scholarly journals Puerarin attenuates intracerebral hemorrhage‐induced early brain injury possibly by PI3K/Akt signal activation‐mediated suppression of NF‐κB pathway

2021 ◽  
Author(s):  
Jun Zeng ◽  
Shizhong Zheng ◽  
Yizhao Chen ◽  
Yaoming Qu ◽  
Jiayu Xie ◽  
...  
Keyword(s):  
Brain Injury ◽  
Intracerebral Hemorrhage ◽  
Early Brain Injury ◽  
Signal Activation

scholarly journals Caveolin-1 Deletion Reduces Early Brain Injury after Experimental Intracerebral Hemorrhage

2011 ◽  
Vol 178 (4) ◽  
pp. 1749-1761 ◽  
Author(s):  
Che-Feng Chang ◽  
Shu-Fen Chen ◽  
Tzong-Shyuan Lee ◽  
Hung-Fu Lee ◽  
Szu-Fu Chen ◽  
...  
Keyword(s):  
Brain Injury ◽  
Intracerebral Hemorrhage ◽  
Early Brain Injury ◽  
Caveolin 1

The role of complement in brain injury following intracerebral hemorrhage: A review

2021 ◽  
pp. 113654
Author(s):  
Katherine Holste ◽  
Fan Xia ◽  
Hugh J.L. Garton ◽  
Shu Wan ◽  
Ya Hua ◽  
...  
Keyword(s):  
Brain Injury ◽  
Intracerebral Hemorrhage

scholarly journals TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yan Zhou ◽  
Tao Tao ◽  
Guangjie Liu ◽  
Xuan Gao ◽  
Yongyue Gao ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Therapeutic Target ◽  
Cortical Neurons ◽  
Neuronal Apoptosis ◽  
Early Brain Injury ◽  
Neurological Deficits ◽  
Human Brain Tissue

AbstractNeuronal apoptosis has an important role in early brain injury (EBI) following subarachnoid hemorrhage (SAH). TRAF3 was reported as a promising therapeutic target for stroke management, which covered several neuronal apoptosis signaling cascades. Hence, the present study is aimed to determine whether downregulation of TRAF3 could be neuroprotective in SAH-induced EBI. An in vivo SAH model in mice was established by endovascular perforation. Meanwhile, primary cultured cortical neurons of mice treated with oxygen hemoglobin were applied to mimic SAH in vitro. Our results demonstrated that TRAF3 protein expression increased and expressed in neurons both in vivo and in vitro SAH models. TRAF3 siRNA reversed neuronal loss and improved neurological deficits in SAH mice, and reduced cell death in SAH primary neurons. Mechanistically, we found that TRAF3 directly binds to TAK1 and potentiates phosphorylation and activation of TAK1, which further enhances the activation of NF-κB and MAPKs pathways to induce neuronal apoptosis. Importantly, TRAF3 expression was elevated following SAH in human brain tissue and was mainly expressed in neurons. Taken together, our study demonstrates that TRAF3 is an upstream regulator of MAPKs and NF-κB pathways in SAH-induced EBI via its interaction with and activation of TAK1. Furthermore, the TRAF3 may serve as a novel therapeutic target in SAH-induced EBI.

Ginsenoside Rg2 Ameliorates Brain Injury After Intracerebral Hemorrhage in a Rat Model of Preeclampsia

2021 ◽  
Author(s):  
Liying Cai ◽  
Feifei Hu ◽  
Wenwen Fu ◽  
Xiaofeng Yu ◽  
Weijie Zhong ◽  
...  
Keyword(s):  
Brain Injury ◽  
Intracerebral Hemorrhage ◽  
Rat Model

Clarithromycin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage via Suppressing Periostin-Related Pathways in Mice

2021 ◽  
Author(s):  
Hideki Kanamaru ◽  
Fumihiro Kawakita ◽  
Hirofumi Nishikawa ◽  
Fumi Nakano ◽  
Reona Asada ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Brain Injury ◽  
Early Brain Injury
Sign in / Sign up

Export Citation Format

Share Document