scholarly journals Cell cytoskeleton and proliferation study for the RANKL‐induced RAW264.7 differentiation

2021 ◽  
Author(s):  
Lingbo Kong ◽  
Rui Ma ◽  
Yang Cao ◽  
Wanli Smith ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Cell Cytoskeleton

Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis

Surgery ◽  
1998 ◽  
Vol 124 (2) ◽  
pp. 362-371 ◽  
Author(s):  
Susan L. DeMeester ◽  
J.Perren Cobb ◽  
Richard S. Hotchkiss ◽  
Dale F. Osborne ◽  
Irene E. Karl ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Cytoskeleton

scholarly journals Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton

FEBS Journal ◽  
2008 ◽  
Vol 275 (19) ◽  
pp. 4675-4683 ◽  
Author(s):  
Xing-Zhen Chen ◽  
Qiang Li ◽  
Yuliang Wu ◽  
Genqing Liang ◽  
Carlos J. Lara ◽  
...  
Keyword(s):  
Microtubule Cytoskeleton ◽  
Cell Cytoskeleton

scholarly journals The Effect of Antioxidants on Photoreactivity and Phototoxic Potential of RPE Melanolipofuscin Granules from Human Donors of Different Age

Antioxidants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1044
Author(s):  
Magdalena M. Olchawa ◽  
Grzegorz M. Szewczyk ◽  
Andrzej C. Zadlo ◽  
Michal W. Sarna ◽  
Dawid Wnuk ◽  
...  
Keyword(s):  
Phagocytic Activity ◽  
Near Infrared ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Natural Antioxidants ◽  
Cellular Proteins ◽  
Paramagnetic Resonance ◽  
Time Resolved ◽  
Cell Cytoskeleton ◽  
Age Related

One of the most prominent age-related changes of retinal pigment epithelium (RPE) is the accumulation of melanolipofuscin granules, which could contribute to oxidative stress in the retina. The purpose of this study was to determine the ability of melanolipofuscin granules from younger and older donors to photogenerate reactive oxygen species, and to examine if natural antioxidants could modify the phototoxic potential of this age pigment. Electron paramagnetic resonance (EPR) oximetry, EPR-spin trapping, and time-resolved detection of near-infrared phosphorescence were employed for measuring photogeneration of superoxide anion and singlet oxygen by melanolipofuscin isolated from younger and older human donors. Phototoxicity mediated by internalized melanolipofuscin granules with and without supplementation with zeaxanthin and α-tocopherol was analyzed in ARPE-19 cells by determining cell survival, oxidation of cellular proteins, organization of the cell cytoskeleton, and the cell specific phagocytic activity. Supplementation with antioxidants reduced aerobic photoreactivity and phototoxicity of melanolipofuscin granules. The effect was particularly noticeable for melanolipofuscin mediated inhibition of the cell phagocytic activity. Antioxidants decreased the extent of melanolipofuscin-dependent oxidation of cellular proteins and disruption of the cell cytoskeleton. Although melanolipofuscin might be involved in chronic phototoxicity of the aging RPE, natural antioxidants could partially ameliorate these harmful effects.

Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton

2004 ◽  
Vol 78 (1) ◽  
pp. 109-123 ◽  
Author(s):  
Aileen Sandilands ◽  
Xin Wang ◽  
Aileen M Hutcheson ◽  
John James ◽  
Alan R Prescott ◽  
...  
Keyword(s):  
Fibre Cell ◽  
Cell Cytoskeleton ◽  
Lens Fibre ◽  
Lens Fibre Cell
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