scholarly journals KYNU , a novel potential target that underpins CD44‐promoted breast tumour cell invasion

2021 ◽  
Author(s):  
Maryam Al‐Mansoob ◽  
Ishita Gupta ◽  
Radoslaw Stefan Rusyniak ◽  
Allal Ouhtit
Keyword(s):  
Cell Invasion ◽  
Tumour Cell ◽  
Breast Tumour ◽  
Breast Tumour Cell ◽  
Potential Target ◽  
Tumour Cell Invasion

scholarly journals Novel role of BRCA1 interacting C‐terminal helicase 1 ( BRIP1) in breast tumour cell invasion

2020 ◽  
Vol 24 (19) ◽  
pp. 11477-11488
Author(s):  
Balsam Rizeq ◽  
Saïd Sif ◽  
Gheyath K. Nasrallah ◽  
Allal Ouhtit
Keyword(s):  
Cell Invasion ◽  
Tumour Cell ◽  
Breast Tumour ◽  
Breast Tumour Cell ◽  
Tumour Cell Invasion

Breast tumour cell subpopulations with expression of the MYC and OCT4 proteins

2020 ◽  
Vol 51 (6) ◽  
pp. 717-728
Author(s):  
N. V. Litviakov ◽  
V. A. Bychkov ◽  
M. N. Stakheeva ◽  
M. K. Ibragimova ◽  
M. M. Tsyganov ◽  
...  
Keyword(s):  
Tumour Cell ◽  
Breast Tumour ◽  
Breast Tumour Cell ◽  
Cell Subpopulations

scholarly journals Cleavage of Extracellular Matrix Molecules: a role for ADAM8 in tumour cell invasion

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Taheera Ferdous ◽  
Panagiota Golfi ◽  
Uwe Schlomann ◽  
Marc D Zack ◽  
Joerg W Bartsch
Keyword(s):  
Extracellular Matrix ◽  
Cell Invasion ◽  
Tumour Cell ◽  
Extracellular Matrix Molecules ◽  
Tumour Cell Invasion

scholarly journals CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2963
Author(s):  
Jason C. Fleming ◽  
Jeongmin Woo ◽  
Karwan Moutasim ◽  
Christopher J. Hanley ◽  
Steven J. Frampton ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cell Invasion ◽  
Tumour Cell ◽  
3D Culture ◽  
Response To Therapy ◽  
Antibody Array ◽  
Hpv Status ◽  
Tumour Cell Invasion

Head and neck squamous cell carcinoma (HNSCC) is a heterogenous disease treated with surgery and/or (chemo) radiotherapy, but up to 50% of patients with late-stage disease develop locoregional recurrence. Determining the mechanisms underpinning treatment resistance could identify new therapeutic targets and aid treatment selection. C-terminal tensin-like (CTEN) is a member of the tensin family, upregulated in several cancers, although its expression and function in HNSCC are unknown. We found that CTEN is commonly upregulated in HNSCC, particularly HPV−ve tumours. In vitro CTEN was upregulated in HPV−ve (n = 5) and HPV+ve (n = 2) HNSCC cell lines. Stable shRNA knockdown of CTEN in vivo significantly reduced tumour growth (SCC-25), and functional analyses in vitro showed that CTEN promoted tumour cell invasion, colony formation and growth in 3D-culture (SCC-25, Detroit 562). RNA sequencing of SCC-25 cells following CTEN siRNA knockdown identified 349 differentially expressed genes (logFC > 1, p < 0.05). Gene ontology analysis highlighted terms relating to cell locomotion and apoptosis, consistent with in vitro findings. A membrane-based antibody array confirmed that CTEN regulated multiple apoptosis-associated proteins, including HSP60 and cleaved caspase-3. Notably, in a mixed cohort of HPV+ve and HPV−ve HNSCC patients (n = 259), we found a significant, independent negative association of CTEN with prognosis, limited to those patients treated with (chemo)radiotherapy, not surgery, irrespective of human papillomavirus (HPV) status. These data show that CTEN is commonly upregulated in HNSCC and exerts several functional effects. Its potential role in modulating apoptotic response to therapy suggests utility as a predictive biomarker or radio-sensitising target.

scholarly journals The differential processing of proenkephalin A in mouse and human breast tumour cell lines

1999 ◽  
Vol 161 (3) ◽  
pp. 475-484 ◽  
Author(s):  
BK Brar ◽  
PJ Lowry
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Tumour Cell ◽  
Breast Tumour ◽  
Human Breast ◽  
Human Breast Tumour ◽  
Breast Tumour Cell ◽  
Cell Lysates ◽  
Human Breast Tumour Cell ◽  
Tumour Cell Lines

We have carried out an investigation into the processing of the enkephalin-like immunoreactivity reported in breast tissue using two human breast tumour cell lines and a mouse tumour cell line. A 46 kDa form of proenkephalin (PE) has been observed in the cell lysates of two human breast tumour cell lines (MCF-7, ZR-75-1) and the mouse androgen-responsive Shionogi breast carcinoma cell line (SC115). PE processing in the cell lysates of these cells was assessed by a specific met-enkephalin RIA. The basal levels of processed PE in the MCF-7, ZR-75-1 and SC115 cell lysates were 30, 30 and 76% respectively. The processing enzymes PC1 and PC2, which have been implicated in the differential processing of PE, were detected by immunoblot analysis in these cells. PC1 was found within the cell extracts of all three cell lines. PC2 was only observed in the SC115 cell line, which may account for the higher percentage of processed PE measured. The cDNA of PC2 has been transfected into ZR-75-1 cells and this was accompanied by an increase in the level of processed PE from 30 to 76%. These breast tumour cell lines may provide a useful insight into the function of enkephalin-containing peptides in breast cancer.

A New In-Vitro Model to Study Tumour Cell Invasion

Metastasis ◽  
1980 ◽  
pp. 28-32 ◽  
Author(s):  
R. Tchao ◽  
A. B. Schleich ◽  
M. Frick ◽  
A. Mayer
Keyword(s):  
Cell Invasion ◽  
Tumour Cell ◽  
In Vitro Model ◽  
Tumour Cell Invasion ◽  
Vitro Model

scholarly journals Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion

2002 ◽  
Vol 86 (8) ◽  
pp. 1310-1315 ◽  
Author(s):  
A Siegert ◽  
C Rosenberg ◽  
W D Schmitt ◽  
C Denkert ◽  
S Hauptmann
Keyword(s):  
Nitric Oxide ◽  
Cell Lines ◽  
Cell Invasion ◽  
Tumour Cell ◽  
Colorectal Adenocarcinoma ◽  
Adenocarcinoma Cell ◽  
Tumour Cell Invasion
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