scholarly journals Targeted dual inhibition of c‐Met/VEGFR2 signalling by foretinib improves antitumour effects of nanoparticle paclitaxel in gastric cancer models

2021 ◽  
Author(s):  
Meghan Grojean ◽  
Margaret A. Schwarz ◽  
Johann R. Schwarz ◽  
Sazzad Hassan ◽  
Urs von Holzen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Models ◽  
Dual Inhibition ◽  
Antitumour Effects

scholarly journals Development of a Novel Orthotopic Gastric Cancer Mouse Model

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Wonyoung Kang ◽  
Leigh Maher ◽  
Michael Michaud ◽  
Seong-Woo Bae ◽  
Seongyeong Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mouse Models ◽  
Cancer Metastasis ◽  
Soft Tissues ◽  
Tumor Formation ◽  
Cancer Model ◽  
Orthotopic Model ◽  
Cancer Models ◽  
Organotropic Metastasis ◽  
Nsg Mouse

Abstract Background Gastric cancer metastasis is a highly fatal disease with a five-year survival rate of less than 5%. One major obstacle in studying gastric cancer metastasis is the lack of faithful models available. The cancer xenograft mouse models are widely used to elucidate the mechanisms of cancer development and progression. Current procedures for creating cancer xenografts include both heterotopic (i.e., subcutaneous) and orthotopic transplantation methods. Compared to the heterotopic model, the orthotopic model has been shown to be the more clinically relevant design as it enables the development of cancer metastasis. Although there are several methods in use to develop the orthotopic gastric cancer model, there is not a model which uses various types of tumor materials, such as soft tissues, semi-liquid tissues, or culture derivatives, due to the technical challenges. Thus, developing the applicable orthotopic model which can utilize various tumor materials is essential. Results To overcome the known limitations of the current orthotopic gastric cancer models, such as exposure of tumor fragments to the neighboring organs or only using firm tissues for the orthotopic implantation, we have developed a new method allowing for the complete insertion of soft tissue fragments or homogeneously minced tissues into the stomach submucosa layer of the immunodeficient NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mouse. With this completely-closed transplantation method, tumors with various types of tissue may be used to establish orthotopic gastric cancer models without the risks of exposure to nearby organs or cell leakage. This surgical procedure was highly reproducible in generating forty-eight mouse models with a surgery success rate of 96% and tumor formation of 93%. Among four orthotopic patient-derived xenograft (PDX) models that we generated in this study, we verified that the occurrence of organotropic metastasis in either the liver or peritoneal cavity was the same as that of the donor patients. Conclusion Here we describe a new protocol, step by step, for the establishment of orthotopic xenograft of gastric cancer. This novel technique will be able to increase the use of orthotopic models in broader applications for not only gastric cancer research but also any research related to the stomach microenvironment.

scholarly journals The antitumour activity of 2‐(4‐amino‐3‐methylphenyl)‐5‐fluorobenzothiazole in human gastric cancer models is mediated by AhR signalling

2019 ◽  
Vol 24 (2) ◽  
pp. 1750-1759
Author(s):  
Yuling Wang ◽  
Ying Liu ◽  
Tao Tang ◽  
Ying Luo ◽  
Malcolm F. G. Stevens ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Antitumour Activity ◽  
Human Gastric Cancer ◽  
Cancer Models

Abstract B178: Targeting Myc in triple-negative breast cancer models through the dual inhibition of PIM kinases and CDK9

2018 ◽  
Author(s):  
Hillary Haws ◽  
Wontak Kim ◽  
Adam Siddiqui-Jain ◽  
David J. Bearss ◽  
Steven L. Warner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Pim Kinases ◽  
Cancer Models ◽  
Dual Inhibition

Abstract 2208: Targeted inhibition of FGF/PDGF/VEGF signaling enhances nanoparticle taxane response in preclinical gastric cancer models

2019 ◽  
Author(s):  
Niranjan Awasthi ◽  
Kate Crawford ◽  
Erin Bontrager ◽  
Sazzad Hassan ◽  
Urs von Holzen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Vegf Signaling ◽  
Cancer Models ◽  
Targeted Inhibition

Abstract 2208: Targeted inhibition of FGF/PDGF/VEGF signaling enhances nanoparticle taxane response in preclinical gastric cancer models

2019 ◽  
Author(s):  
Niranjan Awasthi ◽  
Kate Crawford ◽  
Erin Bontrager ◽  
Sazzad Hassan ◽  
Urs von Holzen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Vegf Signaling ◽  
Cancer Models ◽  
Targeted Inhibition

scholarly journals Therapeutic Effects of Anti-CD115 Monoclonal Antibody in Mouse Cancer Models through Dual Inhibition of Tumor-Associated Macrophages and Osteoclasts

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e73310 ◽  
Author(s):  
Laetitia Fend ◽  
Nathalie Accart ◽  
Jacqueline Kintz ◽  
Sandrine Cochin ◽  
Carine Reymann ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Therapeutic Effects ◽  
Tumor Associated Macrophages ◽  
Cancer Models ◽  
Dual Inhibition ◽  
Mouse Cancer Models

scholarly journals Biomarkers for antitumor activity of bevacizumab in gastric cancer models

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Yoriko Yamashita-Kashima ◽  
Kaori Fujimoto-Ouchi ◽  
Keigo Yorozu ◽  
Mitsue Kurasawa ◽  
Mieko Yanagisawa ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Antitumor Activity ◽  
Cancer Models
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