scholarly journals Immunoproteasome impairment via β5i/LMP7‐deletion leads to sustained pancreatic injury from experimental pancreatitis

2021 ◽  
Author(s):  
Laura L. Freitas Chama ◽  
Frédéric Ebstein ◽  
Birthe Wiesrecker ◽  
Preshit R. Wagh ◽  
Elke Hammer ◽  
...  
Keyword(s):  
Pancreatic Injury ◽  
Experimental Pancreatitis

Effects of Immunosuppressive and Immunostimulative Treatment on Pancreatic Injury and Mortality in Severe Acute Experimental Pancreatitis

Pancreas ◽  
2006 ◽  
Vol 33 (2) ◽  
pp. 174-183 ◽  
Author(s):  
Bettina M. Rau ◽  
Colin M. Kr??ger ◽  
Cornelia Hasel ◽  
Vilma Oliveira ◽  
Claudia Rubie ◽  
...  
Keyword(s):  
Pancreatic Injury ◽  
Experimental Pancreatitis ◽  
Acute Experimental Pancreatitis

Dose dependence of ectopic protease activation and pancreatic injury in hypercalcemia-induced experimental pancreatitis

1995 ◽  
Vol 108 (4) ◽  
pp. A376
Author(s):  
K. Mithöfer ◽  
T.W. Frick ◽  
C. Fernandez-del Castillo ◽  
K.B. Lewandrowski ◽  
D.W. Rattner ◽  
...  
Keyword(s):  
Pancreatic Injury ◽  
Dose Dependence ◽  
Experimental Pancreatitis ◽  
Protease Activation

Senstilization of thoracic sensony neurons in experimental pancreatitis

2001 ◽  
Vol 120 (5) ◽  
pp. A179-A179
Author(s):  
J WINSTON ◽  
M SHENOY ◽  
P PASRICHA
Keyword(s):  
Experimental Pancreatitis

Experimental Pancreatitis and Plasma Lipids

1958 ◽  
Vol 35 (5) ◽  
pp. 465-472 ◽  
Author(s):  
C. Wang ◽  
L. Strauss ◽  
D. Adlersberg
Keyword(s):  
Plasma Lipids ◽  
Experimental Pancreatitis

scholarly journals Successful combination strategy of preoperative placement of an endoscopic nasopancreatic drainage catheter and pancreas preservation surgery for pancreatic injury with major pancreatic duct disruption: a case report

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Kenji Kandori ◽  
Wataru Ishii ◽  
Ryoji Iizuka
Keyword(s):  
Pancreatic Duct ◽  
Pancreatic Resection ◽  
Pancreatic Injury ◽  
Combination Strategy ◽  
Pancreatic Body ◽  
First Case ◽  
Endoscopic Nasopancreatic Drainage ◽  
Pancreas Preservation ◽  
Nasopancreatic Drainage ◽  
Grade Iii

Abstract Background The guidelines recommend pancreatic resection for grade III and IV pancreatic injuries. On the other hand, organ preservation is an important issue. Herein, we present the first case of pancreatic injury with major pancreatic duct (MPD) disruption that was treated with the combination of preoperative placement of endoscopic nasopancreatic drainage (ENPD) catheter and pancreas preservation surgery after endoscopic pancreatic stenting (EPS) failure. Case presentation A 70-year-old female diagnosed with pancreatic injury was admitted to our hospital. She was hemodynamically stable. ERP revealed MPD disruption, and EPS failed. An ENPD catheter was placed preoperatively at the site of injury. During laparotomy, we identified a partial-thickness laceration in the pancreatic body. At the site of injury, the tip of the ENPD catheter was found; therefore, the patient was diagnosed with grade III pancreatic body injury with MPD disruption. The extent of crush was not severe, and we had no difficulty in identifying the distal MPD segment. We inserted the ENPD catheter into the distal MPD segment. The ruptured MPD and the laceration was sutured, then pancreatic resection was prevented. She was discharged on POD 56. Conclusion The treatment strategy incorporated ERP, placement of an ENPD catheter preoperatively, and a simple surgery in a hemodynamically stable patient with pancreatic injury allows the pancreas and spleen to be preserved.

scholarly journals Acute pancreatitis in a patient with COVID-19

2021 ◽  
Vol 14 (2) ◽  
pp. e239656
Author(s):  
Rawan A Rahman AlHarmi ◽  
Tahera Fateel ◽  
Jalila Sayed Adnan ◽  
Kamel AlAwadhi
Keyword(s):  
Acute Pancreatitis ◽  
Pulmonary Disease ◽  
Invasive Procedure ◽  
Pancreatic Injury ◽  
History Taking ◽  
Complicated Course ◽  
Operating Surgeon

COVID-19 mainly causes pulmonary disease. Involvement of gastrointestinal and hepatobiliary systems, among other systems, has been reported. We report a case of acute pancreatitis in a patient with resolving COVID-19 pneumonia. History taking and investigations excluded other causes of pancreatitis. This case demonstrates the possibility of pancreatic injury in patients with COVID-19, in line with previously reported similar cases. We believe that it is imperative to screen patients presenting with acute pancreatitis for SARS-CoV-2. It is also important to take into consideration that patients with a complicated course who require an invasive procedure such as drainage might pose a risk of transmission to the operating surgeon or interventionist.

Localized pancreatic NF-κB activation and inflammatory response in taurocholate-induced pancreatitis

2001 ◽  
Vol 280 (6) ◽  
pp. G1197-G1208 ◽  
Author(s):  
Eva Vaquero ◽  
Ilya Gukovsky ◽  
Vjekoslav Zaninovic ◽  
Anna S. Gukovskaya ◽  
Stephen J. Pandol
Keyword(s):  
Transcription Factor ◽  
Inflammatory Response ◽  
Pancreatic Head ◽  
Pancreatic Injury ◽  
Nuclear Factor Κb ◽  
Saline Infusion ◽  
Activator Protein 1 ◽  
Local Inflammatory Response ◽  
Monocyte Chemoattractant Protein 1 ◽  
Factor Α

Transcription factor nuclear factor-κB (NF-κB) is activated in cerulein pancreatitis and mediates cytokine expression. The role of transcription factor activation in other models of pancreatitis has not been established. Here we report upregulation of NF-κB and inflammatory molecules, and their correlation with local pancreatic injury, in a model of severe pancreatitis. Rats received intraductal infusion of taurocholate or saline, and the pancreatic head and tail were analyzed separately. NF-κB and activator protein-1 (AP-1) activation were assessed by gel shift assay, and mRNA expression of interleukin-6, tumor necrosis factor-α, KC, monocyte chemoattractant protein-1, and inducible nitric oxide synthase was assessed by semiquantitative RT-PCR. Morphological damage and trypsin activation were much greater in the pancreatic head than tail, in parallel with a stronger activation of NF-κB and cytokine mRNA. Saline infusion mildly affected these parameters. AP-1 was strongly activated in both pancreatic segments after either taurocholate or saline infusion. NF-κB inhibition with N-acetylcysteine ameliorated the local inflammatory response. Correlation between localized NF-κB activation, cytokine upregulation, and tissue damage suggests a key role for NF-κB in the development of the inflammatory response of acute pancreatitis.

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