scholarly journals Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells

2021 ◽  
Author(s):  
Geetha Nalairndran ◽  
Ivy Chung ◽  
Azad Hassan Abdul Razack ◽  
Felicia Fei‐Lei Chung ◽  
Ling‐Wei Hii ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Janus Kinase ◽  
Prostate Cancer Cells ◽  
Janus Kinase 1 ◽  
Docetaxel Sensitivity

Regulation of Docetaxel Sensitivity in Prostate Cancer Cells by hsa-miR-125a-3p via Modulation of Metastasis-Associated Protein 1 Signaling

Urology ◽  
2017 ◽  
Vol 105 ◽  
pp. 208.e11-208.e17 ◽  
Author(s):  
Jian-zhou Liu ◽  
Feng-yan Yin ◽  
Chang-you Yan ◽  
Hui Wang ◽  
Xiao-hui Luo
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Docetaxel Sensitivity

scholarly journals 974 FUNCTIONAL P53 DETERMINES DOCETAXEL SENSITIVITY IN PROSTATE CANCER CELLS

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Chengfei Liu ◽  
Yeizi Zhu ◽  
Wei Lou ◽  
Xubao Shi ◽  
Ralph deVere White ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Docetaxel Sensitivity

scholarly journals Functional p53 determines docetaxel sensitivity in prostate cancer cells

The Prostate ◽  
2012 ◽  
Vol 73 (4) ◽  
pp. 418-427 ◽  
Author(s):  
Chengfei Liu ◽  
Yezi Zhu ◽  
Wei Lou ◽  
Nagalakshmi Nadiminty ◽  
Xinbin Chen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Docetaxel Sensitivity

scholarly journals Propofol Reversed Hypoxia-Induced Docetaxel Resistance in Prostate Cancer Cells by Preventing Epithelial–Mesenchymal Transition by Inhibiting Hypoxia-Inducible Factor 1α

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Jiang Qian ◽  
Sheliang Shen ◽  
Wei Chen ◽  
Nianping Chen
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Cancer Cell ◽  
Epithelial Mesenchymal Transition ◽  
Hypoxia Inducible Factor ◽  
Prostate Cancer Cells ◽  
Vimentin Expression ◽  
Mesenchymal Transition ◽  
Docetaxel Resistance ◽  
Docetaxel Sensitivity

Prostate cancer is the second most frequently diagnosed cancer worldwide. Hypoxia-induced epithelial–mesenchymal transition (EMT), driven by hypoxia-inducible factor 1α (HIF-1α), is involved in cancer progression and metastasis. The present study was designed to explore the role of propofol in hypoxia-induced resistance of prostate cancer cells to docetaxel. We used the Cell Counting Kit-8 and 5-ethynyl-2′-deoxyuridine incorporation assay to measure cell viability and cell proliferation, respectively, in prostate cancer cell lines. Then, we detected HIF-1α, E-cadherin, and vimentin expression using western blotting. Propofol reversed the hypoxia-induced docetaxel resistance in the prostate cancer cell lines. Propofol not only decreased hypoxia-induced HIF-1α expression, but also reversed hypoxia-induced EMT by suppressing HIF-1α. Furthermore, small interfering RNA–mediated silencing of HIF-1α reversed the hypoxia-induced docetaxel resistance, although there was little change in docetaxel sensitivity between the hypoxia group and propofol group. The induction of hypoxia did not affect E-cadherin and vimentin expression, and under the siRNA knockdown conditions, the effects of propofol were obviated. These data support a role for propofol in regulating EMT in prostate cancer cells. Taken together, our findings demonstrate that propofol plays an important role in hypoxia-induced docetaxel sensitivity and EMT in prostate cancer cells and that it is a potential drug for overcoming drug resistance in prostate cancer cells via HIF-1α suppression.

scholarly journals Dual role of autophagy on docetaxel-sensitivity in prostate cancer cells

2018 ◽  
Vol 9 (9) ◽  
Author(s):  
Riccardo Cristofani ◽  
Marina Montagnani Marelli ◽  
Maria Elena Cicardi ◽  
Fabrizio Fontana ◽  
Monica Marzagalli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Dual Role ◽  
Prostate Cancer Cells ◽  
Docetaxel Sensitivity

279: Inhibition of Cyclooxygenase-2 Pathway Overcomes the Heat-Resistance in Prostate Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 93-93
Author(s):  
Makoto Sumitomo ◽  
Kenji Kuroda ◽  
Takako Asano ◽  
Akio Horiguchi ◽  
Keiichi Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Heat Resistance ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Prostate Cancer Cells
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