cytochrome c in lung cytosol, which indicate that OVA sensitization and challenge causes mitochondrial dysfunction. Vit-E was administered orally to these mice, and 12/15-LOX expression, key mitochondrial functions, ultrastructural changes of mitochondria in bronchial epithelia, and asthmatic parameters were determined. Vit-E treatment reduced AHR, Th2 response including IL-4, IL-5, IL-13, and OVA-specific IgE, eotaxin, transforming growth factor-β1, airway inflammation, expression and metabolites of 12/15-LOX in lung cytosol, lipid peroxidation, and nitric oxide metabolites in the lung, restored the activity and expression of the third subunit of cytochrome- c oxidase in lung mitochondria and bronchial epithelia, respectively, reduced the appearance of cytochrome c in lung cytosol, and also restored mitochondrial ultrastructural changes of bronchial epithelia. In summary, these findings show that Vit-E reduces key mitochondrial dysfunctions and alleviates asthmatic features.

Development of Mitochondrial Dysfunction in a Murine Model of Burn Injury

2014 ◽  
Vol 76 ◽  
pp. S117-S118
Author(s):  
Bartosz Szczesny ◽  
Craig Porter ◽  
Attila Brunyanszki ◽  
Gabor Olah ◽  
Tracy Toliver-Kinsky ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Murine Model ◽  
Burn Injury

Nonhematopoietic erythropoietin-derived peptide: Study of the atheroprotective activity using a novel murine model of mitochondrial dysfunction

2020 ◽  
Vol 315 ◽  
pp. e110-e111
Author(s):  
M. Korokin ◽  
M.V. Pokrovsky ◽  
M. Kubekina ◽  
A. Deykin ◽  
L. Korokina ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Murine Model
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