scholarly journals Exosomes from neuronal stem cells may protect the heart from ischaemia/reperfusion injury via JAK1/2 and gp130

2021 ◽  
Author(s):  
Miroslava Katsur ◽  
Zhenhe He ◽  
Vladimir Vinokur ◽  
Randolph Corteling ◽  
Derek M Yellon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Neuronal Stem Cells ◽  
Ischaemia Reperfusion

scholarly journals Protective effect of GDNF -engineered amniotic fluid-derived stem cells on the renal ischaemia reperfusion injury in vitro

2017 ◽  
Vol 51 (2) ◽  
pp. e12400 ◽  
Author(s):  
Jia Wang ◽  
Fengzhen Wang ◽  
Zhuojun Wang ◽  
Shulin Li ◽  
Lu Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amniotic Fluid ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Renal Ischaemia ◽  
Ischaemia Reperfusion

scholarly journals Stem Cells and Their Role in Renal Ischaemia Reperfusion Injury

2013 ◽  
Vol 37 (1) ◽  
pp. 16-29 ◽  
Author(s):  
Atul Bagul ◽  
Jodie H. Frost ◽  
Martin Drage
Keyword(s):  
Stem Cells ◽  
Reperfusion Injury ◽  
Ischaemia Reperfusion Injury ◽  
Renal Ischaemia ◽  
Ischaemia Reperfusion

Gene Silencing using siRNA for Preventing Liver Ischaemia-Reperfusion Injury

2018 ◽  
Vol 24 (23) ◽  
pp. 2692-2700 ◽  
Author(s):  
H. Susana Marinho ◽  
Paulo Marcelino ◽  
Helena Soares ◽  
Maria Luísa Corvo
Keyword(s):  
Gene Silencing ◽  
Reperfusion Injury ◽  
Therapeutic Potential ◽  
Major Complication ◽  
Ischaemia Reperfusion Injury ◽  
Small Interference Rna ◽  
Ischaemia Reperfusion ◽  
Promising Therapeutic Approach ◽  
Sirna Therapy

Background: Ischaemia-reperfusion injury (IRI), a major complication occurring during organ transplantation, involves an initial ischemia insult, due to loss of blood supply, followed by an inflammation-mediated reperfusion injury. A variety of molecular targets and pathways involved in liver IRI have been identified. Gene silencing through RNA interference (RNAi) by means of small interference RNA (siRNA) targeting mediators of IRI is a promising therapeutic approach. Objective: This study aims at reviewing the use of siRNAs as therapeutic agents to prevent IRI during liver transplantation. Method: We review the crucial choice of siRNA targets and the advantages and problems of the use of siRNAs. Results: We propose possible targets for siRNA therapy during liver IRI. Moreover, we discuss how drug delivery systems, namely liposomes, may improve siRNA therapy by increasing siRNA stability in vivo and avoiding siRNA off-target effects. Conclusion: siRNA therapeutic potential to preclude liver IRI can be improved by a better knowledge of what molecules to target and by using more efficient delivery strategies.

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