scholarly journals Construction of an immune‐related LncRNA signature with prognostic significance for bladder cancer

2021 ◽  
Author(s):  
Wen‐Jie Luo ◽  
Xi Tian ◽  
Wen‐Hao Xu ◽  
Yuan‐Yuan Qu ◽  
Wen‐Kai Zhu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Significance

Gene Signature of m 6A regulators in Bladder Cancer: Prognostic Significance and Immune Implication

2019 ◽  
Author(s):  
Yuying Zhang ◽  
Baoyi Zhu ◽  
Yi Cai ◽  
Minghui He ◽  
Chonghe Jiang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Significance ◽  
Gene Signature

Prognostic significance of altered p120ctnexpression in bladder cancer

2008 ◽  
Vol 101 (6) ◽  
pp. 746-752 ◽  
Author(s):  
Brasil Silva Neto ◽  
Gjanje L. Smith ◽  
Jessica A. Mandeville ◽  
Alex J. Vanni ◽  
Chad Wotkowicz ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Significance

Prognostic Significance of ABH Antigenicity of Mucosal Biopsies in Superficial Bladder Cancer

1986 ◽  
Vol 136 (6) ◽  
pp. 1194-1196 ◽  
Author(s):  
G. Das ◽  
N.J.C. Buxton ◽  
P.A. Hamilton Stewart ◽  
R.W. Glashan
Keyword(s):  
Bladder Cancer ◽  
Superficial Bladder Cancer ◽  
Prognostic Significance

scholarly journals Comprehensive Analysis of CPA4 as a Poor Prognostic Biomarker Correlated with Immune Cells Infiltration in Bladder Cancer

Biology ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1143
Author(s):  
Chengcheng Wei ◽  
Yuancheng Zhou ◽  
Qi Xiong ◽  
Ming Xiong ◽  
Yaxin Hou ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
T Cell ◽  
Immune Cells ◽  
Prognostic Significance ◽  
Gene Set Enrichment Analysis ◽  
Marker Genes ◽  
Gene Marker ◽  
Normal Tissues ◽  
Kaplan Meier ◽  
Diagnostic Potential

Carboxypeptidase A4 (CPA4) has shown the potential to be a biomarker in the early diagnosis of certain cancers. However, no previous research has linked CPA4 to therapeutic or prognostic significance in bladder cancer. Using data from The Cancer Genome Atlas (TCGA) database, we set out to determine the full extent of the link between CPA4 and BLCA. We further analyzed the interacting proteins of CPA4 and infiltrated immune cells via the TIMER2, STRING, and GEPIA2 databases. The expression of CPA4 in tumor and normal tissues was compared using the TCGA + GETx database. The connection between CPA4 expression and clinicopathologic characteristics and overall survival (OS) was investigated using multivariate methods and Kaplan–Meier survival curves. The potential functions and pathways were investigated via gene set enrichment analysis. Furthermore, we analyze the associations between CPA4 expression and infiltrated immune cells with their respective gene marker sets using the ssGSEA, TIMER2, and GEPIA2 databases. Compared with matching normal tissues, human CPA4 was found to be substantially expressed. We confirmed that the overexpression of CPA4 is linked with shorter OS, DSF(Disease-specific survival), PFI(Progression-free interval), and increased diagnostic potential using Kaplan–Meier and ROC analysis. The expression of CPA4 is related to T-bet, IL12RB2, CTLA4, and LAG3, among which T-bet and IL12RB2 are Th1 marker genes while CTLA4 and LAG3 are related to T cell exhaustion, which may be used to guide the application of checkpoint blockade and the adoption of T cell transfer therapy.

scholarly journals Correlation of APE1 with VEGFA and CD163+ macrophage infiltration in bladder cancer and their prognostic significance

2020 ◽  
Vol 20 (3) ◽  
pp. 2881-2887
Author(s):  
Lin-Ang Wang ◽  
Bo Yang ◽  
Tang Tang ◽  
Yuxin Yang ◽  
Dianzheng Zhang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Significance ◽  
Macrophage Infiltration

Sub-staging specific differences in recurrence-free, progression-free and cancer-specific survival for patients with T1 bladder cancer: a systematic review and meta-analysis

2020 ◽  
Author(s):  
GuanQiu Chen ◽  
Tao Yang ◽  
Pu Zhang ◽  
Meng-Zhao Zhang ◽  
Bo Yang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Significance ◽  
Treatment Strategies ◽  
Progression Free Survival ◽  
Staging System ◽  
Cochrane Library ◽  
Significant Prognostic Factor ◽  
Cancer Specific Survival ◽  
Free Survival ◽  
Significant Difference

Abstract Background: The efficiency of the T1 sub-staging system on categorizing bladder cancer (BC) patients into subgroups with different clinical outcomes was unclear. We summarized relevant evidences, including recurrence-free survival (RFS), progression-free survival (PFS) and cancer-specific survival (CSS), to analyze the prognostic significance of T1 sub-stage.Methods: Systematic literature searches of MEDLINE, EMBASE and the Cochrane Library were performed. We pooled data on recurrence, progression, and CSS from 35 studies.Results: The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) indicated the difference in RFS between T1a sub-stage and T1b sub-stage (HR1.28, 95%CI 1.14-1.43). The significant difference was observed in PFS between the two arms (HR 2.18, 95%CI 1.95-2.44). Worse CSS was found in T1b patients than T1a patients (HR 1.45, 95%CI 1.28-1.64).Conclusions: T1 sub-staging system based on the invasion depth into muscularis mucosae (MM) can be a significant prognostic factor for RFS, PFS, and CSS of patients with T1-BC. Urologists and pathologists are encouraged to work together to give a precise sub-stage classification of T1-BC, and T1 sub-staging system should be a routine part of any histopathological report when possible. Different treatment strategies need to be developed for both T1a-BC and T1b-BC.

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