scholarly journals Angiogenic regulatory influence of extracellular matrix deposited by resting state asthmatic and non‐asthmatic airway smooth muscle cells is similar

2021 ◽  
Author(s):  
Alen Faiz ◽  
Louise M. Harkness ◽  
Gavin Tjin ◽  
Victor Bernal ◽  
Peter Horvatovich ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Resting State ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells ◽  
Asthmatic Airway ◽  
Regulatory Influence

Extracellular Matrix Regulates Enhanced Eotaxin Expression in Asthmatic Airway Smooth Muscle Cells

2006 ◽  
Vol 174 (4) ◽  
pp. 379-385 ◽  
Author(s):  
Vivien Chan ◽  
Janette K. Burgess ◽  
Jonathan C. Ratoff ◽  
Brian J. O'Connor ◽  
Anne Greenough ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells ◽  
Asthmatic Airway

Extracellular acidification stimulates IL-6 production and Ca2+ mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells

2010 ◽  
Vol 299 (4) ◽  
pp. L567-L577 ◽  
Author(s):  
Isao Ichimonji ◽  
Hideaki Tomura ◽  
Chihiro Mogi ◽  
Koichi Sato ◽  
Haruka Aoki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells ◽  
Acidic Ph ◽  
Human Airway Smooth Muscle ◽  
Extracellular Acidification ◽  
Asthmatic Airway ◽  
Human Airway

The asthmatic airway has been shown to be an acidic environment that may be involved in the pathophysiological features of asthma. However, the mechanism by which an acidic pH modulates the cellular activities involved in the asthmatic airway remains elusive. Here, we characterized acidic pH-induced actions in human airway smooth muscle cells (ASMCs). Extracellular acidification stimulates the mRNA expression and protein production of IL-6, a proinflammatory cytokine, in association with the phosphorylation of extracellular signal-regulated kinase (ERK) and p38MAPK, reflecting the activation of the enzymes. Acidification-induced cytokine production was inhibited by inhibitors of ERK and p38MAPK. Acidification also increased intracellular Ca2+ concentration, which was accompanied by cell rounding, most likely reflecting contraction. In ASMCs, OGR1 is expressed at by far the highest levels among proton-sensing G protein-coupled receptors. The knockdown of OGR1 and Gq/11 protein with their specific small interfering RNAs and an inhibition of Gq/11 protein with YM-254890 attenuated the acidification-induced actions. We conclude that extracellular acidification stimulates IL-6 production and Ca2+ mobilization through proton-sensing OGR1 receptors/Gq/11 proteins in human ASMCs.

Rhinovirus-induced IL-33 expression in asthmatic airway smooth muscle cells is TLR3-dependent and involves activation of TAK1

2016 ◽  
Author(s):  
Jenny Calvén ◽  
Hamid Akbarshahi ◽  
Sangeetha Ramu ◽  
Charalambos Michaeloudes ◽  
Kian Fan Chung ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells ◽  
Asthmatic Airway
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