scholarly journals Cellular senescence, a novel therapeutic target for mesenchymal stem cells in acute kidney injury

2020 ◽  
Author(s):  
Lingfei Zhao ◽  
Chenxia Hu ◽  
Fei Han ◽  
Dajin Chen ◽  
Yanhong Ma ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Kidney Injury ◽  
Mesenchymal Stem Cells ◽  
Cellular Senescence ◽  
Therapeutic Target ◽  
Kidney Injury ◽  
Novel Therapeutic

scholarly journals Comparative study of allogenic and xenogeneic mesenchymal stem cells on cisplatin-induced acute kidney injury in Sprague-Dawley rats

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Rehab H. Ashour ◽  
Mohamed-Ahdy Saad ◽  
Mohamed-Ahmed Sobh ◽  
Fatma Al-Husseiny ◽  
Mohamed Abouelkheir ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Kidney Injury ◽  
Mesenchymal Stem Cells ◽  
Comparative Study ◽  
Kidney Injury ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Extracellular vesicles derived from mesenchymal stem cells as a potential therapeutic agent in acute kidney injury (AKI) in felines: review and perspectives

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Magdalena M. Kraińska ◽  
Natalia Pietrzkowska ◽  
Eliza Turlej ◽  
Li Zongjin ◽  
Krzysztof Marycz
Keyword(s):  
Stem Cells ◽  
Acute Kidney Injury ◽  
Mesenchymal Stem Cells ◽  
Extracellular Vesicles ◽  
Kidney Injury ◽  
Cargo Transport ◽  
Potential Benefits ◽  
Apoptotic Effects ◽  
Different Sources ◽  
Modern Tool

AbstractMesenchymal stem cells (MSCs), known from their key role in the regeneration process of tissues, and their abilities to release bioactive factors like extracellular vesicles (EVs) could be considered as a potential, modern tool in the treatment of AKI (acute kidney injury) in both human and veterinary patients. The complex pathophysiology of a renal function disorder (AKI) makes difficult to find a universal therapy, but the treatment strategy is based on MSCs and derived from them, EVs seem to solve this problem. Due to their small size, the ability of the cargo transport, the ease of crossing the barriers and the lack of the ability to proliferate and differentiate, EVs seem to have a significant impact on the development such therapy. Their additional impact associated with their ability to modulate immune response and inflammation process, their strong anti-fibrotic and anti-apoptotic effects and the relation with the releasing of the reactive oxygen species (ROS), that pivotal role in the AKI development is undoubtedly, limits the progress of AKI. Moreover, the availability of EVs from different sources encourages to extend research with using EVs from MSCs in AKI treatment in felines; in that, the possibilities of kidney injuries treatment are still limited to the classical therapies burdened with dangerous side effects. In this review, we underline the significance of the processes, in whose EVs are included during the AKI in order to show the potential benefits of EVs-MSCs-based therapies against AKI in felines.

scholarly journals FP205RENOPROTECTIVE EFFECTS OF TONSIL-DERIVED MESENCHYMAL STEM CELLS IN GENTAMICIN-INDUCED ACUTE KIDNEY INJURY

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii135-iii135
Author(s):  
Hyun-Soo Shin ◽  
Eun-Sun Ryu ◽  
Hak-Sun Choi ◽  
JiYeon Ko ◽  
Duk-Hee Kang
Keyword(s):  
Stem Cells ◽  
Acute Kidney Injury ◽  
Mesenchymal Stem Cells ◽  
Kidney Injury

scholarly journals Microparticles from Kidney-Derived Mesenchymal Stem Cells Act as Carriers of Proangiogenic Signals and Contribute to Recovery from Acute Kidney Injury

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e87853 ◽  
Author(s):  
Hoon Young Choi ◽  
Sung Jin Moon ◽  
Brian B. Ratliff ◽  
Sun Hee Ahn ◽  
Ara Jung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Kidney Injury ◽  
Mesenchymal Stem Cells ◽  
Kidney Injury

Use of Mesenchymal Stem Cells and Darbepoetin Improve Ischemia-Induced Acute Kidney Injury Outcomes

2012 ◽  
Vol 35 (6) ◽  
pp. 531-539 ◽  
Author(s):  
Bulent Altun ◽  
Rahmi Yilmaz ◽  
Tuncay Aki ◽  
Hadim Akoglu ◽  
Dilara Zeybek ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Kidney Injury ◽  
Mesenchymal Stem Cells ◽  
Kidney Injury ◽  
Injury Outcomes
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